footscrazy
Bluelight Crew
Junkie_Scumbag I moved your post to the methadone, buprenorphine and other opioid pharmacotherapies thread as it concerns maintenance rather than smack.
Please need to know at short notice how to inject grey morphine MS Contin pills, described by aussies usually as grey nurses, or grays,
Done it before once (years ago) but want to know other people techniques on this. cause I just added 3ml cold water to 1 x 100mg pill after grey coating was off but felt like i lost about 40%, still got very decent pins needles rush with some gel but I could still suck up 2ml and bam.
I am sure some of you aussie's out their might have some better experience/techniques????
No not at all hecticus, a point of good gear with no tolerance will give mad rush and nod when IV.
Does fentanyl or hydromorphone have a longer half life
I believe that liver metabolizes codeine into hydromorphone and something else that i can't remember from the top of my head.
Quite possibly there are enzymes at work or that are inhibited when opium is consumed which in increases the bioavailability of the various opiates.
Codeine is an opium alkaloid, found in plants of the papaver, primarily P. somniferum1. Structurally, it is very similar to morphine with the only difference being a methoxy moiety (R-O-CH3) attached at the 3 position on the molecule. When codeine is consumed by humans a portion of the dose is metabolized into morphine, which is carried out by the isoenzyme CYP2D62. Codeine is also metabolized into codeine-6-glucuronide via conjugation with glucuronic acid and n-demethylated to codeine. Some studies suggest that codeine-6-glucuronide may be responsible for part of the analgesia codeine provides3.
The effects of codeine are very similar to morphine, though less potent; only around 10% of the codeine is converted into morphine, and around 10% of the Caucasian population is deficient in the isoenzyme that is necessary for this conversion to take place4. Poor CYP2D6 metabolizers experience decreased levels of analgesia and euphoria compared to normal and extensive metabolizers. Anecdotal reports suggest that some users reach a 'ceiling dose' with codeine, usually around 400-600mg, and increasing the dose past this point does not increase euphoria or analgesia but rather leads to increased side effects. On the other hand, there are reports from users with a tolerance dosing as high as 2000mg or more.