Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

[ĐmantuNJofra]

Good thing or getting it for free every 14 days for 3 years, sometimes I think if the price is just not covered by insurance by employment, maybe I would be free of it!
couple months back when I started loosing feeling or tingling above the knee,(fybro-neuropathic) It started getting real purpose as real help with the some of the pains are gone!
With that in mind skyrocketing tolerance sometimes just go baseline! Who will know with those "gaba-modulators" VGCC or whatevers!

I didn't take any a week last week as I tried to cut back the dosage with Phenibut which is something I do like couple times a year
What happened is that I was like in this loop of Anhedonia but thinking I know a thing or two on all those Gabapentinoids, and what happened is Phenibut this time made 2+2=5, couldn't get the right dose, was vomiting and I think I first time got like manic state where I couldn't have couple straight thoughts I could just call my doc to refill my lyrica but on friday we had the Vukovar comemo day which is national holiday and doc didn't work!

Then on saturday I felt fine took 2gr Phenibut and bam anxiety, boiling blood for the lack of better term, racing heart, I didn't slept 8 hours in total that week just, I lost vitamins, maybe low blood sugar.

He who walk the road of Gaba-meds knows or can relate with the mad curvy road with CEVS, Oevs, hypnagogia,

So yesterday I collect myself in the head like lyrica is my demon and saving grace or at least devil I know!
Phenibut is from now a NO-NO in my collection cause side effects are there! with no effects!
Good thing I don't work one more week, I was alone most of the days which was another good thing.

Recent blood tests have shown I have reduced kidney function which could be due to me abusing high doses of Pregabalin for the last couple of years.

So I'm giving it a long break.

This is something I will need also get looked at, but in my case when I just hold back a little they work like turbo!

Pregabalin is addictive and it work better than any benzo in my case for anxiety made by anxiety meds in the first place and I will deff. continue to take it till it stops working

Baclofen was a long time ago but it was unpredictable also,

Maybe Mirogabalin which should be what like 10x stronger when it hits the market!, till then
O and I could have change it to gabapentin but my psych said, You can but you won't do any good just will have more side effects, 450 mg Is deff best sweet spot if taken at once with coffee followed by 150mg later for sleep, my circadian rythm is f. so

One thing I regret is the fact that I got myself addicted to Lyrica. I should've left it to be taken as needed only.

That is now something I still thing can be managed, will see in following days.

 

[ĐmantuNJofra]

stabilized or out of loop of Phenibut it was 50g in two weeks, maybe couple days more but now after todays migraine which is something that I never suffer due to buprenorphine 2mg and with bupe 2mg 300mg pregabalin morning and 300night with Concerta 36 and lorazepam if needed, stabilized but memory of phen trippin??
I still feel like I was tripping two weeks cause Phenibut is great drug but just not for my normal life, when partying or something that lasts couple days this vendor is fast in delivery!

 

[higherconciousness]

They want to prescribe this one to me for neuropathic pain/fibromyalgia. Not sure yet if I wanna do it or not. They all say it's basically non-addictive, but then I read a lot of people who think otherwise...

In my own experience, having been addicted to nearly every substance possible and enduring their withdrawals, lyrica is the one drug I can use for a month or so straight and stop without experiencing severe withdrawals. I felt mildly uncomfortable for a week perhaps, but nothing like opiate or benzo withdrawal. However, everyone reacts differently to various compounds as it’s quite evident that some have had trouble with withdrawals.

Lyrica is always in my arsenal of drugs. It’s highly effective for neuropathic pain and anxiety disorders when used in therapeutic dosages. It’s also very recreational when used in higher dosages and combines beautifully with other substances.

 

[johngeologist]

In a brief search using Google, Google Scholar, Bing, DuckDuckGo I failed to find ANYTHING. Safe dose ranges, studies, case reports of nothing, but there are warnings of this combination (which seems pretty obvious), including official ones from drug regulation agencies, but usually not backed with any scientifical data, only some wild guesses. In general any evidence about gabapentinoids safety, safe dose ranges, short-term and long-term toxicity, physical dependence potential and withdrawal, and so on, seems pretty scarce, in comparison to, for instance, most benzos. And as I'm now in pretty steep taper from high-dose pregabalin and have to take opioid analgesic (100-150mg codeine tid-qid), I don't really feel safe in this combination.

 

[negrogesic]

You will not find such data. These sorts of things are rarely studied in such an explicit fashion (ie, what dose of pregabalin is safe to combine with opioid x), unless said combination is particularly toxic, or the interaction has therapeutic implications (for instance combinations of antiviral medications). This is because, if there hasn't been an especially significant problem with the combination (or if there isn't a potential economic gain knowing the results), no one will fund the research.

Generally gabapentinoids increase the risks posed by opioids to a degree (though significantly less so than benzodiazepines). There is some research on this risk (they defined high dose pregabalin as above 300mg): https://www.acpjournals.org/doi/10.7326/M18-1136?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub 0pubmed

Essentially you have to evaluate your own risk factors (age, respiratory function, etc) and tolerance to both drugs to assess the risk. This is what also makes such research difficult and unattractive since it is almost impossible to conduct research and conclude, "a safe dose of codeine and pregabalin is X mg and Y mg" since risk factors vary widely, and ignores the phenomenon of tolerance.

 

[mdaniel80]

relevant though not peer-reviewed data:

Opioids - Phenibut and mu-agonist potentiation

I thought i should bring this up, as i don't seem to see it specifically addressed, and i feel like we should because someone could easily dose phenibut with heavy opiates and die. IME, phenibut potentiates kratom and regular mu receptor agonists by what feels(subjectively) to me like somewhere...

bluelight.org

Combining phenibut and opiates?

