Phenethylamines The Small & Handy 2,6-Dibromomescaline (2,6-BM / DBM) Thread

[Psychestim]

A while after I got my first result I paused my experimentation with 2,6-DBM and waited for a second batch to land in my hands in the hopes of receiving a pure(r) product.
And indeed, a new batch of DBM magically found its way into my possession, but this time it was prepared as the hydrobromide salt. The powder was very shiny and looked much more visually appealing than the first sample. Out of excitement, I immediately continued my titration and took 20mg on an empty stomach. I noted no effects.
Anyway, after this trial I handed in a small amount of this powder for lab-testing and two days ago I received my result.
I was surpised and disappointed to see that my sample was again, adulterated.

submitted as: 2,6-Dibromomescaline HBr
expected: 2,6-Dibromomescaline HBr (not quantified)
unexpected: Unknown compound (not quantified)
remark: This sample contains a significant amount of a compound we could not (yet) identify, alongside 2,6-dibromomescaline. We know for sure that the unknown substance in your sample is not 2-bromomescaline

I just heard back from the testing facility and to my great surprise they told me that my sample is in fact NOT adulterated! I‘ll keep it short, but according to their pharmacist the first analysis through LC-MS/MS (ion trap MS) and LC-UV was a little inconclusive so they opted for a more precise mass spec called MALDI-HRMS which showed the molecule ion peaks much more clearly and they can now say with absolute certainty that what I have is 2,6-dibromomescaline, and only that. No other components were found.

The titration continues tomorrow with 40mg of the hydrobromide salt!

Wanna hear another good thing? I also received ~500mg of the monobrominated version today. I’ll hand some of it in for another lab-analysis on Friday and should have the results in the upcoming week. Really looking forward to combining the two, good thing my first batch is a 1:3 mix of BM/DBM.

 

[Psychestim]

So far my experiences with the HBr salt yielded the following intensity levels on the Shulgin rating scale.

1mg: -
5mg: -
10mg: -
20mg: -
40mg: ±
60mg: +

Next trial will be at 80mg, probably next week. I can’t really characterize the effects as of yet and I also don’t want to spoiler anything because I’ll release a collection of reports once I’m done escalating my doses. What I’m gonna say is that it’s definitely not as potent and visual for me at 50mg as the one Erowid report suggests.

 

[izo]

nice, some new data. sad that blacklight went down without knowing who has the forum data, it had some unique information. i remember an early report of 2-bromomescaline. all i know that it was a fair bit stronger, dose might have been around 140mg but i would have to guess.

 

[Psychestim]

2,6-Dibromomescaline - Bioassay - Brominated Blandness

The following post is an extensive overview of the psychedelic drug 2,6-Dibromomescaline. This post is very thorough and features a collection of trip-reports and plenty of other information. Because of this, there are some repetitive and redundant observations. If that bothers you, just skip to...

bluelight.org

I decided to still release the full titration, even though it might be a little boring to read, just because there is so little information on this compound. I hope some of you still find it interesting. I'm really looking forward to release a report for 2-bromomescaline (one bromine less) because this one seems to be a winner compared to the dibromo version.
I wish you all a great day!

 

[tryp2fun]

Your experience is very similar to mine. Threshold at 24 mg (HCl salt), 48 mg gave a mild effect, 60 mg still mild, 90 mg a little stronger intoxication. Still, nothing exciting, completely missing the emotional magic of mescaline. I'm interested to hear more about the 2-halos.

 

[ecstacylover]

I had 27mg of the ~75:25 DBM:2-BM mixture left and took it with a glass of water yesterday evening. I'd had 800mg of phenibut earlier in the day, and also a 25mg d8-THC edible an hour before. Also had a couple grams of piracetam when I woke up and about 300mg of caffeine throughout the day.

Very mild in terms of visual disturbances. Positive mood, music appreciation and introspection were enhanced. Very nice euphoria, although it wasn't present for the entire experience. Mild paranoid thought-patterns at a couple points, which I imagine was due to the d8. Overall an enjoyable and accommodating experience, and one that's unique from just phenibut+d8/9-THC. Fell asleep around 2 AM to some very restful sleep and mild but pleasant afterglow this morning.

Would definitely repeat this combo if I had more of the mixture, probably at 50-75mg of the mixture and 600-800mg of phenibut, and leave the d8 out of the picture.

 

[Allylbenzene]

So far my experiences with the [2,6-Dibromomescaline] HBr salt yielded the following intensity levels on the Shulgin rating scale.

1mg: -
5mg: -
10mg: -
20mg: -
40mg: ±
60mg: +
...
What I’m gonna say is that it’s definitely not as potent and visual for me at 50mg as the one Erowid report suggests.

