The Old and Overgrown Methylone Thread (11-2002 to 2-2007)

[djfriendly]

I've been searching for this answer but can come up with nothing conclusive. What is the relative strength of methylone's agonist properties (i.e. compared to MDMA). Not a lot of research done on methylone.

MDMA is an antagonist (of course) and also an agonist of HT1 and HT2 (and also D receptors?). It is also a partial/weak agonist of acetylcholine muscarinic receptors. One theory of MDMA neurotoxicity has something to do with the combination of the antagonist/agonist properties.

Shulgin, et al performed the study you're looking for about 8 years ago. I have posted the study abstract here within the last month or less, try UTFSE constraining to my username and "methylone" and you'll have what you're seeking. However, the study only looked at 5-HT and catecholamine sites AFAIK.

 

[Xorkoth]

i have heard Xorkoth or Ximot say that they can get off on as little as 50mg, i have tried this but only got threshold effects if that 200mg was where i found the sweet spot

That definitely wasn't me... I require 200mg or so. Actually I prefer to take it rectally at 150 to 200mg.

 

[Helios.]

Gram for gram, methylone is in my experience about 40% as active as MDMA.

At dosages above 500mg nervousness, shakiness, find hand tremor, pressurized thought patters, and mental thought racing may be experienced.

 

[Jabberwocky]

That definitely wasn't me... I require 200mg or so. Actually I prefer to take it rectally at 150 to 200mg.

In your experience (and anyone elses) is it shorter if taken rectally? I've heard talk of quicker come-ups, more intense peaks, etc, which lead me to believe it might be shorter overall rectally. Hope my conjecture is wrong.

Methylone would be one chemical I would not look to shorten the duration.

 

[Jabberwocky]

Point1: I am curious about the fact that some people claim that anything below 175mg is not enough to get the 'methylone experience.'

I am wondering how to reconcile this data point with the close mechanism of action to MDMA and the fact that this property is lacking from MDMA. A dosage level of 50mg of MDMA, for instance, will produce subjective effects comparable to (but lacking in intensity) to 120mg MDMA.

I am guessing that below 175mg (an arbitrary line, it could very well be 125mg for you) of m1 the chemical is largely engaged with receptor affinity that is not as pleasing as dosages of 175mg+ (i.e. there is a 'saturation level' reached and eventually the chemical starts activating more pleasurable receptors. Or maybe it is a certain combination of D and HT receptors that is pleasurable?).

Well, my biochemistry is very well likely off, but my point I take it is clear enough. I am guessing with MDMA this low dosage specificity in regards to receptor affinity is lacking and its activation of D and HT receptors is more uniform across its dose response curve.

Point2: Could certain receptors gain a tolerance quicker for m1 than other receptors? For instance, could HT receptors become tolerant of m1 quicker than D receptors (and concurrently could HT be released/depleted quicker than D). Could this provide evidence for the lack of euphoria present in redosing m1 (but the notable stimulant properties)?

 

[Helios.]

It's not about made up names for purported chemical receptors.
It's about the physical organic chemical structure of the compound.

 

[BreakingSet]

Point1: I am curious about the fact that some people claim that anything below 175mg is not enough to get the 'methylone experience.'

I am wondering how to reconcile this data point with the close mechanism of action to MDMA and the fact that this property is lacking from MDMA. A dosage level of 50mg of MDMA, for instance, will produce subjective effects comparable to (but lacking in intensity) to 120mg MDMA.

I believe Ximot made the claim that 50mg of M1 is active. I agree. I have found it very rewarding to take 50-70mg and have a couple of beers (I do not drink a lot so 3 beers is usually the max in an entire evening). 50mg M1 most definitely has an effect, but it is very mild; so mild in fact that at museum levels, if there is too much going on around you, you may miss it.

I'm no chemist so most of your question are 1) not aimed at the likes of me which is good because 2) they're shot well over my head.

 

[Jamshyd]

I think this goes back to what shulgin called "window" experiences with MDMA and what the raver guy who introduced me to E called a "peak".

The MDMA high is consistent, despite varrying intensity with different doses, but after a certain dose line, something "opens" and it seems like a second experience takes over on top of the high itself. Unlike peak experiences with psychedelics, this "window" thing seems to be certain as long as you take enough.

Perhaps this is the same for Methylone after the 175mg mark?

