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Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

Youre overdoing it. Clonazepam, Diazepam, Tramadol, at the same time, at those doses?

Listen, Pregabalin withdrawal can be bad, but its not deadly. Youll get through this. Dont waste all these drugs to not feel the withdrawal. Its pointless and a waste of money.

The only drugs that could kill you when you go cold turkey, are benzos, alcohol and barbiturates. Dont throw in more benzos, for the love of god.
Exaggerating?? This is hell. And yes, I am taking those doses, and yes, I know it's a waste of money and all that shit. I've been taking benzos and opioids for years, don't tell me I'm exaggerating.
I have to deal with opioid withdrawal tomorrow, along with pregabalin withdrawal. Don't tell me I'm exaggerating.
 
Exaggerating?? This is hell. And yes, I am taking those doses, and yes, I know it's a waste of money and all that shit. I've been taking benzos and opioids for years, don't tell me I'm exaggerating.
I have to deal with opioid withdrawal tomorrow, along with pregabalin withdrawal. Don't tell me I'm exaggerating.
Wasting more drugs on it, while you dont have money to stock up on Lyrica, is a mistake though.

Youll go through it either way. Youve taken two benzos and Tramadol, which is like the shittiest opiate you can take, and yet youre stsill suffering.

Dont throw more drugs into your system. Suffer these couple of days, drink a lot of water, eat, if you can. Youll be alright.

I know it sounds harsh, but youll get through this.
 
Exaggerating?? This is hell. And yes, I am taking those doses, and yes, I know it's a waste of money and all that shit. I've been taking benzos and opioids for years, don't tell me I'm exaggerating.
I have to deal with opioid withdrawal tomorrow, along with pregabalin withdrawal. Don't tell me I'm exaggerating.
I for one feel your pain bro (Imma ramble for a bit but I will give u some recommendations further down as well).

I am also horribly addicted mainly to opiates and pregabalin. I am talking over a decade long addiction and I honestly find people that underestimate the withdrawal from pregabalin offensive and even dangerous. I have experienced withdrawal from a long pregabalin-only addiction before, I have experienced withdrawal from a long heroin, fentanyl, -name the opiate- addiction before. I have experienced withdrawal from a long alprazolam and diazepam addiction before as well and;
the pregabalin withdrawal is fuckin WAY worse than anything else I have experienced. And I ran out of new drugs to try a long time ago.. Opiate withdrawals are very bad. mentally as well but the main hell is the physical part. If you are withdrawing from a serious, several gram a day pregabalin habit, There is basically a CONSTANT panic + anxiety attack type feeling going on in your head and chest. I could NEVER imagine going through full pregabalin cold turkey withdrawal. When I tried, I was in the constant panic attack I mentioned (I know what a real one feels like) and my body was jolting randomly like I was being electrocuted. I could not move because every fucking nerve in my body was hurting. Not in the way opiate wd hurts, not less just very very different. I felt like I was going into psychosis because of the TOTAL inability to sleep and the constant SEVERE anxiety. My friend told me that the jolting was exactly what he was experiencing right before he suffered EP from lyrica wd so I could easily have gone into EP, choke and died. don't tell people to cold turkey.. ffs.

I have managed to get through opiate wd with very little "help". Its bad, "but it is possible", like someone said about the lyrica. I could NEVER and would never quit lyrica cold turkey. Its a totally different.. astronomically different animal. If I ever ran out and the shitty "doctors" in my country refused to help me I would 100% find the nearest fucking train track and wait for the express..". "lucky" for me I am able to buy several Hg's at once of pregabalin powder/crystals MUCH cheaper than the finished, expensive as fuck pharma product is sold for "on the streets" because I could never afford my addiction that way.

So, why I say it's dangerous to suggest anyone to quit pregabalin cold turkey is; because IT CAN be fuckin dangerous. Pregabalin differs VERY little from "benzos, alcohol and barbiturates" that certainly are not the only drugs that are dangerous to cold turkey on. A serious GHB withdrawal can also kill you, for example. The pregabalin high is actually very similar to GHB in higher dosages.
benzos, alcohol and barbiturates.. AND Pregabalin, GHB, gabapentin are all drugs that in some way or another have something to do with the GABA system. and they are all dangerous and they are all a real fucking bitch to wd from. Benzos are no different but pregabalin wd is basically like benzo wd on steroids with a side of heroin wd.

