The LYRICA (pregabalin) Mega Thread

[Mora Fiend]

Lyrica - Diminishing Returns

To the Lyrica users out there that actually like it and use it recreationally, do you also experience diminishing returns with it? How do you avoid having to take more to achieve the same effect. Sometimes I wat a few days to get the same feeling, I understand that my GABA receptors are getting pounded by it, but my question is: Is there a way around it?

My prescribed dose is 1 150mg tablet 3x a day.

My recreational dose is 900mg.

I would like to avoid taking more than that to achieve the same effect day to day. I also understand it's more than likely impossible to do, however if you don't ask you won't know.

Any help appriciated in advance.

 

[bben]

300 mg lyrica in a tolerant user (3 months daily). Would it be safe to mix this with some moderate amounts (2-4 beers) of alcohol.

 

[Chainer]

I got some free samples of lyrica awhile back. I forgot about them for awhile but just happened to remember them a few days ago. I have been taking them up to today. Today I had to meet my parole officer and what not. Tomorrow I will be taking a swab test(maybe urine too). As fas as I can tell lyrica is not tested for on narcotic testing, at least for something like a UA or swab test. Was wondering if anyone here would know maybe from experience? Just don't want to get screwed over by this, although i imagine it's too late anyways even if they do. But some peace of mind would be nice. It would make sense that they don't test for it but who knows. P.S. I searched around for an answer here on bluelight specifically but wasn't able to find anything.

-- Thanks for your time

No (drug test questions allowed).

 

[delphinen]

I have been [ab]using this drug for these last months and I can only say that it seems that there is no other thing like this. Me- being a mild opiate user (Codeine and Tramadol once or twice per month) and a heavy benzo user, I feel like this drug is a bliss.

I fear so much all those drug that lowers your seizure threshold- yet this upper it. The feeling it's a mix of some ... kind of opiate... like.. I dont know.. mild Hydrocodone? and a mild stimulation like on XTC too... plus the benzodiazepine-drunkness feeling (although I always try the capsules with some Clonazepam .. ironically, for fear to seizures).

The tolerance goes EXTREMELY high from the first time you dose to the next 48 hours. Thats really bitchy. And the price, oh the price...

Anyway, its still like some junkie's dream (at least for those who like either benzos, opiates or MDMA) mostly because it OTC here :3

Lyrica+Naproxen+Clonazepam = Bliss

You sleep so fucking well its incredible what this thing does. I want more drugs like this.

Lastly, I have found that taking 750+mg plus 150mg snorted to enhance the trip is the way to go.

 

[ycomp]

Too Good to be True??

my question...

something awesome happened to me tonight...

I am pretty new to Lyrica (and melitor and afobazole for that matter). Lyrica I took first time 2 days ago 300mg... great mood for about a day.

I took this tonight before going out to a club:

2x75 mg Lyrica... maybe 2.5 - 3 hrs before
1 25mg melitor... 1 hr before
1 12.5 mg tianeptine/stablon - 1 hr before (I would take this a few times a week in general.. but this was first tablet perhaps in 7 days or so)
1 afobazole

http://en.wikipedia.org/wiki/Lyrica
http://en.wikipedia.org/wiki/Melitor
http://en.wikipedia.org/wiki/Tianeptine
http://en.wikipedia.org/wiki/Afobazole

I had no drinks for first few hours.. my mood was ok... like neutral but if someone said something funny I could enjoy laughing. but I was a bit fidgety and slightly anxious... most of anxiety was gone, but there was still some.

Then I started to sip some heineken... I took about 2 sips... only 1/2 the neck of the bottle was gone... and it hit me immediately! I still have no idea how it could've so fast.. but I was not imagining it, it was real.

all of a sudden I achieved what I only usually achieve through multiple strong drinks... and then not even sometimes...

- total loss of any anxiety
- some more energy - or desire to move, like not total desire to dance but some
- total confidence... this is what I really enjoy having in a club... my eyes become weapons when I'm like this... girls respond so well to it!
- better mood

So needless to say I'm ecstatic that I found a way to achieve this state by only having a few sips of alcohol. I polished off the bottle but I don't think it was necessary.

My questions are:

- is it solely the Lyrica?

- will I have to up the Lyrica dosage soon?

- do the other drugs help potentiate the alcohol? I know the stablon doesn't because I'm used to taking it when drinking

 

[drug_FUCKED]

I like doing Tramadol, Lyrica, Clonazepam and Alprazolam. Sometimes Naproxen too.
This drug it's really awesome, but at higher doses it DESTROYS your balance. And I mean it. IT DESTROYS YOUR BALANCE. I almost destroyed my PS3 and XBox360 because I fell on them BADLY on Lyrica.

