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Theoretical meth and coke synergy question.

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Bluelighter
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We all know that cocaine blocks the effects of methamphetamine due to its blocking the reuptake of dopamine and meth enhancing the reuptake right?

Lets suppose you have pure d-meth and pure cocaine. If you did the meth until you were fairly high, and then waited 4-5 hours for the effects to simmer down, then snorted the cocaine, wouldn't it have some sort of synergy? The meth would bring lots of dopamine in, and then the cocaine would trap it. Is this correct or is there something that I don't understand??
 
>>We all know that cocaine blocks the effects of methamphetamine due to its blocking the reuptake of dopamine and meth enhancing the reuptake right? >>

Er...both drugs block reuptake, but meth also stimulates release and is a direct agonist.

>>The meth would bring lots of dopamine in, and then the cocaine would trap it. Is this correct or is there something that I don't understand??>>

I guess this would largely depend on how much dopamine is still floating about between you synapses....I'm thinking that when they meth has simmered down, most of the dopamine would have been metabolized into nor-epi' or catabolized entirely.

I dunno...I think I may be too ignorant to comment on this, really. :)


ebola
 
ebola! said:
>>We all know that cocaine blocks the effects of methamphetamine due to its blocking the reuptake of dopamine and meth enhancing the reuptake right? >>

Er...both drugs block reuptake, but meth also stimulates release and is a direct agonist.

>>The meth would bring lots of dopamine in, and then the cocaine would trap it. Is this correct or is there something that I don't understand??>>

I guess this would largely depend on how much dopamine is still floating about between you synapses....I'm thinking that when they meth has simmered down, most of the dopamine would have been metabolized into nor-epi' or catabolized entirely.

I dunno...I think I may be too ignorant to comment on this, really. :)


ebola

No, you know what your talking about so your not ignorant at all. I didn't know that meth also blocked the reuptake of DA.

Why does cocaine block the effect of amphetamines?
 
Cocaine does not block the effects of amphetamines.
Amphetamines mode of action, and how it reacts/duration etc.
Is independant of cocaine....as far as i knew.

I have never seen cocaine block amphetamine's effects....or render it useless either in experience....


and....sure if you wait until you crash. and do a line of coke...your hit back up for a minute......then crash.
Although, dangerous on your heart. Becaues "feeling the effects" being over 4-5hours has little to do with what/when the brain is still in process of doing.. o r adjusting to.
 
We all know that cocaine blocks the effects of methamphetamine due to its blocking the reuptake of dopamine and meth enhancing the reuptake right?
No, methamphetmine reverses reuptake. Think about it, if methamphetamine enhanced dopamine uptake, then it would cause less dopamine to be in the synapse and it wouldn't be fun.

Meth is not a direct agonist of dopamine receptors at any reasonable concentration.

Why does cocaine block the effect of amphetamines
Because amphetamine needs to move through the monoamine transporter in order to cause the neuron to release neurotransmitters. By blocking the transporter, cocaine stops meth from moving through, and hence stops it from acting.
 
BilZ0r said:
No, methamphetmine reverses reuptake. Think about it, if methamphetamine enhanced dopamine uptake, then it would cause less dopamine to be in the synapse and it wouldn't be fun.

Meth is not a direct agonist of dopamine receptors at any reasonable concentration.

Because amphetamine needs to move through the monoamine transporter in order to cause the neuron to release neurotransmitters. By blocking the transporter, cocaine stops meth from moving through, and hence stops it from acting.

Lol yeah that would suck. Ok I think I get it now, cocaine blocks it from getting out ANd in?
 
>>Meth is not a direct agonist of dopamine receptors at any reasonable concentration.>>

Yeah, THIS is why I wanted someone more knowlegeable than I to post. :)

ebola
 
Ok I think I get it now, cocaine blocks it from getting out ANd in?
Cocaine inhibits the reuptake of neurotransmitters, from the space outside the cell, into the cell.
 
Sorry to dredge this topic up again, but I wanted clarification on whether it would be sensible to take coke then, once the immediate effects of it had worn off, take base?
 
i take coke and meth together plenty, i havnt noticed them cancelling out each others effects - and i thought a huge percentage of the coke ppl get in the states etc was cut wiv amphetamines anyway......
 
^and there goes the advanced part of the discussion.

BilZ0r, what's the most specific SDARI that you know of?
 
the bottom line is this: for a pure meth experience, don't do coke for an hour before, during the run, or until well into the crash.

there are substances that potentiate meth, most of which are unpleasant at best and seriously harmful at worst.

if you feel you need a stronger meth experience, seek out higher quality meth. coke gets pretty lost in a full on meth run. plus, heart attack city.
 
The most specific SDRI? In clinical use it's buproprion I think. In general I thought it was GBR 12783, which is ~100x selective of SERT and NET; I know it's not GBR 12909 or Mazinol, which are only ~10x selective. They're are probably more selective ones out there, but I don't know if any of them are available from the catalogue.
 
GBR12909 and mazindol are listed by a few of the major companies, although mazindol is a dea schedule iv substance. I can't find GBR 12783 listed anywhere.

Correction; GBR 12783 is listed by a few of the major companies.
 
Toxxxs has them - they are not considered a 'source' i hope.

GBR 12783 looks rather interesting, although i cant seem to find any human info on it though.

wonder how it would stack up against 1-(3,4-methylenedioxy-phenyl)-2-pyrollidin1-yl-pentan-1-one?
 
"toxxxs" sutble... lol. Yeah, I'm closing this. If people are interested in discussing the pharmacology/physiology/chemistry of DAT inhibitors, start a new thread.
 
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