Your experience is very similar to mine. Threshold at 24 mg (HCl salt), 48 mg gave a mild effect, 60 mg still mild, 90 mg a little stronger intoxication. Still, nothing exciting, completely missing the emotional magic of mescaline. I'm interested to hear more about the 2-halos.

For future reference, these 2-/6- mescaline analogs aren't necessarily as good as plain mescaline because (imo) they are analogs of a weakly active prodrug. In this case it is best to keep the prodrug intact which allows it to reach its full potential. The same goes for modifications at α, ß, N and the '3, '4, '5 substituents.

 

[xdrc]

For future reference, these 2-/6- mescaline analogs aren't necessarily as good as plain mescaline because (imo) they are analogs of a weakly active prodrug. In this case it is best to keep the prodrug intact which allows it to reach its full potential. The same goes for modifications at α, ß, N and the '3, '4, '5 substituents.

2-bromo-6-chloromescaline was regarded as a very rich compound by someone who made it, in the leagues of 2C-E et al. I'd encourage people to not just dismiss them when there are only a sparse handful of bioassays.

 

[Allylbenzene]

2-bromo-6-chloromescaline was regarded as a very rich compound by someone who made it, in the leagues of 2C-E et al. I'd encourage people to not just dismiss them when there are only a sparse handful of bioassays.

For sure explorations of analogs is "good". I was simply highlighting that the classic mescaline experience is specific to the 3,4,5-TMeO motif which I'd consider a prodrug (evidence indicates as such). In this context, a 2-/6- mescaline analog is different to mescaline for more reasons than simply "it's mescaline with added 2-/6-x".

 

[xdrc]

I was simply highlighting that the classic mescaline experience is specific to the 3,4,5 motif which I'd consider a prodrug (evidence indicates as such).

There is currently only hard evidence for mescaline being a weak partial agonist with low brain penetration, and no hard evidence of it being a pro-drug. But of course I invite you to think harder about what it should metabolise into - so far the candidates you showed me didn't look so promising, but of course they have been untested so who knows. I do find the suggestion that the main psychedelic effects come from anything but mescaline a bit hard to believe (5-HT2AR tunnel vision ), but I am open to the possibility that there could be metabolites - potentially even some which we have so far missed - which contribute meaningfully to the experience. You may say that evidence indicates as much (and as I recall the main piece of evidence is an isolated forum post), but there is solid evidence for this theory of yours not being the case. I do agree with your notion that it is good to think out of the box however and to crush dogma. I do not agree with how you are trying to push a new dogma with arguably flimsy foundation. But let's not argue about that, I made my point here.

 

[Allylbenzene]

There is currently only hard evidence for mescaline being a weak partial agonist with low brain penetration, and no hard evidence of it being a pro-drug.

Sure - none of the academics in question seem aware nor considerate of how it may act as a weakly active prodrug; dogma resigns and constrains. As such, you can't find any hard evidence which would meet your requirements. By now it's an "obvious truth" that mescaline is the active drug so why would any scientist bother to think otherwise?

But of course I invite you to think harder about what it should metabolise into - so far the candidates you showed me didn't look so promising

I've not shown you anything which I consider to be the active metabolite(s). As biosynthesis is implicated in their production, and as 70% of the biosynthetic steps remain unelucidated, the entire thing remains concealed in a fog which academia cannot see beyond.

I do find the suggestion that the main psychedelic effects come from anything but mescaline a bit hard to believe (5-HT2AR tunnel vision )

'2A tunnel vision' is unrelated to the notion of mescaline being a weakly active prodrug. Someone with '2A tunnel vision' believes that the beneficial effects of eg LSD are solely due to its 2A properties, while the rest of its polypharmacology is detrimental/an impedance. I discussed this with an employee of Nichols company (2A Biosciences) and this person was the epitome of '2A tunnel vision'. You aren't so close minded so I doubt you have '2A tunnel vision'!

...but I am open to the possibility that there could be metabolites - potentially even some which we have so far missed - which contribute meaningfully to the experience. You may say that evidence indicates as much (and as I recall the main piece of evidence is an isolated forum post), but there is solid evidence for this theory of yours not being the case.

Whilst academia cannot see beyond the fog surrounding the (unelucidated) biosynthetic steps referred to earlier, and existing dogma severely constrains an academics perception — beyond academia many have insights into what might be occurring. I happened to be on the forum (in 2011, where that forum post originates) where this prodrug notion was discovered by accident, technically it was rediscovered. I say rediscovered because we found a webpage which detailed it fully, so obviously someone knew.