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Opioids **The Oxycodone Mega Thread.** - Can't find your thread? Its in here.

Well...I've waited about an hour after snorting the first OC20. Time for the second. Crazy how high my tolerance must be (or maybe not).
 
2point2ek said:
what are some home remedies for overcoming withdrawal? trying to stop but its really killing me.. ive never gone threw withdrawal before (i didnt even think I used alot (30mgs a day) but i had to call out a second day at work for flu-like symptoms..

maybe i have the flu? or maybe its withdrawal...
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The worst withdrawals I have ever experienced was after quitting a 12-month, 20mg/day Oxycontin habit. That was my first ever experience with opiates. It caught me so off guard that I started thinking exactly as you are - "Wow, maybe I really am sick? Like maybe I coincidentally caught something at the same time as I quit taking my meds?" But that's just wishful thinking. It really is just the withdrawals. After quitting that time, I was so bad, I can only describe it as near death. I was bed-ridden for the first 3 days, then I seemed to get better and was walking around for days 4-5, but then the psychological part, insomnia, and RLS started to worsen and I went right back to being bed-ridden. I spent a solid 7 days lying in bed, feeling like I was dying. That was truly the most unexpected and worst experience of my life. It was about 3 weeks total before I was back to normal functioning.

Strangely enough, I have abused my meds for months on end and then gone through withdrawals many times since then, and never has it been as bad as that first time. In fact, I've withdrawaled off of a 2-month 120mg/day Oxy habit, and I only had slight withdrawal symptoms for about 5 days. So I don't know, it's like you have to pop that withdrawal cherry, then you're good to go. Plus the experience is so miserable that it will really teach you about when to call it quits when you start getting out of hand. For example, I've never abused my meds for more than a month or two at a time after that horrible experience. I definitely learned my lesson.

And as for what makes it better, some things that are definite life-savers for me: Loperimide, Clonidine, and Phenobarbital. Since you're withdrawaling off of a "downer," you'll experience rebound effects similar to "uppers" (i.e. tachycardia, hypertension, etc.). So fighting the withdrawals with any downer should help out (i.e. benzos).

And my best advice for you, is what to avoid. These absolute WORST things for "combating" withdrawals: alcohol and diphenhydramine. My God, alcohol and diphen make the withdrawals so much worse. I remember I kept thinking "No the alcohol is a downer, it will help." But it DOESN'T. Not only does it compound the insanely restless legs, but it compounds the insomnia too. And diphen makes the restless legs a hundred times worse, to the point where you have to jog around the block all night just because your legs have to keep moving. If your first-time withdrawal experience is anything like mine, which it sounds like it might be, then be prepared for your life to be devastated for a solid 2 weeks. And be prepared to go for 3-4 days at a time with out sleeping a wink.

Honestly, my best advice would be to use Vicodin or Norcos to taper for at least 5 days first. Just take enough to keep your withdrawals at bay, and your mind will start to de-fog. Then, when you quit the hydrocodone as well, it will be so much easier. I always detox with Vicodin now, and it keeps me functional during the process. Functional enough to keep working that is.
 
Anyone know if the "Microwave Method" works for the Mallinckrodt brand Oxy's? it seems to work with the Teva ones but I haven't heard it workin with the Mallinckrodt brand, they gel up pretty bad so I guess it'll be parachuting for now
 
Well, I read the whole thread and didn't see anything about the oxys I bought yesterday. They were 80s and green but instead of "oc" there was an M. I got good and high, and have had the unfortunate vomiting sessions today. I don't get sick doing two 20s but I get sick doing half an 80. I just wanted to read through here and see if anyone else has seen these, but I've surfed the whole thread...
 
txchick007 said:
Well...I've waited about an hour after snorting the first OC20. Time for the second. Crazy how high my tolerance must be (or maybe not).
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OC20s are my absolute favorite thing this side of ecstasy. I buy 10 at a time and when I look at those little pink things in the baggie I'm like a kid whose been waiting in line to ride the Pirates of the Caribbean and I've finally made it to the front of the line. <3
 
txchick007 said:
Really? I thought everyone snorted these to "get off". Snorted one OC 20 and feel totally baseline...wtf? I guess I was just curious what someone with a similar tolerance to mine, did to get off on these ;)
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As I mentioned before I snort two at a time. That's enough to give me a wonderful time, but not enough for the nausea to kick in. I suffered the vomits this morning for doing an 80 last night.
 
Most here seem to recommend approximately 20 mg for opioidnaive's for IR- oxycodone.
To get the same effect from SR-oxycodone (oxycontin), how much larger dose should be taken, in comparison with the dose of IR-oxy?

Im after a longlasting high which will last a full evening and night,that's why i want to preserve the SR.
 
Opiatesrarely said:
I fucking love this thread.
A 30mg OC might make you a little nauseous for the first time, but your blood plasma concentration shouldn't be too high. If you feel nauseous, lie down, but if you still feel nauseous, lie on your side with your bottom arm under your head and your top leg folded and your kneww pushed forward-out in case you throw up so you don't choke on puke, and all the puke goes down, but I doubt that will happen.
What does eveyone else think about my opioid-naive first timer advice for a quality high?
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Remove coating, crush her up, make 3 lines of similiar size.(if you .00mg scales you can make them like completely equal) Snort 2, wait 30mins and redose or save for tomarrow. The first strong opiate high is the best youll have euphoria wise so have fun.
 
Oxycontin Drug Interactions (Enzyme)

Recent studies show that certain drugs taken together with oxycodone (PERCODAN, TYLOX, OXYCONTIN) can dramatically affect the response to the widely used painkiller, resulting in problems such as excessive sedation, slowed breathing or, potentially, decreased painkilling effects of oxycodone.