 

[colors]

first try @ 125mg oral ... no noticeable effects.

second try @ 215mg oral
-t+2hr to peak
-better mood, empathetic drive to interaction, comfortable energy (no pulse bs or shakes), positive dreamy headspace, easy to function easy to integrate.
-t+4hr gentle comedown

third try @ 235mg oral on empty stomach
-fast onset (30min), incredible comeup for t+ 1hr, very euphoric
-felt the 'love' very strongly
-socially opened me up, not witty and quick just saying w/e on my mind (cliche mdma kind of thing i guess)
-jaw clench at t+4hr, couldn't sleep w/o benzo

clean as a whistle

 

[Xorkoth]

In your experience (and anyone elses) is it shorter if taken rectally? I've heard talk of quicker come-ups, more intense peaks, etc, which lead me to believe it might be shorter overall rectally. Hope my conjecture is wrong.

Methylone would be one chemical I would not look to shorten the duration.

I didn't notice it to be shorter, although with such a short duration, a small percentage difference may be hard to notice. If anything, it's a small bit shorter. But like I said, I didn't notice it to be shorter, although the comeup is definitely faster. The subjective experience was pretty much the same as an oral dose, except with less material required.

 

[melange]

ok bluelighters - I am on 225mg tonite


defiantly dulled - I think it is because that I have used to much this month(well december anyways - over 2 grams)

maybe its the neurontin i take everyday? I dont think it is


but I won't go on a silly rant like last time, which I again apologize for


it is a subtle euphoria, but still pleasant - prob. still tolerance


I do agree with ximot tho, that there is a bit of addiction potential, maybe not for everyone tho.

 

[Ximot]

I haven't used methylone in about a month now, though I most likely will within the next 2 weeks or so. I have kind of fallen out of love with it as it changes character after excessive regular use (2 years, 60+ full-blown experiences and then some, I didn't count). But I can still feel very low doses of it (even under 50mg, perhaps even 25mg). It's not that tolerance goes up (in the sense that more is required for similar effects). In fact, the more I've used it, the more I've gotten to "know" it, its essence, its effects, what it does, how it feels.

 

[melange]

ok, on it again tonite, bout same dose


deff abusing it at this point


my fav thing to do while on it, is to have a type of "music therapy"


listening to my favorite songs, loving the music euphoria it brings

 

[Xorkoth]

^^ That's what tends to happen with me when I have methylone. Consequently, I only grab any now when I can't refuse the deal, and in small amounts. Although I haven't noticed any lasting negative effects from repeated use, unlike MDMA, it's never a good idea to do a drug 3 nights in a row!

 

[melange]

^haha

you are quite right

 

[illusion25]

i tried 185 mg for the first time on this chemical.

i was disapponted.
i felt euphoric for a while. similar to mdma but more mild. after a couple of hours i was tweaked out and crashed. felt like shit and was depressed. i dont usually enjoy uppers. i get to anxxious and worried.

but i will give it a tr at a higher dose hoping to get a better high.
i will have to have some benzos for the comedown though. I hated the comedown. equally as horrible as mdma comedown. depressing.

 

[melange]

question


will a small dose of 2ce heighten the effects of methylone at all?



for instance small doses of 2ce are fairly euphoric to me


combined with methylone do you think that would be a bad idea? or should i just not bother?

 

[PhiliusBoro]

took 175mg tonight, first time, although I think I;ve had bzp/methylone pills in the past (doves), certainly has a similat feeling.

Very impressed, very gradual come-up, the warmth was there, and just felt totally contented.

I haven't done mdma in a couple of years, its definitely not as intense, but is very very nice.

recommended.

 

[Jabberwocky]

First real trial with methylone last night. 103mg administered rectally followed by 11mg of 2CB administered rectally (at T+2.5hours).

103mg of methylone was QUITE enough for a full +++.

I was in a state of ecstasy for 3+ hours. Could not stop moving, leaping and dancing around and rolling across the carpet. I was pouring sweat. It felt so good to release that energy. Then the 2CB visuals came!

Strange thing, but there is some residual stimulation still (T+20 hours). My tongue won't stop moving across my teeth. I feel physically drained today but very content.

They both hit/were peaking almost exactly 15 minutes after administering them (in solution). I don't think I will ever take a 2C-x any other way than rectally. I know this is a methylone thread, but I'd add that 2CB was almost completely devoid of any deep cognitive states for me. I had psychedelic thoughts of being a snake and a bird, but there was no challenging material that has already been felt on 2CE (which has yet to be brought to a FULL +++). 2CB was just a really fun ride (which feels amazing, bodywise).

Methylone however allowed me to open up to and accept something that has been bothering me on and off for the past few months.

Love!

 

[Ximot]

My tongue won't stop moving across my teeth.

Haha, welcome to the tongue-rolling club. I'm the vice-president. %) Though it only happens to me on the day I use M1 - next day it's usually gone.

I wonder to what extent the M1 may have affected the 2CB and made it less cognitive, adding imagery to make up for that. May also have positively affected the body high of the 2CB to some extent.