The truth about opiate potentiators

[TDogUSA]

Where can one find Kratom?

 

[fastandbulbous]

Cimetidine inhibits bothe CYP2D6 and CYP3A4, so it's not going to be much good for codeine or any drug with a 3-O-methyl group as that methyl group is removed by CYP2D6. For drugs with said O-methyl group, you just want something that inhibits CYP3A4, like grapefruit juice, as it's responsible for the removal of the N-methyl group (which results in codeine to norcodeine, morphine to normorphine etc) and removal of said N-methyl group results in compounds that have much less opiate activity.

If instead the drug has a 3-hydroxy group (like morphine etc), then cimetidine is useful as CYP2D6 plays no role in the metabolism of these drugs.

So basically:

For codeine; dihydrocodeine; hydrocodone etc you want grapefruit juice, but not cimetidine

For morphine; dihydromorphine; hydromorphone etc you can use either grapefruit juice or cimetidine

 

[oneswtwld]

I made some poppy pod "food" a few days ago and drank a 10 oz glass of grapefruit juice about 45 minutes before...

I probably used about 5-10 (not really sure) large pods...

I was absolutely wasted for the entire day (I ate it @ 10 am)

I felt it the next morning...

IT was awesome

I'm definately doing it again tomorrow

 

[garuda]

I'm definately doing it again tomorrow

DUN DUN DUN

Writers call this foreshadowing

LOL just messing with you.

 

[center]

^ Properly said, chap!

To add my comments...

A friend of mine told me he noticed placebo>effect on grapefruit juice with oral oxycodone.

This is not my area of mastery. Thankfully.

 

[mulberryman]

All I know is grapefruit juice gives me heartburn and cimetidine helps prevent that nicely. Poppies are good for when you got the shits.

 

[center]

That's so American. Take one thing to cure another, and another...another. I love this never ending chase.

 

[mulberryman]

Well that's the fun of running. ..or as someone once said, "Run fer fun, what the hell kinda crazy fun is that?!"

 

[klowns]

grapefruit juice then a recreational dose of DXM equals send me to jesus-land
grapefruit and poppy seed tea ( REALLY good seeds) equals my favorite opiate high in existence
grapefruit juice and klonopin-i notice no difference
cimetidine, dxm and poppy pods equals way better stronger buzz, and lasts longer
dxm plus hydro or (insert any other opiate) equals amazing buzz plus you dont build tolerance in the same fashion you normaly would. its fuckign amazing
prometh plus codeine equals bliss

what the fuck do you mean potentiators dont work? lmao.
peace

 

[klowns]

poppy seed tea is nto worthless it is the best high i have ever had. sadly all the good seeds seem to have diassapeared from the fucikking market and they are all junk now. if you would have gotten into the shit a few years back, you would realize taht there is no need to buy oxycodone or anything like that ever agian at a buck a mg. when ONE pound of GOOD seeds for 3 bucks gets you as high as 150-300 mg oxy (on the upper end if you use grapefruit juice)
and it lasts fucking forever you wake up still baked, and you can keep using the same dose. etiehr one or 2 pounds for me, but with those good seeds, my buddy has NEVER taken over a QP. he usualy only uses 2.5-3 ounces tops cause it fucks him up too bad and he was an oxy junky

 

[moeburn]

For me, if I dont drink 500ml of white grapefruit juice 45 minutes before I drink poppy seed tea, I don't get high. It has to be white grapefruit, and it has to be no more or less than 45 minutes (for my BMR).

WARNING: Don't make a habit of drinking that much grapefruit juice too frequently. Stomach pains are real, not just withdrawal-induced. Tums are an absolute godsend. Vitamin-C overdose = lots of diarreha.

 

[manic_panic]

II've come to the conclusion that any antacids potentiate them, it doesn't exactly have to be white grapefruit jucie or Cimetidine/Tagamet. From my experience I have taken Tums and even Maalox for most profound effects.

 

[DexterMeth]

Generic tagament is $4.99 for 50 200 mg tablets, about the cost of a xanax bar for 25 better opiate experiences.

^Uh, that's a VERY VERY good price for the quantity of cimetidine you're talking about. Around here, it's like ~$10(+ ..a lot of times) for a blister packet of, i dunno, i think like only 24 (at the MOST), 200mg tabs.

 

[mulberryman]

Yeah unfortunatly, like nearly all the great deals around here, it means buying everything at Wal-Mart, which can leave you in a state of moral dillema. The internet is still a good option though, if you buy in bulk quantities enough to offset the shipping costs.

 

[DexterMeth]

^That's a good point. I myself wouldn't mind shopping at wal-mart though. My other personalities "Just don't give a fuck"(Dre and Snoop saying that one...lol)

 

[got beans?]

wait 1 hour after taking cimetadine/grapefruit to take your opiates. also, eating a fresh grapefruit is a lot more effective than drinking processed juice (which rarely contains much real grapefruit juice). i find 25mg of benadryl adds a lot to it without almost any added sedation/side effects.

 

[PcChip]

Just to offer a subjective experience but cimetidine in the amount of 800mg used before PST actually degraded the experience, something just seemed off and the high felt incomplete. This was a surprise as I was expecting potentiation.

Same for me, two cimetidine ruined five 10mg hydrocodones for me once about 6 months ago, so I never tried it again.