txchick007
Bluelighter
Well...I've waited about an hour after snorting the first OC20. Time for the second. Crazy how high my tolerance must be (or maybe not).
what are some home remedies for overcoming withdrawal? trying to stop but its really killing me.. ive never gone threw withdrawal before (i didnt even think I used alot (30mgs a day) but i had to call out a second day at work for flu-like symptoms..
maybe i have the flu? or maybe its withdrawal...
Well...I've waited about an hour after snorting the first OC20. Time for the second. Crazy how high my tolerance must be (or maybe not).
Really? I thought everyone snorted these to "get off". Snorted one OC 20 and feel totally baseline...wtf? I guess I was just curious what someone with a similar tolerance to mine, did to get off on these![]()
I fucking love this thread.
A 30mg OC might make you a little nauseous for the first time, but your blood plasma concentration shouldn't be too high. If you feel nauseous, lie down, but if you still feel nauseous, lie on your side with your bottom arm under your head and your top leg folded and your kneww pushed forward-out in case you throw up so you don't choke on puke, and all the puke goes down, but I doubt that will happen.
What does eveyone else think about my opioid-naive first timer advice for a quality high?
Recent studies show that certain drugs taken together with oxycodone (PERCODAN, TYLOX, OXYCONTIN) can dramatically affect the response to the widely used painkiller, resulting in problems such as excessive sedation, slowed breathing or, potentially, decreased painkilling effects of oxycodone.
How do these drugs interact, exactly? The use of other drugs with oxycodone can cause the levels of oxycodone in the blood to either increase or decrease.
This happens because oxycodone, an Opioid drug, is metabolized mainly in the liver by the enzyme CYP3A4. This enzyme is commonly inhibited by other drugs, and when drugs that inhibit CYP3A4 are taken with oxycodone, the blood levels of oxycodone may increase substantially.
A recent report from Finland found that one CYP3A4 inhibitor, voriconazole (VFEND), produced almost a four-fold increase in the blood levels of oxycodone. (For a more complete list of drugs that inhibit CYP3A4 and thus are likely to increase the risk of oxycodone toxicity, see Table 1. Because the extent of CYP3A4 inhibition by the various drugs in the list in Table 1 varies, the magnitude of the interactions with oxycodone may vary depending on which drug is used as well as the dose and duration of the drug.) On the other hand, some drugs can increase the activity of CYP3A4, which would markedly reduce blood levels of oxycodone. Such lowering the blood levels of oxycodone lowers the painkilling effects of the drug.
Another recent study from Finland found a dramatic reduction in oxycodone blood levels when people were given the "enyzyme inducer" TB drug. rifampin (RIFADIN, RIMACTANE) concurrently. Rifampin is one of the most potent medications for increasing CYP3A4 activity.
Other enzyme inducers are also likely to reduce oxycodone blood levels by speeding up its elimination, but the effect of these medications on oxycodone may be less than with rifampin. (For a more complete list of drugs that increase CYP3A4 activity and thus are likely to decrease oxycodone levels, see Table 2.) If you are taking Oxycodone with one or more of the drugs listed in tables 1 and/or 2, keep in mind that drug interactions may increase oxycodone toxicity or reduce oxycodone's analgesic effects
when tolerance develops what is usually the amount that needs to be increased to reach same effect?
Also correct me if im wrong Oxycodone cannot be detected in standard opiate screening.......
NO DRUG TESTING QUESTIONS read the rules