RCs The Methiopropamine N-methyl-1-(thiophen-2-yl)propan-2-amine (MPA) Megathread V2

[Machete]

I agree with Machete about the possible MAOI interactions, but i'd like a link to where he is getting he data regarding how MPA is processed by the brain and in particular the references made to "Key neurochemicals" being affected by MPA, not because i am in any way doubting his post or the facts in it but i would like to read a proper scientific paper on the neurological effects of MPA.

MAOIs are weird drugs, i am astounded they are still being used what with TCAs and then SSRIs but i guess there is reasons for them being prescribed that i have missed. Pretty much every drug you take when on MAOIs is a bit of a risk but given that Amphetamines, MDMA, Dextroamphetamine & Methamphetamine are all contra indicated i would proceed with great caution keeping an eye out for symptoms of Seretonin Syndrome, Hypertensive crisis and Physchosis which are the three main problems arising from MAOI interactions. Given you have been using them both for 11 days indicates that it might not be a problem but I personally would try and space it out so you aren't dosing MPA at the same time as taking MAOIs so there is time for them both to get processed separately to some extent.

If you don't mind, may i ask what MAOI you are taking just out of curiosity.

S

Methiopropamine's main active metabolite, the demethylated thiopropamine, has the 2-aminopropane group which would probably mean that its an MAOI. I don't know for certain that it is an MAOI (who does?) but it seems likely that it is and other people have sometimes said the same thing. So by "key neurochemicals" I just meant the monoamines whose levels would be indirectly affected by an MAOI. From the perspective of most of us on here, the majority of the neurochems we actually care about are monoamines so I didn't go into specifics.

I wish I had a paper to offer you, mate, I really do. Unfortunately all I've got is the reasonable conjecture of a handful of people!

Also, anecdotally, the haziness of MPA reminds me of when I did a whole bunch of nutmeg one summer (the myristicin in nutmeg, as you may well know, is an MAOI)

 

[closeyoureyes]

Hi guys. Sorry if this will be a dumb question, I'm new here, but can somebody tell me if it would be ok to do an 5-APB and MPA combo? I'm also wondering how would it feel mixed with LSD or other classic psychedelic stuff? Maybe it would give some courage and energy for the trip?

 

[Pasht]

It seems that Methiopropamine is gaining popularity again, which is fine, considering the shitty Ethylphenidate batches being on sale in Europe now. I used it about a year ago, and remember that it was good, clean stim with no noticeable comedown. Decided using it as functional stimulant. What surprises me is that rectal route seems to be being most effective in many persons opinion. Surely it's economical, but are the effects qualitatively different from sniffing/bombing MPA?
My second concern is the smell of the stuff, when I received it from a reputable vendor, it had that distinct 'rotten eggs' smell; I read elsewhere that it's sign of degradation due to inept storing, in that case, what kind smell should good quality MPA have, or should it be odorless? Thanks.

 

[Samuelg]

Methiopropamine's main active metabolite, the demethylated thiopropamine, has the 2-aminopropane group which would probably mean that its an MAOI. I don't know for certain that it is an MAOI (who does?) but it seems likely that it is and other people have sometimes said the same thing. So by "key neurochemicals" I just meant the monoamines whose levels would be indirectly affected by an MAOI. From the perspective of most of us on here, the majority of the neurochems we actually care about are monoamines so I didn't go into specifics.

I wish I had a paper to offer you, mate, I really do. Unfortunately all I've got is the reasonable conjecture of a handful of people!

Also, anecdotally, the haziness of MPA reminds me of when I did a whole bunch of nutmeg one summer (the myristicin in nutmeg, as you may well know, is an MAOI)

Sorry if i came across a bit aggressive, reading it back what i was trying to ask for was a paper/reason you think it is That seems a likely outcome of the 2-aminopropane that i hadn't really considered.