Yeah tell me about it at high doses i have lost my balance for days.
The first times you have lyrica there is almost some trippy feel to it with slight changes in vision.

 

[Cane2theLeft]

My questions are:

- is it solely the Lyrica?

- will I have to up the Lyrica dosage soon?

- do the other drugs help potentiate the alcohol? I know the stablon doesn't because I'm used to taking it when drinking

It's impossible to say if it was solely the lyrica but I would surmise it was MOSTLY the Lyrica looking at the pharmacology of the others (none of which are available in the US AFAIK).

The afobazole IS GABAergic however it has no sedative or myorelaxant properties so I doubt it would substantially potentiate the alcohol.

The Agomelatine (melitor) is a 5HT2c antagonist and as such, increases the effect of dopamine and norepinephrine in the prefrontal cortex... this certainly may have impacted the effects you received-

This brain region has been implicated in planning complex cognitive behaviors, personality expression, decision making and moderating correct social behavior.SOURCE

This would not directly affect the alcohol effects (via potentiation, inhibition, etc.) but it may have in effect synergized with the anxiety-reduction, increase in confidence, etc. that you mentioned.

The Lyrica ABSOLUTELY potentiates the alcohol. It so strongly affects the alcohol effects that every Rx I received of it for 3+ years warned to never mix the 2... not even my morphine, oxycontin or lorazepam scripts ever had such a firm warning against the combination.

Throughout discussions of lyrica on BL its been said that large doses of Lyrica greatly resemble getting ridiculously shitfaced and that when consuming lyrica and alcohol together, far less of either is needed.

So....

In my quite amateur opinion... the afobazole likely had little to no effect, the agomelatine certainly could have indirectly contributed to the effects you received and the lyrica + alcohol combination likely accounts for the majority of the effects, possibly somewhat modulated by the other drugs.

Lastly, since you said you didn't think the tianeptine had an affect on the experience, I didn't address it and this would explain why it wouldn't account for what you felt...

Alcohol co-administration decreased tianeptine absorption rate and lowered tianeptine plasma levels by about 30% but did not affect those of the MC5 metabolite. SOURCE

 

[ycomp]

Lastly, since you said you didn't think the tianeptine had an affect on the experience, I didn't address it and this would explain why it wouldn't account for what you felt...

interesting, thanks for the amateur opinion.... it helps... what I do notice about tianeptine (1 pill) with alcohol in general, since I have much experience with the 2 together... is that the day after, usually I'm in a great mood in that everything is quite funny... if I watch craig ferguson on youtube, I laugh my ass off.

I think it is not just the tianeptine, but the tianeptine + alcohol combo the night before. Although, I should test some more tianeptine alone to know for sure.

I did try 3-4 times more lyrica than I ever had before, plus 2.. perhaps 3 drinks (dunno, because I was pouring it myself by sight) a few nights ago... and it was AWESOME ... I think I had either 1050 or 1200.. I think 1200mg lyrica. I'm a bigger guy (6'3 - 240lbs at least, perhaps 250) - so perhaps it is equivalent of 900 or less in smaller person, if these things affect you depending on your weight.

My friend was telling me I looked high... I had some problems with stumbling... if I did not concentrate on walking straight, then I tended not too... but wow, was it fun. Great mood, smiley - everything was great. No anxiety for sure. Food tasted incredible. I had lasagna, that was great and split a pizza with him... it was a nice restaurant, the pizza was actually really good quality but I enjoyed it much more (and it was my first time at that restaurant, so the pizza was new for me) but damn the pizza was almost orgasmically tasty... then after dinner I had a snickers bar which actually was orgasmically tasty for sure... and was still hungry so I bought a fruit drinkable yoghurt which I didn't really notice any difference in taste to than if I had been sober.

oh yeah, I did try the 150mg lyrica again before plus some alcohol and it did potentiate it but nothing near like that amazing experience the first time I combined the 2. I guess it was just a one-off thing.

 

[MihoSayuri]

will snorting 50 mgs of Lyrica give me any high? I'm trying to get more but I've only got a 50 mg capsule right now.

 

[Cane2theLeft]

^The oral bioavailability is equal to or greater than 90% so there isn't any reason to snort it (it doesn;t burn at all but it tastes bitter as hell). I always found it to be stronger orally

...but no, I doubt 50mg would do much of anything.

