Opioids Tianeptine Has Completely Ruined Opiates for me

[alfaromeo1979]

Here is my story. I’ve been doing Tianeptine religiously for the past 8 years (4 doses per week, 180mg per dose). At first, I had no issues combining it with other opiates.

A few years ago, I travelled to the US and purchased the most powerful kratom extract on the market (kratom enthusiasts will be familiar with the main extract supplier in the US, I’ve used this tincture before and it always knocked me off my ass). To my disappointment, I noticed ZERO effect.

Being the fiend that I am, I continued using high doses of the kratom extract every day for a week, with no results. To my surprise, on the flight back, I was hit with all the physical symptoms of opiate withdrawal (restless limbs, cold sweats, diarrhea, etc.) but none of the mental symptoms of withdrawal.

Since then, I’ve used countless other opiates (Tramadol, poppy seed tea, codeine) with zero effect. These drugs all used to work before. I’ve tried them as much as one week after my last dose of Tianeptine, with no success. Not even a slight mood lift.

I’ve researched other users’ experiences on this forum and came across multiple users who reported that drugs like morphine and bupe had no effect after building up a tolerance with Tianeptine (not even to reduce withdrawals).

What is going on here? I’ve never been off Tianeptine for more than a week. I always assumed that one week was enough to reset my tolerance, but unfortunately that does not seem to be the case.

How can Tia completely negate the effects of other opiates? I always thought of it as a weak opiate. Any feedback, experiences, or insights would be greatly appreciated. Thanks!

 

[Deleted member 585202]

Did you experience dependence or withdrawal from using tianeptine 4 days per week?

When is the last time you used tianeptine?

You feel zero effects at all from other opioids? Or just heavy tolerance?

Potent agonists can cause extended tolerance. I recall after I quit using synthetic cannabinoids I was unable to get high from regular weed for 4-5 weeks. No matter how much I took. But then after 5 weeks suddenly my receptors were back to normal and I could get high again.

As they say, time heals.

 

[WellTram]

Tianeptine Is weak but if you take enough, it's just like oxycodone.
Tramadol probably doesn't work for you because of your tolerance. Tianeptine doesn't inhibit cyp2d6, i used to take them together ... If i were u, try experimenting with dextromethorohan for a few weeks.

 

[Deleted member 585202]

Tianeptine Is weak but if you take enough, it's just like oxycodone.

It's only weak at therapeutic doses. At supratherapeutic/recreational doses it acts as a mu receptor super agonist. I'm sure it really does a number on the receptor.

The fact that it acts in this manner at supratherapeutic doses was somehow not discovered as the drug was being developed, which is why it's unscheduled. Frankly I don't think the drug would have ever been pushed to market if they figured that out.

 

[KurtAurelius]

A week has never been enough to lower my opioid tolerance to baseline: it does something but for me 2 to even 3 months is more akin to “baseline”

A week ago I did 150mg DHC dosed 2x a day, and my tolerance was so low I actually chundered after smoking a cigarette.

This was even after I did 210mg 2x a day codeine the week before, (I had an another 420mg or so total dose a few days before that aswell).

Today I’ve done the same dose of DHC, effect is 80% in the positives say from before, but itching and nausea is absent, I’ve thankfully not thrown up after smoking lol.

The codeine I did before the DHC, was after a 2-3 month gap, and my first dose of 180mg codeine provided full effects from my experience, as someone who was abusing DHC 3x a week at 400mg on average 2-3 months ago.

Only anecdotes, so nothing conclusive I can give you. But a good start is atleast ensuring a drug has fully left the system ( 4 half life’s is what I’ve heard but unsure if 100% correct in all contexts)

Then I’d wager a flat 4 weeks minimum on top to allow receptors to function more to baseline but still sounds to generous to me.

I can speculate that living as well as possible will allow faster baseline, achieving all nutrients at thriving levels not just requirements, and plenty of exercise to get the body able to release and function from endogenous endorphins.

Fancy words for not alot of concrete info but there’s my 2 cents.

 

[jasperkent]

The fact that it acts in this manner at supratherapeutic doses was somehow not discovered as the drug was being developed, which is why it's unscheduled. Frankly I don't think the drug would have ever been pushed to market if they figured that out.

I worked with a gal who'd been on heroin for years, quit, and then later got on tianeptine.
She said tianeptine withdrawal was harder on her than heroin had been.

 

[WellTram]

It's only weak at therapeutic doses. At supratherapeutic/recreational doses it acts as a mu receptor super agonist. I'm sure it really does a number on the receptor.

The fact that it acts in this manner at supratherapeutic doses was somehow not discovered as the drug was being developed, which is why it's unscheduled. Frankly I don't think the drug would have ever been pushed to market if they figured that out.

My doc was providing me with a huge amount of tianeptine as a second, supportive AD to make my main ad potentiated but after one of that summit of psychiatrists that they sometimes have ( usually as a part of the expensive trip somewhere ) he completely stopped prescribing it because guys from pharmaceutical company suddenly discovered it Is effective full mu-opioid receptor agonist with additional dopamine raising mechanism so now it's considered short acting opioid+dri hybrid and it Is no longer the very well tolerated and effective antidepressant :D

Since than, if u want prescription for AD they always have to give you citalopram, if u complain than escitalopram and ONLY after months of pushing citalopram to everybody with depression you can try other SSRi, than SNRi, than atypicals starting with trazodone and only after being put on all of this meds they are willing to prescribe you mirtazapine and vortioxetine.