Does anyone have any experience combining phenibut with opiates, specifically heroin but any true opiate as opposed to kratom? And if so how where the effects? Did you find the respiratory depression to be greater or lesser than with benzodiazepines? I have combined it with kratom before and I...

bluelight.org

 

[TGuru]

Everyone is talking about 600mg treshlod 600mg because of seizures.

I’m on bupe 8mg daily and once a week I took 1g (1000mg) of it and the synergy is fucking great,
I have now WD’s from Lyrica howerer, I’m doing it for a couple of years.

600mg is prescribed.

 

[ghostfreak]

I try and take it before a meal but if it’s a light meal (sandwich or something) I can dose 30mins and don’t notice much difference.

 

[vacuole]

It's more mildly drunk if you're lucky, which isn't...to my understanding of the word "euphoric".

That feeling would only be euphoric to someone who's never taken anything.

That's bullshit. GABAergic euphoria can range from subtle to overwhelming and nauseating, and to say that you must be a druggie n00b if you get euphoria from it is ignorant at best, insulting at worst.

 

[kongoman]

Today I took 900mg pregabalin with 240mg methadone and I feel almost nothing. I have trembling hands and tics in limbs.
Im dissiluniosed with this drug. I take at night to help sleeping and one day a week to potentiate methadone. But today only feel side effects.

Kongoman

 

[plumbus-nine]

I have trembling hands and tics in limbs.

Got this too, at high dosages (<900mg) and then I got a seizure from 1.6g, dosed so high cause I was desperate for a high and the lower dosages didn't do anything anymore. I think this is a warning for seizures to come if you dose any higher.

 

[kongoman]

When you talk about seizure, I dont understand because there are diferent kind of seizures. I look in the traductor and it says convulsions.

Kongoman

 

[plumbus-nine]

When you talk about seizure, I dont understand because there are diferent kind of seizures. I look in the traductor and it says convulsions.

Kongoman

Yeah, convulsions. Didn't see a doc so Idk what specific kind of seizures it was. I passed out and my girlfriend who was with me said she watched me having convulsions and talking weird stuff. Couldn't walk for two days after this incident and first had some difficulties remembering things so I was afraid of having damaged my brain but thankfully stuff recovered rather quickly.

 

[Woooooowwyyyy]

Hi, for the past 12 days I have been dosing around 900mg. Should I expect some gnarly withdrawals? I won’t have any for 15 days.

 

[James Peach]

I’ve never taken lyrica but I take gabapentin daily, usually exceeding my prescribed dose. 12 days 900 mgs I understand is a lot that is like 2,400-3,000 mgs gabapentin I think (I may be wrong). You should be fine unless you just finished withdrawals from pregablin and restarted for 12 days, in that case maybe.

It might be uncomfortable at most I’m guessing

 

[Woooooowwyyyy]

I’ve never taken lyrica but I take gabapentin daily, usually exceeding my prescribed dose. 12 days 900 mgs I understand is a lot that is like 2,400-3,000 mgs gabapentin I think (I may be wrong). You should be fine unless you just finished withdrawals from pregablin and restarted for 12 days, in that case maybe.

It might be uncomfortable at most I’m guessing

I did just finish withdrawals but during that time I was off for 10 days. I re started for 12 and dosed a tad heavier this time around.

 

[James Peach]

Hmm I guess I’d assume insomnia and uncomfortable sensations for 2 days. Shit sleep for 4-5 maybe. I hate when I run out of my gaba cause I dose more than I’m prescribed but fuck a junkies a junkieee

 

[higherconciousness]

Well shit, I ran out of lyrica a few days ago and am concerned customs nabbed my package. Was shipped from overseas on the 3rd so it can just be the holidays, but usually it’s here in 9-13 days tops. Have had Covid and the lyrica seemed to really help with the body aches, nausea, and appetite, but now I’m having mild lyrica withdrawals on top of Covid.

 

[Forever Changes]

In my own experience, having been addicted to nearly every substance possible and enduring their withdrawals, lyrica is the one drug I can use for a month or so straight and stop without experiencing severe withdrawals. I felt mildly uncomfortable for a week perhaps, but nothing like opiate or benzo withdrawal. However, everyone reacts differently to various compounds as it’s quite evident that some have had trouble with withdrawals.

Lyrica is always in my arsenal of drugs. It’s highly effective for neuropathic pain and anxiety disorders when used in therapeutic dosages. It’s also very recreational when used in higher dosages and combines beautifully with other substances.

When you say recreational in higher doses, how much are you talking about roughly? And what other substances does it combine well with?

I've found that tolerance increases very rapidly and never seems to go back down

 

[higherconciousness]

When you say recreational in higher doses, how much are you talking about roughly? And what other substances does it combine well with?

I've found that tolerance increases very rapidly and never seems to go back down

My ability to build up a tolerance to lyrica has been kind of all over the place. I’ve been using it relatively consistently for past couple of years in stints of 3-4 month binges with some breaks in betweeen. Dosages have ranged from 300-450 all the way up to 1200mg daily. Sometimes tolerance doesn’t build too rapidly and goes back down quickly. Other times it seems like it’s the inverse, so it’s been quite of unpredictable in that regard.

I think it mixes well with all substances, perhaps not in excess with alcohol, but especially with benzos, somas, stimulants (in low dosages), psychs, and dissociatives.

The past few months I managed to stay below 600mg, but that was mostly due to being in school. Seemed like anything of 300-450 mg would start to inhibit cognition, so I tried to keep in lower range. Now I’m completely out. Usually the withdrawals are pretty mild and manageable for me, but I think the fact that I have Covid is making it more difficult.