I have no personal evidence of pregabalin withdrawal actually killing anyone I know, personally (like I have with GHB) but my friend suffered his EP seizure while at the hospital where they were refusing to give him any treatment despite him begging for his life, telling them that he was dying. And as mentioned I have also been on the brink of possible death from this.

SO.
My friend. Not only is it not a "waste" to take benzos during your wd. you SHOULD use benzos during your wd. Diazepam and Clonazepam especially, because those two are frquently prescribed as "antiepileptics" (or whatever the fuck) and will help to keep you from suffering EP and possibly choke to death on your tongue. They obviously also help prevent the severe anxiety from turning into a full on panic attack. The hard part is not overdoing the benzos. You are detoxing after all, you will and u should feel like shit. only use the benzos when it gets really bad.. which will be, all the time honestly for a good little while. This is also a part that is different from heroin. The wd is much longer as well. with heroin I always feel like the main struggle is over after like 2 weeks. Its not over then but its generally down hill after two weeks, in a good way. When I was wd'ng from lyrica two weeks was just the beginning with no end in sight. I just could not do it. Like I said, i feel you and I am sorry you are going through this. There 100% is no other way to do it then tapering of SLOWLY. I dont remember exactly how my friend did it but it was something like lowering your current dosage by 10% every 3 weeks. or even longer, you will know if you lower it to much to soon because that panic attack knocks on your door as soon as you dont have enough pregabalin or benzos in your system. Like this; If u dont feel like shit you are taking to much. If you feel like you are about to die and your body jolts randomly, you are in the danger zone. Tramadol on the other hand is a very big no no because it LOWERS your threshold to EP. I am saying tramadol can kill you while in serious pregabalin wd. Sell your tramadol and buy benzos and or gabapentin. those two are your friends in this situation. I am not sure actually if gabapentin lowers or raises the ep threshold but I am thinking that it at the very least does not effect it at all. what I do know is Gabapentin and pregabalin are very similar drugs. Gabapentin is basically Lyricas weaker twin and works like a perfect substitute to pregabalin so you should be good. pregabalin has been confirmed to be 6x stronger than gabapentin so, dose accordingly (6:1).

As we are in the same boat basically, feel free to reach out. Ive been through this more than once.
I am currently trying to taper down my pregabalin and opiate usage. I was on mainly heroin/bupe and pregabalin along with every type of downer you can think of. I still am, minus the heroin which I managed to quit completely a while back by tapering my dosage and eventually replacing it with kratom. I buy a gram of heroin here and there very sporadically but I feel like I have that beast under control. My personal goal is not to quit doing drugs. My goal is, being able to live life without HAVING to do drugs all day every day. I want drugs to be enhancers of my life on occasion, not a requirement in order to get out of bed. I know this does might not be a popular opinion but I belive I can live life like that. I think the idea of "always in recovery" is a bad mindset to have. And sure, some people just naturally lack self control and for real cant smoke a joint or have a beer without spiraling into disaster in less than 24h. even after 20 years of sobriety. I am not looking down on those people but that is a type of personality that simply should not do drugs and never should have tried drugs.

I digress;
am currently working on tapering down the pregabalin and eventually the kratom. I am not in a hurry tho, taking my time because I have the privilege of not being drug tested at work and having a steady access to the drugs i need. Im not some drug kingpin, far from it. haven't sold a drug in my life, honestly.. its 2024, drugs are everywhere if you know where to look. and if someone has survived as long me doing this, one has not have to look far. It's a bless and a curse. I would have 100% commited suduko decades ago if it werent for illiegal drug use and that is just a fact. I owe my life to drugs and that is, just what it is. Anyway.

every time my tapering goes to shit is when I go to low to soon. my lyrica dosage at its highest was up to 5 grams, often more than 2-3 times a day. Right now, some days I feel fine with 300mg every 12h. some days are harder and I have to take more. I am kind of stuck at 300mg though I have tried taking 200mg and some days even 150mg but I can never stay there. Eventually (when the surplus pregabalin in my body wears of or something) that panicy feeling slowly creeps up and I have to go back to 300mg or add a bens/gabapentin. but I will not lie it has been a long road leading to where I am at right now. I assume your situation is not as bad when it comes to the amount and time youve been on your particular constellation of substances.