 

[ycomp]

I just did another ,.. shit I don't know... 1350 or 1500 mg. It was really mellow at first, my mood wasn't that great... but I didn't start the day well anyhow. I went to a cljub... it was ok but I was not social. Then I left and went and got a snickers bar..................

after the snickers and some "power water" (guarnana and stuff) but it tasted mostly like water so can't have much of anything in there.

affter the snickers, wow.... I Was "in the zone" again........

no anxiety, ... good confidence... and relatively social.

I also took 2 or 3 tianeptine and 3/4 of a gidazem pill.. I'm kinda new to benzos....

http://en.wikipedia.org/wiki/Gidazepam

But it did not affect my walking like the first time a few days ago where I was high on the stuff... I would not say I was high this time, just my mood as described. Good for meeting girls in clubs. Although one bitch that always looks at me in the club refused to shake my hand, when I tried to introduce myself...... I know she had the hots for me before, so what's up with that.. dunno.

She was saying something about her purse where I was standing, so maybe I was stepping on the strap... don't know... but who cares, she purposely steppe on ,my foot a few months ago to get my attention. And then looked at me like I stepped on it.. ok, she's crazy...

but this shit is good, I hope I don't build tolerance quickly....

 

[Cane2theLeft]

^You're going to rapidly jack your tolerance up increasing it at this rate.

 

[ycomp]

maybe I should take less and more benzo?

 

[Lazyscience]

You know what? I find that taking higher doses (over 800mg) is pointless. For me, it doesnt increase the enjoyment of the drug and only makes me less coordinated and drunk feeling.

The best thing for me with this drug is, it makes me feel so creative. I play guitar and record music and stuff but most of the time, I dont feel all that inspired to create anything. When I take this drug, I can sit and play guitar all day, coming up with great ideas and recording lovely spacey and ambient music.

 

[ycomp]

the less coordinated and drunk feeling also starts occuring for me around the time that I get the most of a mood boost from it. I'm thinking that time now is about the half life time.... 5-7 hrs into it. But I'm taking it so I don't have to drink so much when I go out clubbin

 

[Lazyscience]

I would like to say something about Fibromyalgia. Now, I experience pain daily in every part of my body. It drastically decreases my quality of life and makes me really miserable. It would be easy to diagnose myself with Fibromyalgia and I have gone to the doctors and said thats what I think is wrong with me.

The thing is, I just dont think any more that it is a real illness. Yes, the symptoms are real but I think they are the physical symptoms of psychological problems such as depression due to dissatisfaction in life. Actually, I think the symptoms are a normal reaction to the crazy pressures of modern life and all the stuff we have to deal with that we are not really evolved to do.

I thinks that realising the symptoms are psychological is the first step to recovery. If you give yourself a label like 'Fibromyalgia' then you are creating a belief that you have some kind of disease and you are stuck with it since there is no cure.

I think that, in fact, that you have to sort out the problems in your life, improving your psychological health, in order to recover.

However, this is easier said than done.

 

[heathergirl78]

I've been taking lyrica for a few months now. I think it absolutely wonderful. But it does have some negative side effects. I take way more than what I'm prescribed, go figure, which is one 75mg capsule every 12hrs. I take like 8 75mg capsules at a time. You build a tolerance to it once you take it enough. I feel euphoric off it and I have energy to do everything and anything. That may be because I mix it with ultrams/tramadols. I just got my script again but my doctor switched my tramadols to tylenol 3's. I don't particularly like the two together. I'm too groggy and sleepy. I want my tramadols back!
When I'm on them, I feel like my body is going wawawawa. It's a weird feeling. And I also see trails and colors like I'm tripping. I start cleaning because its like I get x-ray vision or something. I can see everything. And stuff is so much brighter. very interesting.

 

[Lazyscience]

Yeah is a weird drug.It makes you so uncoordinated and dizzy and you fall about but, somehow you still have the motivation to get stuff done.

Thats what I take, 8 X 75mg capsules and I feel great.I really enhances the music and Ive been dancing around in my living room all day and playing my guitar and singing like crazy .My neighbours must think im totally weird. Well, actually, I guess I am.

It does also cause mild hullucination like small anomalies. Sometimes for me, it seems like the lights are flickering in the room and I keep seeing objects in the corner of my eye. Its fine though, It doesnt bother me.

 

[ycomp]

wouldn't it just be easier to take the 150mg capsules you guys? then you'd only need 4... or is it harder for you to get those?

 

[Lazyscience]

For some reason, I can only seem to get them in 75mg capsules. I dont mind anyway they are incredibly cheap.