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  • BDD Moderators: Keif’ Richards | negrogesic

The Official Tramadol Discussion Thread

Tramadol possesses agonist actions at the μ-opioid receptor and affects reuptake at the noradrenergic and serotonergic systems.[3][4][5] Tramadol is a compound with mild and delayed μ-agonist activity.

Tramadol is a synthetic stripped-down piperidine-analog of the phenantherane alkaloid Codeine and, as such, is an Opioid and also a pro-drug (Codeine is metabolized to Morphine, Tramadol is converted to M-1 aka O-desmethyltramadol). Opioids are chemical compounds which act upon one or more of the human opiate receptors (the euphoria, addictive nature and respiratory depression are mainly caused by the Mu(μ) 1 and 2 receptor. The opioid agonistic effect of Tramadol and its major metabolite(s) are almost exclusively mediated by the substance's action at the μ-receptor. This characteristic distinguishes Tramadol from many other substances (including Morphine) of the opioid drug class, which generally do not possess Tramadol's degree of subtype selectivity.
 
Tramadol possesses agonist actions at the μ-opioid receptor and affects reuptake at the noradrenergic and serotonergic systems.[3][4][5] Tramadol is a compound with mild and delayed μ-agonist activity.

Tramadol is a synthetic stripped-down piperidine-analog of the phenantherane alkaloid Codeine and, as such, is an Opioid and also a pro-drug (Codeine is metabolized to Morphine, Tramadol is converted to M-1 aka O-desmethyltramadol). Opioids are chemical compounds which act upon one or more of the human opiate receptors (the euphoria, addictive nature and respiratory depression are mainly caused by the Mu(μ) 1 and 2 receptor. The opioid agonistic effect of Tramadol and its major metabolite(s) are almost exclusively mediated by the substance's action at the μ-receptor. This characteristic distinguishes Tramadol from many other substances (including Morphine) of the opioid drug class, which generally do not possess Tramadol's degree of subtype selectivity.

This is why I prefer taking trams orally rather than plugging (my usual preferred roa). Just seem to get more of the opiate feeling quicker along with the serotonergic feeling. It also helps if I space them out by about 45minutes to let the liver do it's thing converting it to o-desme.
 
tramadol is a drug. sold by drug dealers, for real.

I was nearly blacked out drunk the last time my tramadol pharmacy called me. It was in Late November. I told the lady on the telephone I loved her drugs, that they got me high as shit, and that I couldn't buy any more until I robbed someone in late January. I was just being a jackass to the telephone sales-woman, because I actually meant I wouldn't buy any more until I got my tax-return in late January, but she would call me three to four times everyday, so I told her that absurd story to get her to stop calling. But I did want her to call when I had money, because she could offer a discount over the online-portion of her store.

...She called me this morning, while I stoned out of my mind and coming down from a psychedelic as well, and asked, "(Lazydullard), do you remember you said you'd buy more in January...?"

I didn't even hide my intoxication... And told her to call me later. Because I needed a little more time. And she agreed and said okay.

So... If you're thinking about getting into tramadol, watch out.. They really want your damn money.

I mean, if you gotta be addicted to something, tramadol is a good choice, yeah?
 
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their okay in a pinch

took 350 mg two hours ago and i feel okay. not like taking "real" opiates but better than nothing. shrug.
 
hmm, too add to some existing discussion, 3-4 inches in should be fine enough. I've made a syringe of tramadol before, it was as dark as canned evaporated milk almost. I drank it, but plugging would probably work. IV or IM like I was pondering would have been death or an abcesss, I think. It instantly clogged the wheel filter I tried to push it through. So yeah, I drank it.

Tramadol is cheap and plentiful enough that I just eat it. For other ROAs, I can say eating is better than snorting, regardless of dose and tolerance.
 
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