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Gabapentinoids The Lyrica (Pregabalin) Mega Thread v 2.0

Hi All, i keep trying to reply, but everytime i failed so i gave up yesterday and i hope that these words can be seen when i hit 'post quick reply'.

I see that a crash is mentioned after you would dose first with 1,000 mg's, but lyrica acts quite long in spite of it's only six hour halflifetime so when you know that the 900 mg i always take at 9.30 in the morning still leave me feeling good until way into the evening basically i would sleep trough my evenings would i not use alarms to wake me up else if i slept too much then my sleep at night gets compromised.
By the morning i sweat quite a bit, but it cant be lyrica withdrawal as this stuff reaches a maximum bloodlevel in about an hour so when an hour later i still sweat and when only taking my methadone with some benzo makes it stop its opiate/benzo WD still its a bit strange that after almost a year using lyrica on a daily basis that without it i dont get hit by a bad withdrawal whereas i read about people who use it say 3 months then stop for whatever reason and often heavy anxiety is reported.

Lyrica certainly has recreational potential, but if you like the feeling what lyrica can give you, i love it and then especially at first when this typical lyrica euphoria hit me it took 3 hours to feel good after taking 900 mg, then do not use it daily, but preferably no more then twice a week. When its a necessity that lyrica has to be taken for fybromylagia, GAD or some form of neuropathic pain OR as a sleeping aid to cry outloud, but anyway if lyrica needs to be taken then its best to dose twice daily and if your doctor told you to then take three times a day a dose then on the last way you create an as steady as possible bloodlevel for pregabalin without strong fluctuations in bloodlevel for pregabalin like if you dose just once daily.
Its said that lyrica needs some time before it acts, but when you start using it and in say 2 days you are already at the max recommended dose of 600 mg a day if you can tolerate this then already by then the complaint you use lyrica for will lower or vanish so when you know that lyrica in 50% of cases can result in 50% or more getting better and in case of being in the other 50% relief is less optimal and for some people lyrica does not act at all in not any way.

Now in case withdrawal symptoms for pregabalin can be expected and felt already then never stop lyrica from your used to daily dose to zero right away if lyrica is your main medication type so always taper guided by how you feel and not guided by what Pfizer says stating a week taper is enough, but certainly not always. Sedating low potency neuroleptics like thorazine or nozinan help sleep and anxiety, taking a benzo while on lyrica can be done just dont take much benzo as lyrica potentiates benzo´s strongly so whenever you might need a benzo it wont work if before you always used it combined with lyrica, except if you increase the benzo dose quite a bit.

I believe lyrica is available in the UK since 2004 about at the same time when it came available in my country the NL, but for one condition lyrica can be had in Europe and not in the US so that would be Generalized anxiety Disorder and for that reason it can work very well. In the US lyrica is schedule 5 so it has a low abuse potential, but i expect the substance to become schedule 4 in time, because i think people can become addicted to lyrica chasing that initial buzz who wont happen anymore so somewhere you find yourself with 3 gram lyrica needed a day just to feel normal like myself.
Side effects were largely absent in both the 900 and 3,000 mg doses, because i slowly upped the dose so slowly i got used to it´s side effects like blurry vision, dizzyness, sleepiness and so on, but at the moment the same 900 mg´s still act as anti depressant and better then SSRI, SNRI, NassA´s, tri cyclics and MAO inhibitors ever did for me.

For me to feel real good again with pregabalin i only have to skip it for about three days, but this is not so easy even when i dont have severe WD symptoms i definately miss the medication when i dont take it for a day here or a day there. Well i better end here before i write half a novel.
Regards, Freek.
 
I find that I need 3x 300mg per day instead of my prescribed 2x 300mg, because two doses per day don't last long enough and leave jittery "rebound" effects in between.

My doctor reluctant to prescribe more than 600mg per day because "it will be toxic, hard on the liver", but he couldn't tell me more than that. Why was the 600mg threshold set? And what is known about negative effects when going above that daily?
 
I'd be worried about pushing your tolerance higher

But what type of toxic effects occur when going above 600mg p/day?


How is 3x 300mg more unsafe than 2x 300mg?


Assuming that I take tolerance breaks and keep my dosage stable at 900mg p/day.
 
I am not sure to be honest, I don't even know how much we really know about the toxic effects of Lyrica. You might find that Lyrica works similiarly to Gabapentin in that staggering your doses and maybe drinking WGFJ will increase any effects you are looking for.
 
But what type of toxic effects occur when going above 600mg p/day?


How is 3x 300mg more unsafe than 2x 300mg?


Assuming that I take tolerance breaks and keep my dosage stable at 900mg p/day.

Not sure about toxicity, but IME, it fucks with your sense of balance above ~550-600mg p/day. That sucks, your walking into walls n shit, fucking retarded man, it can't be good if you can't even walk straight...
 