How do these drugs interact, exactly? The use of other drugs with oxycodone can cause the levels of oxycodone in the blood to either increase or decrease.
This happens because oxycodone, an Opioid drug, is metabolized mainly in the liver by the enzyme CYP3A4. This enzyme is commonly inhibited by other drugs, and when drugs that inhibit CYP3A4 are taken with oxycodone, the blood levels of oxycodone may increase substantially.

A recent report from Finland found that one CYP3A4 inhibitor, voriconazole (VFEND), produced almost a four-fold increase in the blood levels of oxycodone. (For a more complete list of drugs that inhibit CYP3A4 and thus are likely to increase the risk of oxycodone toxicity, see Table 1. Because the extent of CYP3A4 inhibition by the various drugs in the list in Table 1 varies, the magnitude of the interactions with oxycodone may vary depending on which drug is used as well as the dose and duration of the drug.) On the other hand, some drugs can increase the activity of CYP3A4, which would markedly reduce blood levels of oxycodone. Such lowering the blood levels of oxycodone lowers the painkilling effects of the drug.

Another recent study from Finland found a dramatic reduction in oxycodone blood levels when people were given the "enyzyme inducer" TB drug. rifampin (RIFADIN, RIMACTANE) concurrently. Rifampin is one of the most potent medications for increasing CYP3A4 activity.

Other enzyme inducers are also likely to reduce oxycodone blood levels by speeding up its elimination, but the effect of these medications on oxycodone may be less than with rifampin. (For a more complete list of drugs that increase CYP3A4 activity and thus are likely to decrease oxycodone levels, see Table 2.) If you are taking Oxycodone with one or more of the drugs listed in tables 1 and/or 2, keep in mind that drug interactions may increase oxycodone toxicity or reduce oxycodone's analgesic effects
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Other Opioid Analgesics
NSFW:
Other opioids – metabolized by CYP3A4. Alfentanil (ALFENTA), fentanyl (SUBLIMAZE) and sufentanil (SUFENTA) are metabolized by CYP3A4 and these drugs are likely to interact with the CYP3A4 inhibitors and inducers in much the same way as oxycodone. Methadone is partially metabolized by CYP3A4 and may also interact with CYP3A4 inhibitors and inducers. Morphine. Morphine is not metabolized by CYP3A4 or other CYP450 enzymes, so it is unlikely to interact with CYP3A4 inhibitors, leading to higher blood levels. Nonetheless, its effect can be reduced by the "enzyme inducers" listed above, because they increase morphine metabolism, leading to lower blood levels.


Table 1

Drugs That May Increase Blood Levels and Effect

Amiodarone (CORDARONE, PACERONE)
Amprenavir (AGENERASE)
Aprepitant (EMEND)
Atazanavir (REYATAZ)
Carithromycin (BIAXIN)
Cyclosporine (NEORAL, SANDIMMUNE)
Darunavir (PREZISTA)
Delavirdine (RESCRIPTOR)
Diltiazem (CARDIZEM CD, CARDIZEM, DILACOR XR, TIAZAC)
Erythromycin (E-MYCIN, EES, ERYTHROCIN)
Fluconazole (DIFLUCAN)
Fluvoxamine (LUVOX)
Imatinib (GLEEVEC)
Indinavir (CRIXIVAN)
Itraconazole (SPORANOX)
Ketoconazole (NIZORAL)
Posaconazole (NOXAFIL)
Quinupristin (SYNERCID)
Ritonavir (KALETRA, NORVIR)
Tamoxifen (NOLVADEX)
Telithromycin (KETEK)
Verapamil (CALAN SR, CALAN, COVERA-HS, ISOPTIN SR, ISOPTIN, VERELAN)
Voriconazole (VFEND)

Table 2

Drugs That May Decrease Blood Levels and Effects

Carbamazepine (CARBATROl, TEGRETOl)
Efavirenz (ISUSTIVA)
Nakillin (NAllPEN, UNIPEN)
Nevirapine (VIRAMUNE)
Oxcarbazepine (TRllEPTAL)
Phenobarbital (LUMINAL, SOLOFTEN)
Phenytoin (DILANTIN)
Primidone (MYSOLlNE)
Rifabutin (MYCOBUTIN)
Rifapentine (PRIFTIN)
St. John's Wort


Thought this info would be useful in the Mega Thread
 
This thread is the best thing since: "Dude, he told me you can snort these?" "Yeah I heard that shit too man, we should suck the coating off and crush one of these bitches".......................
 
when tolerance develops what is usually the amount that needs to be increased to reach same effect?



[no drug testing questions. you've been here long enough to know this - 6/7]
 
Last edited by a moderator:
cire113 said:
when tolerance develops what is usually the amount that needs to be increased to reach same effect?



Also correct me if im wrong Oxycodone cannot be detected in standard opiate screening.......
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NO DRUG TESTING QUESTIONS read the rules
 
i used OC 20s and 40s pretty regularly 8 months ago because a family member had a prescription to them, but she doesnt anymore. she gets norco. i havent had any oxy in the last 8 months and was wondering how to get my own....
 
OxyContin - First Timer Questions

Hey guys. I was hoping I could get your thoughts on the best way to enjoy OxyContin. I shot dope for years (years ago), but I really never experimented with Oxys so I am retarded when it comes to dealing with time-release pills. In fact, the whole time-release thing always makes me really nervous. So I have just a couple questions:

1. Right now I have basically no opiate tolerance. What would be a good starting dose?

2. What's the best way to prepare the pill for oral administration? Just crush and swallow, right?

3. With snorting it, isn't there some concern about wax going up your nose? Or are you able to scrape that off first?

4. Which ROA do you prefer, oral or intranasal?

Thanks, I look forward to your sage advice! :)
 
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