I think if you did a poll across bluelight of how many people have gotten bored and eaten all the nutmeg in their house at some point in their life the results would be pretty definitive, its like a rite of passage. My main memory of it was how disgusting large quantities of nutmeg are even in milk... *shudder* followed by feeling a bit wonky for 2 days. Not something i will be repeating not least because i know far better about its hepatotoxic qualities. Some people love it though so i guess it might be a matter of preference.

It seems that Methiopropamine is gaining popularity again, which is fine, considering the shitty Ethylphenidate batches being on sale in Europe now. I used it about a year ago, and remember that it was good, clean stim with no noticeable comedown. Decided using it as functional stimulant. What surprises me is that rectal route seems to be being most effective in many persons opinion. Surely it's economical, but are the effects qualitatively different from sniffing/bombing MPA?
My second concern is the smell of the stuff, when I received it from a reputable vendor, it had that distinct 'rotten eggs' smell; I read elsewhere that it's sign of degradation due to inept storing, in that case, what kind smell should good quality MPA have, or should it be odorless? Thanks.

I've never had MPA with any discernible smell from either of the two vendors I've used, both of which i've been assured are reputable by a few people, whether that means it is or not who knows. I guess it would be due to the sulphur molecule being made more prominent, what storage conditions would amount to that I'm unsure. How dusty is it, or how easy does it cut up into lines ? I'm guessing moisture, uv exposure or manufacturing error would lead to that. It may just be a variable between different bulk suppliers as to how much smell there is. Pretty much all the RC powders i've tried have smelt mostly just vaguely chemically.

 

[Pasht]

I've had it as very clumpy powder, hard to cut into lines, so I guess you're right. Maybe MPA is highly hygroscopic as well.
I've only been sniffing MPA, but plan to use other routes soon. Glanced through the topic yesterday and made me some notes regarding the administration routes, correct me if i'm wrong?

-nasal: most speedy, quickest onset, short duration
-oral: average stimulation, slow onset, long duration
-rectal: mild stimulation, onset on par with sniffing, a bit euphoric (?), long duration

Some users have even commented that it seems like another drug, depending how you take it, any comments? I think i'll experiment a bit, but will avoid IV'ing and IM'ing.

Also, I would like to know if the vasoconstriction intensity is route-dependent.

 

[lynx2051]

If you rub mpa on your fingers it has a very greasy feel to it.

 

[Samuelg]

I've had it as very clumpy powder, hard to cut into lines, so I guess you're right. Maybe MPA is highly hygroscopic as well.
I've only been sniffing MPA, but plan to use other routes soon. Glanced through the topic yesterday and made me some notes regarding the administration routes, correct me if i'm wrong?

-nasal: most speedy, quickest onset, short duration
-oral: average stimulation, slow onset, long duration
-rectal: mild stimulation, onset on par with sniffing, a bit euphoric (?), long duration

Some users have even commented that it seems like another drug, depending how you take it, any comments? I think i'll experiment a bit, but will avoid IV'ing and IM'ing.

Also, I would like to know if the vasoconstriction intensity is route-dependent.

Rectal is a pretty efficient way of administrating MPA i've found, as have others on here. That being said i usually go for insufflating for the sake of ease. Vasoconstriction is part of the MPA being absorbed so in general the more you feel the MPA the more vasoconstriction you'll find, i've never really found the vasoconstriction to be a problem except when IVing but even then it was just a matter of cold hands and feet. Obviously if you have any other conditions or medications that may interact and cause more of a problem but i think its more dose dependent than ROA dependent, unless anyone knows otherwise ?

I'd say, although i don't have a lot of experience with oral admin

-nasal: Quickest onset, more intense stimulation but still functional, average duration of 3-5 hours + after effects
-oral: Slower onset, average stimulations, longer lasting but more mellow.
-rectal: Quicker than oral, slower than nasal, vaguely euphoric in high doses, inconvenient but effective.

If you rub mpa on your fingers it has a very greasy feel to it.

