This is my experience insufflating the new Opana ER TRFs and it has worked very well for me.
The method I use is to grind the pills up:
1) Get a dremel tool - I find the dremel works MUCH better than electric screwdrivers due to the dremel's significantly faster rotation speed
(I use the 7300 MiniMite Cordless Dremel:
http://www.amazon.com/Dremel-7300-N...ref=sr_1_1?s=hi&ie=UTF8&qid=1335751454&sr=1-1
The aluminum oxide grinding stone tip worked very well and is included in the package. I got mine at Lowes and I'd bet you could also get it at home depot as well if you don't feel like waiting for shipping.)
2) Cut a small hole in side of an empty water bottle that MUST BE COMPLETELY DRY (like if you were making a bong out of it and were cutting a hole for the mother piece)
3) Cut the top off the water bottle (so it has a big enough opening to fit a dremel tool in)
4) Using needle nose pliers, hold the pill and put it through the small hole in the side of the water bottle
5) Put dremel tool in the water bottle and start grinding the pill - be sure you are using a dremel tip that will not fall apart and shed sand
6) Once you are done grinding, dump the powder out and enjoy.
It is also important not to directly grind the pill for too long or else the friction will cause too much heat and begin to make the pill melt/gel up rather than create a fine powder. The water bottle is important because otherwise the pill powder will fly everywhere. Also, I have found that by mixing in some baking soda with the ground pills (~1/3 to 1/2 as much baking soda as you have ground pills) helps keeping the powder from clumping and also seems to help preventing the powder gelling up as much in your nose.
Using this method works just as well as snorting the old yellow stop signs. I am not sure if it is due to my currently low tolerance, using baking soda or what, but snorting these actually hits me harder and lasts much longer than the old formula, anyone else notice this?