I for one have suffered physical withdrawals from tramadol.... I didn't think it would really happen, I have been taking them for about 8 months. and I brushed it off, but the first time I ran out, it was about a day and a half later, I would start to get this weird tickle in my throat that wouldn't go away no matter how much water I drank. and my legs particularly my thigh muscles, get this tight bunched up feeling in them making me have to flex them every 5 seconds it's really hard to describe it makes you want to jump right out of your skin and IMpossible to sleep. I can only guess this is RLS, as well my nose would run and I would be Super Fatigued and out it. Feeling like shit, nauseous with cold sweats. At First I wondered if maybe I was really just getting sick, I went to the pharmacy and got a little bit of codiene in a codiene cough syrup and it immediately took all symptoms away.. thats when I knew it was my first Physical withdrawal. and any time I run out of tramadol about a day later these symptoms come back Every Single Time. So yes there is significant physical withdrawal from tramadol it is the only Physical withdrawals I've ever had...