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Opioids Tianeptine, is it any good?

Have to agree with everyone else.

This is a 'harm reduction' site after all.

If people are gonna use drugs, they shouldn't be reckless with it. That sounds more like self destruction rather than somebody who's just trying to get high & have a good time. I don't think people are being "judgemental" by pointing out the dangers of such behaviors.

You have no idea if what you even got was actually tianeptine, so taking that much for your first time is just crazy.

Please be careful.

My experience with tianeptine sulfate was incredibly boring & unremarkable. So glad you at least had a good time from it.
 
When I first got Tianeptine powder,I tried to eyeball a dose. I had that intense euphoria, but I was horribly "opioid sick". Spins, sweats, had to take to the bed, strongly opioid sick. It lasted all day and the next day I felt real bad, tired, washed out, like it really did a number on my body. Opioid sick has never been so bad as to give significant next day effects for me.

I have zero opioid tolerance, so there's that.

However, I was trying to eyeball 100mg. So, we're talking a little pile of Tianeptine. Goodness, a teaspoon would have to be 10-20 times that (or more). When I first read about him doing that much, I thought we'd hear about a hospital trip eventually.
 
brokedownpalace10 said:
When I first got Tianeptine powder,I tried to eyeball a dose. I had that intense euphoria, but I was horribly "opioid sick". Spins, sweats, had to take to the bed, strongly opioid sick. It lasted all day and the next day I felt real bad, tired, washed out, like it really did a number on my body. Opioid sick has never been so bad as to give significant next day effects for me.

I have zero opioid tolerance, so there's that.

However, I was trying to eyeball 100mg. So, we're talking a little pile of Tianeptine. Goodness, a teaspoon would have to be 10-20 times that (or more). When I first read about him doing that much, I thought we'd hear about a hospital trip eventually.
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The packaging recommends 3 heaping microspoons (came with the package), I just used a teaspoon instead, fairly sure it's either heavily diluted or the sulfate version is much less potent
 
chris_p said:
The packaging recommends 3 heaping microspoons (came with the package), I just used a teaspoon instead, fairly sure it's either heavily diluted or the sulfate version is much less potent
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What was that? 10 times the recommended dose (or more)?
Anyway, I fucked up. I found that 60mg was plenty for a person with no tolerance and I learned that, if you are in doses around that you have to have a scale accurate to .01mg. Live and learn.

(I used a scale accurate to .1mg. Weighed out a gram. And divided it into 10 piles. Not good enough.)
 
I don't actually recommend anyone do the kind of things I do, see it more as a documentation of the decisions I make and the consqeuences thereof

Thanks for the thread guys I took a deep read of all of it, my behaviour is definitely a bit of that of reckness naivity.. I've never once measured or tested a drug in my life have suffered some consequences because of it (3 hospitalizations, 3 day detainment in psych ward, 2 arrests) I came into bluelight thinking it would be a group of similar minded people and I have never really been into 'harm reduction' or any of that kind of thing my childhood also involved a lot of drug use including methamphetamine and mdma from age 14, most of the people here seems to be those of the older kind who have already gone through the same kind of thing, makes sense since Bluelight is an old ass forum, shouldn't have really expected anything besides deserved criticism
 
chris_p said:
Thanks for the thread guys I took a deep read of all of it, my behaviour is definitely a bit of that of reckness naivity.
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I have to say Chris while you may not be a good example of how to measure drugs, you are a good example of someone that took some criticism with maturity and integrity. A lot of people would have just kept arguing. See, that is why we want you to be careful. You are a good dude. You even look like a friend of mine's brother. I thought you might be him until I saw you say South Africa instead of New Jersey. lol
chris_p said:
most of the people here seems to be those of the older kind who have already gone through the same kind of thing
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Like I told you in your mushroom thread, you are the guy that will be more careful and then when some younger BL'er will come in and you will set them straight in the future. You took the caring in a good way. Stay well man.
 
I posted a patent in which the QSAR of tianeptine homologues were tested for MOR affinity. Now I'm the first to make it clear that affinity ≠ efficacy but in this case it appears that the parent compound at least is technically a SUPERagonist. That may be why it seems to produce tolerance and dependence so quickly.

It's an unusual compound in that both isomers have more or less the same activity BUT it doe seem like quite a lot of people have remarked on how nasty the acute withdrawal syndrome is.

The opioid activity isn't well researched but it does sound like something best avoided. Technically interesting but something to be treated with a lot of respect out of all proportion to it's actual potency.
 
3DQSAR said:
The opioid activity isn't well researched but it does sound like something best avoided.
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There are statements like it hits a lot of receptors and is dirty. Of course most statements are just that, very general statements that are unsubstantiated. But I admit just from reading about it decided to avoid it.

I do notice they sell this too at the corner quickie stop. The owner said it sells better than 7-HO. Claims he gets complaints that the 7-HO is bunk, but what I think happens is it works good for some of the younger crowd that does not understand tolerance. But yeah another drug that should be a little harder to get than the corner store.
 
