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Opioids **The Oxycodone Mega Thread.** - Can't find your thread? Its in here.

^
always flush your nose with some water after snorting

prevents unnecesary damage and whatever your snorting will hit you harder
 
^Always do, thanks for the tip tho. But some people don't flush and that can cause a drop in strength, tho probably only very slightly.

Ahhhhh it's actually almost time to "flush" my nose again then hit another line. loves it.
 
Also depending on how much the person snorts , they may snort a line thats too big and thus all the powder doesnt cover the mucous membranes and just either sits on top of the powder or flys down the back of the throat and sometimes even into the lungs , which is why some people recommend using both nasal passages

but still these people that assume that the bigger the line you can snort the cooler you are or some shit , NEG it makes you look like a fucking idiot ... you nose can only absorb the oxy that is currently lining the nasal passage not the oxy that lies on top of the powder already coating the lining ..

which is why some people negate the ability of nasal bioavailability.

as long as you dont over pack the nasal passage when snorting that whole 17% loss wont be a problem .. its going to end up in the stomach at some point or another where the rest will be absorbed . unless you blow your nose ... then you have to lick the kleenex.. :P
 
I understand what you are saying. You are saying, that sure nasal bioavalabilty is like 60%, but what happens to the other 40? Does it disappear? Does it stay in the nose? If it stays in the nose, why doesnt it just drip down your throat into your stomach?
 
JASS92 said:
This entire post is wrong. Morphine's Bioavailability is much higher intranasally than orally.

In response to this thread, I believe the reason has to do with reaching peak plasma levels via protein binding. Oxycodone does not avoid first pass metabolism anyway, its just that oral Oxycodone it is readily converted into its active metabolites before being transmitted throughout the blood. With insufflation you reach peak plasma levels faster, but protein binding is less efficient. Voila.
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Morphine IS NOT MORE bioavailable intranasally than orally , are you out of your mind or just talking out of your ass . There is not one person on this board who in their right mind would say snorting morphine sulfate works any greater than taking it orally , ive tried many forms of intranasal morphine and they ALL BLOW . the only thing that would POSSIBLY increase nasal bioavailability is Chitosan . If youve read the BA thread you would know that ... here it is right here as stated by Sonic .. who knows what the hell hes talking about ..

Morphine ~30% oral/rectal, insuffulated- 15-20%, Chitosan(a linear polysaccharide that helps absorb drugs better) has been shown to increase nasal bioavailability of morphine from around 10-20% to over 60%, SC-60%, protein binding 30-40%, half-life is 2-3 hours

So dont even begin to say that morphine is better nasal than oral ....
 
aeguy567 said:
When they say that the nasal BA is 60% they are saying that when snorted 60% of the drug absorbs through the mucus membranes, the other 40% that isn't absorbed can then "drip" down into your stomach and be absorbed there, well it'd be more like 30ish% because not all of the shite you snort that doesn't get absorbed is going to make it to your stomach.
Click to expand...

No, that is not right.

With your logic, if somethings oral BA was 80%, that means 80% would get absorbed in the stomache/intestines, but where would the other 20% go? Nowhere, because 100% of it was absorbed, but only 80% is active. Same thing with snorting. If somethings nasal BA is 60%, that doesnt mean only 60% gets absorbed. 100% of it gets absorbed, but only 60% is active. The other 40% does not drip down to the stomach.

I think you have the idea of what BA is wrong. Read this:

Bioavailability refers to the difference between the amount of a substance, such as a drug, herb, or chemical, to which a person is exposed and the actual dose of the substance the body receives.
Click to expand...

That means, if you take 100mg of substance-x, and its oral BA is 80%, then 80mg will be the actual amount of the drug that becomes active. Same thing with snorting. If you snort 100mg of whatever, and its intranasal BA is 15%, than only 15mg of it will become active, even though 100% of it was absorbed.
 
ive been poppin tramadol all day today so my question is would i be alright if i popped an oc 20mg or even 40 mg?
 
How do you expect us to answer that question with the limited information you have given us?

How much tramadol? How much OC can you handle when not on tramadol? What is your tolerance to both drugs?
 
Id say no. Youre already on a dangerously high dose of tramadol. Just save the OC for when you come down. Youll get 2 highs that way, instead of one that could possibly end up being your last.

Ok, that last part was a little excessive. You probably wont die, but you could easily OD and have to go to the ER, which in turn could kill you, so...yeah. Save it for later.
 
Be careful with taking that much Tramadol it can be dangerous at levels above 400mg, especially at one time.
 
Yeah, hes definitely riding high in the seizure threshold. You (second650) really need to be careful how much you are taking. Your tolerance seems low enough, so why not try taking a little bit less next time, preferably below 400 - 450mg.
 
Or if you actually need that much Tramadol to get off then why not switch over to a different, probably stronger, opiate? I mean I'm not advocating you creating a nice addiction for yourself but if you are going to do opiates then why not use one that won't cause seizures at high doses, and one that you wouldn't have to take such a high dose of to get off. But then again by taking a stronger opiate you're just calling on different types of health risks to evolve. But if you're set on doing it then why not try and do it as safe as possible? JMO
 
Say one needs 200mg Tramadol to get a nice high. No opiate tolerance. Would scratching, snorting half and eating half of a 20mg oxy be too much?
 
i started yesterday off by taking 225 mg tramadol and then i spaced the doses out every 2-3 hrs. i wouldnt take 800 mg at once. today is a different story. i snorted 20 mg oxy this mornin but to my surpise its been an hour and i hardly feel anything! what am i doing wrong? i have 6 more 20's so what are youre suggestions?
 
Try a little more than 20mg. Obviously it isnt enough. Try 30mg, and if thats not enough, 35mg, and so on in 5mg increases until you get where you want.

Are you preparing the pill properly? Removing the outer coating? Are they name brand or generic? Remember what I said before about information? The more, the better.
 
its a pink pill marked oc on one side 20 on other. i didnt take the coating off tho. damnit! i messed up!
 
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