Regardless,
Feel free to reach out if you have any questions. I am a certified expert in feeling like shit due to detox or lack of drugs. And I am not "one of those people", who are into the whole 12 steps, AA, come to jesus .. stuff. not knocking on people who are, or if you are. But what I am saying is if you feel a need to talk or have questions I will try to help you, not try to recruit you or brainwash you. Im not saying everyone in AA does this but a good amount does. some people are damn near predatory on here I have noticed. Being in AA is an addiction/cope mechanism in itself and one should also regulate that usage. In my opinion.

Anyway, unlike some people I DO know what it feels like and you CAN get through it. It just takes some planning and a lot of determination.. and strong self control in order to not just become super addicted to the "helpers" instead. or even worse ADD more stuff to your addiction.

And my man (I assume you are a man), if you are not able to get a hold of the "helpers" or can't afford them, and your usage has been anywhere close to mine I order you to seek medical help. Because, again; it can definitely be dangerous, even if you are not at the point where it is dangerous physically. The evil fckin thoughts that can pop up when it is at its worst, are obviously dangerous. just as life threatening.

I am not trying to scare you or be dramatic. I just have first hand, second hand, fuckin ten hand worth of experience in precisely the situation you are in. One does not simply cold turkey from pregabalin. And one does certainly not simply cold turkey from pregabalin AND opiates at the same time:facepalm:.

Oh and by the way. I am mad depressed along with a general anxiety disorder even when I am not tapering down. Sooo yeah, I told you to reach out if u want but I can't guarantee I will be logged in here when you do. Sometimes I am here everyday, sometimes I don't log in for months at a time. Make sure you have someone to call when shit gets bad, call the hospital if you have to.

and yeah, good luck man. I will end with this in case you are in a similar life situation as me as well:
TRUST me i know what it's like to not have a single milligram of need to live and it might seem like there is no way out of the tunnel. I honestly still feel like that sometimes but I realized I have people that depend on me. shit, at least A person would be devastated and all alone if checked out from this life and I could never leave them alone here with all the shit.. all the shit people and just all the overall..shit. This fact keeps me alive and i promise that there is something, probably many things that are similar in your case. It does not even have to people; if u dont have any in your life. when you are done with the worst part of the wd things will start to brighten up if only just a tiny bit, and you will thank yourself for not ending it. Life has a habit of putting its boot on the neck of people that are not happy to begin with. Dont give that motherfucker the pleasure of defeating you. Fuck that motherfucker, get through the wd and THEN begin your plan of attack on life. Addicts are more often than not talented, special people that simply are not allowed to spread their wings in todays society. thats why it keeps the boot on your neck. You full potential is scary to todays society. Recover and give them hell, or it. whatever. I believe in you :p:peperave:
 
So I did a redoing test yesterday.

900mg at 10am

600mg at 2.30pm

300mg at 5pm

Was nice and relaxed in the morning, this is my usual dose anyway so was feeling warm and comfortable.

Second dose didn’t produce much feelings and didn’t extend the morning high.

Third one was probably a waste and did absolutely nothing.

This is just me and might be different for someone else but redosing was pretty poor effects wise. On a good note my anxiety was squashed but did feel a bit empty in a way.
 
There isn't a way to directly potentiate pregabalin.

I mean you could combine it with phenibut, gabapentin or even benzos, but this wont result in the potentiation of pregabalin. Instead you'll just experience additional effects from the combo.

I once had a 900 mg per day pregabalin prescription (3 of the 300mg capsules). There was no good reason for me to take it, i just sort of convinced my psychiatrist it was a good idea. The effect of the pregabalin was very unique; I would take the 900mg all at once in the late afternoon (around 5pm) And it would produce this weird sedated mania, with some empathenogenic qualities. It had an unusual nihilistic headspace where nothing mattered And that was okay because nothing mattered. It killed any ambition i had in life due to this existential mindset. Once i finally quit pregabalin, along with some other psychiatric medications I had no business taking (like huge doses of pregabalin and the antidepressant mirtazapine), i felt suddenly awakened and had urge to do something with my life. Not long after I applied to graduate school and was accepted, thereby moving forward with my life.

While phenibut and gabapentin have ambition killing effects, they do not produce a headspace like pregabalin, which is almost psychedelic like at high doses. And I have never felt much of a high at all from phenibut or gabapentin, although both can produce a similar mania, and phenibut has some music enhacing effects. But pregabalin was very different, producing both a high and unique mindset.