One wonders if its greasy or just appears greasy because its such a fine powder creating a smoother surface than normal. I've tend to try and avoid getting it on my fingers it seems like the kind of powder that would leave tiny dusty marks on everything i touched for the next hour

 

[Mush1]

I have taken pretty substantial amounts of MPA with both sertraline (SSRI) and Dosulepin (TCA + Norepinephrine reuptake inhibitor) without any problems so i would say that there wouldn't be any reason it would cause an issue re: serotonin syndrome.

I should point out sertraline and dosulepin were not at the same time, TCAs and SSRIs like citalopram are best not mixed but you weren't going to anyway. Twas simply clarifying

Bad anecdotal news I'm afraid. May have been from the fact I'd been up for 36 hours, but I took my sertraline with a much smaller than normal (sorry to be unspecific) bump of MPDV and an hour later was in the emergency room.

ECG showed 120bpm, BP 140/88 (I'm normally 96/62) clonus, sweating, confusion and I had temporary paralysis of my right hand side. Putting it down to dehydration and lack of sleep, but it could have very well been serotonin syndrome.

Stay safe all.

 

[Samuelg]

Bad anecdotal news I'm afraid. May have been from the fact I'd been up for 36 hours, but I took my sertraline with a much smaller than normal (sorry to be unspecific) bump of MPDV and an hour later was in the emergency room.

ECG showed 120bpm, BP 140/88 (I'm normally 96/62) clonus, sweating, confusion and I had temporary paralysis of my right hand side. Putting it down to dehydration and lack of sleep, but it could have very well been serotonin syndrome.

Stay safe all.

ooof bad news, glad you are relatively alright. I have had limited experience with MDPV but always thought it to be a NDRI rather than having effects on seretonin. I suppose its the risks taken with undocumented chemicals. Well done on swallowing your pride and getting to hospital, better to have a few sideways glances from suspicious doctors than find yourself in real trouble. That being said recorded fatalities of RCs tends to put me off them somewhat so i never fancied MDPV, fingers crossed no one takes a gram of MPA at once and ruins the fun for us all

 

[Pasht]

How much MPA do I need when smoking off foil to get some kick?

 

[lynx2051]

Id say between 15 - 20mg just to be on the safe side. I've never smoked it though.

 

[closeyoureyes]

Me and my buddies got pretty drunk and experimented with MPA and some 5-APB but it mostly was MPA. After my first around 50mg line of MPA, few drinks and 50mg bomb of APB I completely lost self control and ended up doing I don't really know exactly how much but it was around 300 mg, maybe even a little bit more. Now I realise that it was extremely stupid thing to do because I had one of the worst handgovers the other day. My dick was the size of a peanut, jaw completely fucked up, I was sweating cat piss in my bed for seven hours without any signs of falling asleep, random pain in random spots and very alerting heartbeat. It was worse than speed hangover. But oh god oh god how amazing my night was. One of the greatest parties ever :D danced like crazy, there was not even a second of tiredness or lazyness.
It sinergized with alcohol perfectly and apb gave it even more euphoria. I actually woulve not needed any APB or more thant 150 mg of MPA,but it just took over me and took all my logical and careful side away, never before I thought that I could be such a drug fiend...Now i even feel a little bit embaressed for the way I looked and acted. I was completely blasted off, best feeling in the world for the whole night, that's pretty cool. However, I hope I will never loose control over myself like that ever again because the day after was just terrible. Worst feeling ever for the whole night. I guess that's just the price you have to pay.
If anyone is going to try mixing it with other drugs please be careful, at least don't loose control on your dosage because you will be sorry next day, I swear.

 

[Machete]

DO NOT SMOKE THIS STUFF

It'll produce toxic sulphur oxides when burnt and you'll die if you do it enough.

Edit: once again, I don't have any actual evidence for that claim but sulphur dioxide is definitely toxic and burning this stuff produces it. I've also heard stories of people getting pretty fucked up from vaping this shit.

