Contraindications[edit]
Known contraindications include the following:[36]
Treatment with monoamine oxidase inhibitors (MAOIs) 14 days or less prior to treatment with tianeptine. Due to the potential for cardiovascular effects (including hypertension and cardiovascular collapse), convulsions, hyperthermia (high body temperature) and death.
Hypersensitivity to tianeptine or any of the tablet's excipients.
Being under the age of 15 years.
In vitro tianeptine and its two principal metabolites have no effects on monoamine uptake, release or neurotransmitter receptor binding.