There definitely is a way.
I never really feel the anxiolytic effects anymore but I use pregabalin to potentiate, literally any other drug / medication.
But I am 100% positive that omeprazole, 20-60mg 30-60 minutes before taking the pregabalin potentiates significantly. For me at least. omeprazole also potentiates most benzos in my cases. again, significantly. I discovered this a few years back when my tolerance got to that point when I did not get "high" from it anymore. But then one morning I took 40mg omeprazole with my lyrica and a relatively small dose at that ,in my case. I went about my summer day sippin on a monster energy drink and from nowhere I got.. very fucked up. It was like one of the very first times I got high on pregabalin again. So today when I take pregabalin only and looking to kill anxiety I usually take omeprazole before or even just both at once. omeprazole increases / decreases, inhibits, enhances.. It has something to do with one of those CYP enzymes and I find it to potentiate some benzos as well. I think it works better then WGPJ.
 
There definitely is a way.
I never really feel the anxiolytic effects anymore but I use pregabalin to potentiate, literally any other drug / medication.
But I am 100% positive that omeprazole, 20-60mg 30-60 minutes before taking the pregabalin potentiates significantly. For me at least. omeprazole also potentiates most benzos in my cases. again, significantly. I discovered this a few years back when my tolerance got to that point when I did not get "high" from it anymore. But then one morning I took 40mg omeprazole with my lyrica and a relatively small dose at that ,in my case. I went about my summer day sippin on a monster energy drink and from nowhere I got.. very fucked up. It was like one of the very first times I got high on pregabalin again. So today when I take pregabalin only and looking to kill anxiety I usually take omeprazole before or even just both at once. omeprazole increases / decreases, inhibits, enhances.. It has something to do with one of those CYP enzymes and I find it to potentiate some benzos as well. I think it works better then WGPJ.
I’ve always heard about this but never tried it before.

Interesting.
 
Not pregabalin but I superstitiously use apple cider vinegar to potentiate gabapentin. To me pregabalin is plenty strong. But I guess if a person is on it daily seems logical to find a way to make it stronger.

I am astounded at the short half lives of pregabalin and gabapentin. It seems even 24 hours later can be 5 half lives, at least at moderate doses. That always confused me as the duration of action seems longer than the half life.

There was a thread in N&P discussing duration of action verses half lives. Been looking for it.
 
There definitely is a way.
I never really feel the anxiolytic effects anymore but I use pregabalin to potentiate, literally any other drug / medication.
But I am 100% positive that omeprazole, 20-60mg 30-60 minutes before taking the pregabalin potentiates significantly. For me at least. omeprazole also potentiates most benzos in my cases. again, significantly. I discovered this a few years back when my tolerance got to that point when I did not get "high" from it anymore. But then one morning I took 40mg omeprazole with my lyrica and a relatively small dose at that ,in my case. I went about my summer day sippin on a monster energy drink and from nowhere I got.. very fucked up. It was like one of the very first times I got high on pregabalin again. So today when I take pregabalin only and looking to kill anxiety I usually take omeprazole before or even just both at once. omeprazole increases / decreases, inhibits, enhances.. It has something to do with one of those CYP enzymes and I find it to potentiate some benzos as well. I think it works better then WGPJ.
But pregabalin is not subject to hepatic metabolism, the induction or inhibition of the P450 system (CYPs) should leave it unchanged? The bioavailability of pregabalin is also what? 98%? So it can’t be that it increases bioavailability?
I wonder what the reason for potentiation could be.
 
Not pregabalin but I superstitiously use apple cider vinegar to potentiate gabapentin. To me pregabalin is plenty strong. But I guess if a person is on it daily seems logical to find a way to make it stronger.

I am astounded at the short half lives of pregabalin and gabapentin. It seems even 24 hours later can be 5 half lives, at least at moderate doses. That always confused me as the duration of action seems longer than the half life.

There was a thread in N&P discussing duration of action verses half lives. Been looking for it.
Something I find interesting is that it has a tmax of <1hour (empty stomach) but the perceived peak is after ~2hours
 
I have tried pregabalin in a few ways but so far I’m happy with 600mg once of dose and it feels so good and last a long time.