 

[Them Witches]

I do not know if this will help. The details kind of jump around but it is experience of a long history of opiate/opioid treatment & other Alpha2, benzo. sedative/hypnotic, Rx anti-histamine, GAD drugs, gabapentinoid, and centrally-acting skeletal muscle relaxants.

the way I make my opioids work better is this & it has been working well for decades :
-- only taking opioids with a high bioavaliablity PO (oral) & long half-life (full-life)
-- taking them with clonidine (strong alpha2 drug), benzos (Ativan), gabapentinoid, strong anti-histamines
-- avoid IV use and boofing b/c the brain will desire the same "reward effect"
-- drinking grapefruit juice regularly, drink plenty of water daily, diet well including fruit smoothies *** this is important in so many ways and helps the brain stay happy ***

-- exercise daily, shower regularly, maintain a positive effective daily routine
*** this will help keep the brain happy and will provide natural cognitive improvements & accomplishments. Solely relying on opioids to provide what is needed daily will only increase the brain's desire for them and nothing else will work except that ***

-- taking cimetidine 30 mins before Oxycodone and Methadone dosing
*** Cimetidine increase blood plasma levels of Oxycodone ***

-- taking Tums 15 mins before dosing opioids with Methylpredisolone
*** IMO, Tumbs keeps the opioids in my liver longer & Methylpredisolone helps the opioids cross the blood brain barrier easier & faster

-- Dextromethorphan 40mg at the same time of dosing opioids
-- if I can I dissolve opioids under my tongue after crushing them up. keep them there are long as possible while gently drinking grapefruit juice in small sips


7-OH stops working very quickly if taken every day and the withdrawals will come just like opioids. Too costly for what it does which the effects wear off too quickly

In the morning, I take a double dose of Oxycodone (60mg) with Methadone (10mg) to stop waking withdrawal. Then every 4hrs take Oxycodone 30mg. I take the Methadone 10mg every 8hrs after that. I need to address physical dependency after 40 years of pain management. I know that by adding Methadone to daily dosing helps prevent the need to increase the primary opioid. I can go 2 years without having to increase Oxycodone with adding Methadone and dissolving Oxycodone under the tongue. Many people with lower tolerances find dissolving Oxycodone under the tongue too strong. It is stronger and the body absorbs more of the drug causing higher blood plasma levels and more of the active ingredient crossing the blood brain barrier.

Tianeptine is an opioid agonist, meaning it activates the same opioid receptors in the brain as traditional opioids. When both tianeptine and other opioids are used, they compete for the same receptors, which can reduce the overall effectiveness of the other opioids. the issue is these type of drugs have a heavy effect on dopamine and serotonin production and compete against the opioid's action in the brain. This is why I take my Zoloft at bedtime and I take my 1st Busbar dosage at lunch after the opioids have addressed my dependence needs and pain needs. I take the 2nd Busbar dose at bedtime.
I feels less effect from the SSRI / anti-depressant drugs competing with opioids because I also take Clonidine & Ativan pre-lunch time and both again in the evening at dinner. I take Gabapentin at lunchtime and again at dinner time. 1 hour before bedtime I take Vistaril PAM and Lunesta 30 mins before bedtime.
I always take my meds before I eat giving them plenty of time to get into my system.

 

[ResistNWO1984]

Here is my story. I’ve been doing Tianeptine religiously for the past 8 years (4 doses per week, 180mg per dose). At first, I had no issues combining it with other opiates.

A few years ago, I travelled to the US and purchased the most powerful kratom extract on the market (kratom enthusiasts will be familiar with the main extract supplier in the US, I’ve used this tincture before and it always knocked me off my ass). To my disappointment, I noticed ZERO effect.

Being the fiend that I am, I continued using high doses of the kratom extract every day for a week, with no results. To my surprise, on the flight back, I was hit with all the physical symptoms of opiate withdrawal (restless limbs, cold sweats, diarrhea, etc.) but none of the mental symptoms of withdrawal.

Since then, I’ve used countless other opiates (Tramadol, poppy seed tea, codeine) with zero effect. These drugs all used to work before. I’ve tried them as much as one week after my last dose of Tianeptine, with no success. Not even a slight mood lift.

I’ve researched other users’ experiences on this forum and came across multiple users who reported that drugs like morphine and bupe had no effect after building up a tolerance with Tianeptine (not even to reduce withdrawals).

What is going on here? I’ve never been off Tianeptine for more than a week. I always assumed that one week was enough to reset my tolerance, but unfortunately that does not seem to be the case.

How can Tia completely negate the effects of other opiates? I always thought of it as a weak opiate. Any feedback, experiences, or insights would be greatly appreciated. Thanks!

A friend of mine was taking 3-5 g’s of T daily; it took them a month or so until it started back, but not as strong as before. That took about 6 months and it eventually came back. It’s strange that happened to them, but that’s how it goes with T it sounds like