I'm not big on stimulants, but every one I have ever tried made me feel like complete and total shit while it was wearing off.
Alcohol has a very nasty come down for me also, puking, spinning room, headache, and the shits. I had a 3 day hangover one time and I haven't been drunk since. Alcohol is a nasty nasty poison.
I know this isn't really a comedown, but withdrawing from opiates is absolutely terrible. I'm sure you all know the symptoms so I won't go into it. The sickness hasn't stopped me from doing them, although I have made major cut backs.