I have done the loperamide trick many times. Loperamide is an opiate, originally developed as a pain med. It takes a few hours to start working and lasts something like 5 or 10 times as long as normal opiates. It doesn’t provide fast or sufficient pain relief but a big side effect is that it really slows your digestive system, SO they repackaged it as an ‘anti-diarrheal’ med about 30 years ago. In low doses it’s great to stop diarrhea but in large doses it’s awesome to stop opiate withdrawal. I have done as much as 60mg x 4 per day. It makes my blood feel really dirty so there’s a bit of inspiration to taper off it as quickly as possible. There’s evidence that high-dose long-term use can cause serious heart problems. ALSO, it pushes it’s way into your opiate receptors and renders standard opiates almost useless (temporarily raises your tolerance for all other opiates significantly). It does have a wicked long half-life so acute wd from long term use can last for several weeks. Based on my own use this is how you can expect it to work if you’re using it to quit other opiates:
Plan on starting about 1/2 to 3/4 per day of loperamide compared to your current opiate. (Example: if I’m using 200mg/day oxycodone, I’m starting with 100-150mg/day loperamide in 3-4 doses). It takes 4 hours to kill wd’s. 4-5 days at that dosage, then cut back at a rate of about 25% of today’s dose every 4 days. It’s a game of percentages, not milligrams. And your math is based on what you’re taking on that day, not based on where you started. (Example: starting with 100mg/day loperamide and cutting back 25% every 4 days:Day 1-4 =100mg, days 5-8=75mg/day, days 9-12=55mg/day, days 13-16=41mg/day, days 17-20=30mg/day,etc) Every drop of 25% is math based on whatever dosage you’re at in that moment.
These numbers are only a starting point. You might need to go more slowly or start at a larger dose. You may also be able to go faster (i.e. starting with less and cutting back more). Just know that you will feel dirty from the inside and you will be horribly constipated. Laxatives are a must and definitely eat plenty of things like raisins and other fruits that will help you pass a bag of bowling balls. And if you’re going down that path you absolutely need to get off loperamide as fast as you can stand it. If you think the wd’s from your current opiate are bad..... loperamide is way worse and lasts for months.
In the USA loperamide is over the counter, but they stopped allowing large packages a few years ago. I found it online in bottles of 100 pills, but at the store the largest package is only 16 pills(2mg each pill). Cool thing is that it’s available in any pharmacy and most grocery stores. Not cheap but 100x better than illegal drugs. Very convenient when traveling.
The biggest problem with loperamide is that your plan MUST be to use it to quit all opiates. If you use it to ‘temporarily’ quit, you will actually be screwing yourself. I did it to bridge myself to my next prescription and really only raised my tolerance for oxy by 4 or 5 times. The end result was that I ran out faster the next month. PainfulOne had the same experience and it took several months to get back to where her normal prescription worked again. And if you wind up dependent on lope.... you’re looking at months of serious withdrawals.
Last edited:
)
And yes may be they would impact the ckecking test on markers
piates