 

[lynx2051]

Has anyone else had any mania symptoms while one MPA? Even when only taking your first 35mg oral dose. I suddenly got really depressed and couldn't stop crying and talking to myself then laughing suddenly. I self harmed by cutting my leg also. I've been feeling a bit low anyway this past month and not even seen any friends for about six weeks.

I don't think MPA directly caused what I did. I've felt like that when sober for the past two weeks but I didn't do anything like that. I have been having suicidal thoughts too. I'm also on 20mg citalopram which has been making me feel a bit forgetful and giving me mixed moods.

 

[foolsgold]

DO NOT SMOKE THIS STUFF

It'll produce toxic sulphur oxides when burnt and you'll die if you do it enough.

Edit: once again, I don't have any actual evidence for that claim but sulphur dioxide is definitely toxic and burning this stuff produces it. I've also heard stories of people getting pretty fucked up from vaping this shit.

maybe best following this advice but iv smoked up to maybe just over a gram of the stuff except for the house sticking to high heavens iv not had any problems instead its helped open up my lungs . also iv been talking with people me included saying how for some reason it just does not work these days , nothing not a thing i found this as well until say i had a smoke of mam2201 then it would kick it off .

wonder why this is

Has anyone else had any mania symptoms while one MPA? Even when only taking your first 35mg oral dose. I suddenly got really depressed and couldn't stop crying and talking to myself then laughing suddenly. I self harmed by cutting my leg also. I've been feeling a bit low anyway this past month and not even seen any friends for about six weeks.

I don't think MPA directly caused what I did. I've felt like that when sober for the past two weeks but I didn't do anything like that. I have been having suicidal thoughts too. I'm also on 20mg citalopram which has been making me feel a bit forgetful and giving me mixed moods.

im not the best to talk about abusing drugs but please lynx get to a doctors your a wreak waiting to happen iv been there just like this 2-dpmp and mdpv it does go but i had other things to take my mind away from it . and for the love of god do not take mdai if your this way out you will slit your wrist without thinking that shit is suicide in powder form

 

[THCified]

So what's a good plugged dose for this one? I thought about ~35mgs...

 

[foolsgold]

with the dodgy batches of late i think you could stick a full gram up your bum and get nothing till you mix it with some thing that you know works straight away

 

[Part Time Junkie]

how do you guys compare it to EPH? Also do they mix?

 

[Samuelg]

Has anyone else had any mania symptoms while one MPA? Even when only taking your first 35mg oral dose. I suddenly got really depressed and couldn't stop crying and talking to myself then laughing suddenly. I self harmed by cutting my leg also. I've been feeling a bit low anyway this past month and not even seen any friends for about six weeks.

I don't think MPA directly caused what I did. I've felt like that when sober for the past two weeks but I didn't do anything like that. I have been having suicidal thoughts too. I'm also on 20mg citalopram which has been making me feel a bit forgetful and giving me mixed moods.

I had a bit of a bout of physchosis style effects when i was taking it with benzos solidly for 2 weeks with very little sleep it was mostly just staring into the mirror and laughing then crying and deciding life was pretty pointless. I kicked myself out of it mostly by running out of benzos and getting some weed and having a break from MPA and benzos.

Sorry to hear you're having a shitty time i've been there before and its really grim i agree with foolsgold that you should go to the doctors you don't even need to mention the MPA unless you want to but either way they will try to help you out. You're in the UK right ? The GPs here are really friendly and will help you out despite RC use or anything, unlike the US where doctors seem to hate anyone who takes any kind of drugs.

Hope things pick up for you and stay safe

 

[foolsgold]

^^ nice one yer please look in to getting this sorted lynx . as for the doctors do not go to strensall one just out side of york bastards just fob you off with go to rehab and o do you mean mkat all fucking time make out that im drug seeking and have no interest in helping you at all . and they wonder why iv had a bad drug habit for 20 years and be section twice for trying to kill my self any wonder when the treat you like shit