Think I will be using it more when I feel like relapsing so to speak
 
Hey guys, new to this thread but I’ve read a decent bit of it and there’s some useful stuff in here.

I’ve been doing pregabs/lyrica a couple of times a week, last week three days, and it’s probably getting out of control. I’m not using every day and don’t think I will but I use a lot when I do use — over a gram in redosing, I just find it so moreish, and I’ve gained confidence doing what I’ve been doing that I can handle a high dose. Most I’ve done is 2.1g on the second time I did two days in a row since there seems to be some kind of extreme short term tolerance if I do two days in a row. Anyway will be going to a friends and taking a week off everything but had a couple of questions.

I tried plugging it cause why not, I’d just eaten and didn’t want to wait — 900mg done in 300 mg doses over two hours. Three hours after last dose i still had nothing. Psychonaut claims great availability and peak faster, I felt like I got a slight something right away and then that faded to pretty much nothing.

Ended up doing 1350mg in three doses orally and felt great. The first 600mg blew the maybe something from plugging out of the water. I’ve searched and seen a couple people talking about plugging it but has anyone here actually done it, was it as underwhelming as I found it?

My other question is next day after large doses, do you guys still feel affected by it? It’s almost the afternoon here and my hands are still slightly jerky, head full of cotton wool a bit tho in an enjoyable way. When I got up at 7 and went to the toilet I was bouncing off the walls. Passed out cause I hadn’t turned off tv or anything, I find pregabs + getting actually tired leads to me just passing out, even tho I don’t find them sedating really.

Sorry to post a whole wall of text but you guys seems really experienced, I’m new to gabapentinoids.
 
I’m not a 100% on this as I can’t back it up, can’t find the medical research thing. Anyhow
What it said is that there is almost like a ceiling effect between 600-900mg once off dose. There after redoing doesn’t really add or help much. Think it said to wait 4-6 hrs before redosing. If I find the article I will post it.
 
So I tried the omeprazole before Pregabalin (out of curiosity really) and just felt the same. The dosage was 40mg Omep and 600mg Pregabalin.

Was gonna get the esomeprazole but they were dearer than the original but same effects anyway from when I took them for acid reflux years ago.
 
Hi folks, I have a lot of experience with gabapentin but I'm finding my way with pregabalin. Hias dosage I've taken is 200 mg. I'm aware of tolerance develops quickly and it absorbs better than gabapentin. What's a good dose to like catch a buzz off it? Should I try like 400 mg? I'm not looking to transcend if you know what I mean, just looking to catch a good buzz. Thought I would post it here. I apologize in advance since I'm sure this information is easily found but I thought I would just ask in the thread instead of making a new post.
 
Hi folks, I have a lot of experience with gabapentin but I'm finding my way with pregabalin. Hias dosage I've taken is 200 mg. I'm aware of tolerance develops quickly and it absorbs better than gabapentin. What's a good dose to like catch a buzz off it? Should I try like 400 mg? I'm not looking to transcend if you know what I mean, just looking to catch a good buzz. Thought I would post it here. I apologize in advance since I'm sure this information is easily found but I thought I would just ask in the thread instead of making a new post.
There are people more knowledgeable than me in this thread but I think the general recreational dose is 300-600mg. If you’re not tolerant I think 400 would have you feeling good. 400 shouldn’t have you wrecked if that’s what you mean by transcend but should feel nice.
 
Hi folks, I have a lot of experience with gabapentin but I'm finding my way with pregabalin. Hias dosage I've taken is 200 mg. I'm aware of tolerance develops quickly and it absorbs better than gabapentin. What's a good dose to like catch a buzz off it? Should I try like 400 mg? I'm not looking to transcend if you know what I mean, just looking to catch a good buzz. Thought I would post it here. I apologize in advance since I'm sure this information is easily found but I thought I would just ask in the thread instead of making a new post.
What's your highest dose gabapentin you do or take? Like stagger up to? And what dise does gabapentin start hitting you. Easier to answer the pregabalin dose. As I know gabapentin as well very good and know what pregbalin does I need for said gabapentin dose
 
Gabs are hit or miss. I tossed my original rx because I was convinced they did nothing of value.
Then my doc said try Lyrica. Hits every day at 450 mg; taken at once or staggered.
Gabapentin was a nightmare compared to Lyrica poor replacement
I could take 10x (4500 mg) staggered and I swear it just gets me to baseline feels like;
 
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