Do not be one bit surprised if tianeptine homologues turn up as RCs. it appears that modification of that long-chain carboxylic acid is one way to increase affinity. I took a look at the commercial synthesis and that chain is the LAST reaction and yes, I did check that the precursor was commercially available and since it's used to produce a medicine, in bulk it's CHEAP.

It's not competition for mad things like fentanyl or the nirazenes BUT I can well see snidey kratom blends containing homologues as, like those two classes, there are a lot of related compounds that are at least as active.

I've always considered the misrepresentation of a drug as a form of spiking people.

I'm not sure if there is even a presumptive test for tianeptine yet.

Oh, I've also read that tianeptine can polymerize. I know first reports of abuse came from Russia and people IVing the stuff were rapidly losing limbs.
 
chris_p said:
I don't actually recommend anyone do the kind of things I do, see it more as a documentation of the decisions I make and the consqeuences thereof

Thanks for the thread guys I took a deep read of all of it, my behaviour is definitely a bit of that of reckness naivity.. I've never once measured or tested a drug in my life have suffered some consequences because of it (3 hospitalizations, 3 day detainment in psych ward, 2 arrests) I came into bluelight thinking it would be a group of similar minded people and I have never really been into 'harm reduction' or any of that kind of thing my childhood also involved a lot of drug use including methamphetamine and mdma from age 14, most of the people here seems to be those of the older kind who have already gone through the same kind of thing, makes sense since Bluelight is an old ass forum, shouldn't have really expected anything besides deserved criticism
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My impression is that there are plenty of younger people here as well as us old farts. The harm reduction here can be a little strident, but you have to admit that it's a good idea. Just because, and to be a little more acceptable to the rubes.
There's a lot of good info here and 100% honest takes as well. Hey, you bought the sulphate from stuff you read here, I assume.
You'll be awright.
 
Is there a notable difference between the sulphate salt and the sodium salt? I only ask because I'm almost sure that it was the sodium salt that could polymerize.

It's not an issue as long as you avoid needles and at the end of the day it's always the freebase that crosses the BBB but I also noted that the hemioxalate salt is known, so that's three possible forms.

Yeah, be very cautious with all opioids. They do mess people up who don't respect them.
 
JackARoe said:
There are statements like it hits a lot of receptors and is dirty. Of course most statements are just that, very general statements that are unsubstantiated. But I admit just from reading about it decided to avoid it.
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A bit off topic, but why do you say it's " dirty"? I hear that adjective used for various drugs, like tramadol or kratom for eg, but I'm never sure what it means and whether it is more of a subjective opinion. I picture it meaning that it is a drug that has a variety of effects on various receptors, rather than working in just one way, but it seems like a lot of drugs would do that, particularly naturally derived ones with many alkaloids
 
3DQSAR said:
Is there a notable difference between the sulphate salt and the sodium salt? I only ask because I'm almost sure that it was the sodium salt that could polymerize.

It's not an issue as long as you avoid needles and at the end of the day it's always the freebase that crosses the BBB but I also noted that the hemioxalate salt is known, so that's three possible forms.

Yeah, be very cautious with all opioids. They do mess people up who don't respect them.
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I've only ever worked with the sulphate salt and I'm typically incredibly opioid sensitive. I must've had a shit batch because I was routinely sipping 200-300mg to feel the equivalent of 80-100mg of mitragynine, but I was also making all my tianeptine into "tianeplean" so maybe that was the issue. Acid did the same thing, it was far weaker as a syrup for some reason.
JackARoe said:
There are statements like it hits a lot of receptors and is dirty. Of course most statements are just that, very general statements that are unsubstantiated. But I admit just from reading about it decided to avoid it.
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I can't recall the name of the company that was originally pushing it and trying to patent tianeptine but they're notorious for lying on their pharmacology reports, afaik tianeptine is just a pretty simple MOR agonist when anaylyzed by third parties but I'm not positive. It definitely felt unique, and has a unique synergy with psychedelics, it goes super well with lysergamides and phenethylamines compared to tryptamines where it's kind of a nausea factory (which typically I'm quite resistant to).
 
chippermonk said:
A bit off topic, but why do you say it's " dirty"? I hear that adjective used for various drugs, like tramadol or kratom for eg, but I'm never sure what it means and whether it is more of a subjective opinion. I picture it meaning that it is a drug that has a variety of effects on various receptors, rather than working in just one way, but it seems like a lot of drugs would do that, particularly naturally derived ones with many alkaloids
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yeah I am sort of parroting what I hear on the boards. It has been said alcohol is dirty too and honestly I too have wondered what that actually meant. Like maybe someone can define a clean high?
 
"tianeplean" - I intend to steal that term so it may well end up in a HR booklet and online (Linnell Communications).

Ethanol intoxication is complex. It's action on the brain is complex and not limited to the GABA receptors although it appears that the POSITIVE effects are all mediated by said GABA receptors.
 
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