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The Main 5-MAPB Thread

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Transform said:
Yes, cocaine is a reuptake inhibitor so will block some of the effects of 5-MAPB (or any other releasing agent).
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I don't understand. Why would a reuptake inhibitor block the effect of a releasing agent, instead of enhancing it?
 
Torresmo said:
I don't understand. Why would a reuptake inhibitor block the effect of a releasing agent, instead of enhancing it?
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Releasing agents burst vesicles, flooding the cell with serotonin, and reverse transport channels, causing serotonin in the cell to be pushed out into the synapse.

Reuptake inhibitors block transport channels, causing serotonin in the synapse to stay in the synapse. But because they block those channels, they also cause serotonin in the presynaptic cell to stay in the cell.

In practice, at low levels they're additive and at high levels they compete. Eg. Doctors will sometimes prescribe vyvanse with ritalin as a booster.
 
InterestingFACT said:
Releasing agents burst vesicles, flooding the cell with serotonin, and reverse transport channels, causing serotonin in the cell to be pushed out into the synapse.

Reuptake inhibitors block transport channels, causing serotonin in the synapse to stay in the synapse. But because they block those channels, they also cause serotonin in the presynaptic cell to stay in the cell.

In practice, at low levels they're additive and at high levels they compete. Eg. Doctors will sometimes prescribe vyvanse with ritalin as a booster.
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Thanks, I got it! I thought releasing agents simply increased the release of neurotransmitters out of the presynaptic cell to the synapse and I thought reuptake inhibitors somehow just stopped the transporters from taking the neurotransmitters back inside the cell (without blocking the channels).
Its always exciting to learn! :D
 
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Reuptake inhibitors block the transport proteins which allow releasing agents to get into the neuron and work their magic, as well as preventing the releasing agent from reversing the reuptake transporter to allow flooding of the synapse.

There are a few threads dedicated to the discussion of 6-APDB
 
I took ~50mg of 5-mapb this morning. It was a very positive experience. The music appreciation was unbelievable, and the euphoria was extremely controlled compared to AL-LAD/2c-b/4-aco-dmt. One thing I am curious about - I experienced no pupil dilation whatsoever. In fact they seemed smaller. Is this abnormal?

I did experience a bit of melancholy after the comedown. But I hadn't eaten in nearly 24 hours and I was tired, so that may have contributed to it. It has been nearly 12 hours after the dose and I am currently in very good spirits. With no noticable side effects.
 
50mg of 5-MAPB.HCl should at least be noticeable to anyone without much tolerance. It is almost twice as potent as MDMA.
 
My first trial with 5-MAPB was also at 50mg and I indeed found it noticeable, despite my general high tolerance for serotonin releasing agents.
 
^that seems too high for a first time.

Common wisdom around here--that my personal experience can back up--is that 5-mapb "feels" a lot stronger when you take it with a dopaminergic agent. Try taking 100mg with some adderall or some 2-fma.

For the record, my first time trying 5-mapb, at 30mg by itself, I felt very noticeable effects. A few of my friends, however, didn't notice much until they got closer to 80-90.
 
heerutosen said:
How would you compare 100mg 5-mapb to 150mg mdma? Besides lasting longer.
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Quite comparable, but its been so long since I had genuine mdma, and not methylone, but I like this alot better than methylone. a lot lovey doevey and music appreciation.

I think I am going to try a small micro LSD dose with a full 150mg next time and see how that goes, probably dosing 2 hours into the lsd
 
InterestingFACT said:
^that seems too high for a first time.

Common wisdom around here--that my personal experience can back up--is that 5-mapb "feels" a lot stronger when you take it with a dopaminergic agent. Try taking 100mg with some adderall or some 2-fma.

For the record, my first time trying 5-mapb, at 30mg by itself, I felt very noticeable effects. A few of my friends, however, didn't notice much until they got closer to 80-90.
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Most guys on the dutch forum dose 125mg and the ones with a higher mdma tolerance (175mg to 200mg in one go) Report needing 150mg or higher for full effects.
 
It's better mixed with 20-30 mg 2-fma or 4-fa. Requires less 5-MAPB and you get a nice dopamine rush too.

110 mg 5-MAPB, 25 mg 2-fma and <5 mg 5-MeO-MiPT was too much for me, I was totally faceblind and looked like I was dying. Felt like I was dying the next day, too.

I'm not a 220 cm tall Dutch guy though :)
 
Ok wasn't sure where to put this but I guess here is as good as any. I'm hoping someone can help me as there seems to be a lot of very informed posters around here. I purchased what I assumed was 5-MAPB, it came in a sugary crystal form, I tried about 60mg in a capsule on an empty stomach and had little reaction. so I tried about another 40mg nasally and it had me up and about very stimmy, happy, some euphoria, no pupil dialation, so I prob had another 100mg throughout the night, found it hard to get to sleep but managed to get about 5 decent hours and other than being a little tired I felt fine.

Ok so later that night against my better judgement a friend came around and we had it again, prob used another 150odd mgs and had a great night, my mate said it seemed like coke(we are both in our mid thirtys and have done a lot of different drugs).

Same again hard to get to sleep but did and woke up great, so I've been using it for the last 5 days like a stim and it's been great, I know that no body is going to be able to tell me excactly what I've got but I doubt there is much if any Seratonin usage happening(I certainly hope not), I'm going to give it a rest for a while just to be safe but at this stage it seems to good to be true, any thoughts?
 
Woaah, I would adivse to stop taking imediately!
Contrary to what you believe, there should be a lot of serotonin activity if what you got is really 5-mapb.
You should do some research beforehand... Some bluelighters reported suffering a horrible long term comedown for more then a year for taking this compound 3 days in the same week, one said he took it just 2 days in a row.
Those reports are somewhere back in these thread, try to find it. You should know your drugs better before taking them.
 
Thanks for your advice, I am giving it a break but I guess what I was trying to say was I doubt it's 5MAPB, I've had my share of MDMA over the years and two days of using in a row with that you have a fair idea it's time to stop, I know my body.
 
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