Hi, side effects from a higher dose then 600 mg will probably not even be there when on 600 mg you have no side effects and you only like to add 300 mg.
Maybe a little bit of side effects like a little blurry vision, dizyness, balance issues, but those side effects were present in the beginning and in about 3 weeks i would say side effects stopped from occurring while the benefical effect still continues at 900 mg a day.
900 instead of 600 mg in three doses of each 300 mg is not really more dangerous then taking twice daily 300 mg, but if you never messed with higher doses above those 900 mg then i think adding those extra 300 mg´s could actually make you feel good and when you do try not to get tempted and use more then 900 mg else if you would take say 1.5 gram a few times then the 900 mg could stop working, but alright you wont take more.

Toxic effects frm pregabalin hmmm i cant say i had any when i took 3 grams a day, but strangely enough as lyrica is an anti epilepticus med if you take too much then you can get violent seizures, but other toxic side effects i have no idea and my guess is that lyrica would only show to be toxic in very high doses like 5 grams plus.
I said it before, but i mention it again so what i mean is that lyrica combined with cannabis delivers a very nice effect without having to fear that this combo could OD you, but combining lyrica with other CNS depressants should only be done under doctor´s advise a problem though is that many of us as patients know more from medications required then a doctor, but they severely dislike it if for example i ask for this and that med once a doctor said to me the office is not a supermarket where you can order what you like, sure doctor i said and i took off with ten days worth of rohypnol stuff i only could get by asking for flunitrazepam in the hope that the doc doesn´t know the word and with the ten days worth of rohypnol the doc didn´t know so i was lucky.

In the beginning when i started lyrica i had these balance issues, dizyness, walking into walls stuff like that, but lyrica felt that good that those side effects were taken for granted and in about three weeks i was at 3 grams a day, but without side effects and also without desired effect so when i dose daily as prescribed makes me on the long run feeling much better then to keep taking lyrica in very high amounts to feel it again only that didn´t happen so i forced myself down to 900 mg, which was easy enough without dependence yet. From there i kept taking the 900 mg and am anxious and depression free so take it as prescribed, but also say something if it doesn´t work well enough atfirst so that the dose can be upped provided you tolerate the higher dose and being able to tolerate side effects made 600 mg te highest prescribed dose as most people wont get more benefit from a higher dose just not everybody like myself and the above poster who likes to start 900 mg daily.
I think that the upperlimit in mg´s with lyrica is at 1200 mg a day(the max therapeuthic dose that would be not max recreational), but that means 600 mg is not enough still that will stay the max recommended dose with most people saying they already cant take 150 mg due to the side effects according to the shrink i see. Well until here.
Regards, Freek.
 
Perhaps the trials done with Pregabalin for GAD showed that dosages above 600mg were not really any more effective than 600mg/day for treatment of symptoms of anxiety? Or that 600mg/day was seen to be an optimum dose when balancing desired effects against side effects. Just a thought.

Anyway, I've been reducing my daily dose from 600mg to 200-400mg, in the hope that I'll be able to more easily enjoy occasional recreational use of this drug again. I've not yet tried going a whole day without any Pregabalin yet, but can report that dropping down a few hundred mg over a week hasn't caused me any obvious WD. This is after about 4 months of daily use.
 
Some might say im a dirty b*****d drinking urine after taking pregabalin but if i take say 1000mg and then over the next few hours drink my urine (which has 90% of unchanged pregabalin) i get a buzz that lasts a lot longer.
Ok so drinking urine is horrible it makes you want to barf BUT if you get some STRONG fruit juice or cordial (I used welshes purple grape juice with a little water) then when you pee in the galss of cordial and drink it you honestly cant taste the urine at all!!
Its like theres no pee in it.
Any way just my thoughts on how to drink urine without wanting to puke up ! lol
 
Does this lyrica prove effective for social anxiety disorder and is it similat to benzos,e.g short term memory loss and a depressant effect?anyone got info on this thing?
 
I've been reducing my daily dose from 600mg to 200-400mg, in the hope that I'll be able to more easily enjoy occasional recreational use of this drug again. I've not yet tried going a whole day without any Pregabalin yet, but can report that dropping down a few hundred mg over a week hasn't caused me any obvious WD. This is after about 4 months of daily use.

Do you take your dose all at once, or spread out over the day? I spread it out and when lowering my tolerance I find it easier to skip an evening dose than an earlier dose.
 
Yes lyrica makes me soo talkative and is the perfect drug for social anxiety because it doesbt bring much sedation ans makes me rest really talkative which is something I love because most of the time I could care less to talk
 
Hi All, the withdrawal from lyrica well to start with if you like to know IF lyrica gives you withdrawals, in most cases it wont, then just skip a day not only a dose just a day then chances are high that more then a little insomnia will not be experienced.
Now for people with anxiety issues who take lyrica, and who get anxiety relief from lyrica, then for those people withdrawals in the form of heightened anxiety can be expected much faster then compared to somebody who takes lyrica without having anxiety issues. This could be slightly compared with a benzo WD, but a lyrica withdrawal can be bad just never as bad as a benzo WD can get, so whomever who started using a benzo for anxiety relief then this relief will be had and when the benzo will be stopped before its even remotely possible that dependence occurred then anxiety levels will go up and this feeling can be mistaked with a benzo withdrawal.

To become benzo dependent taking a benzo for a month wont make that happen beware for the high potency benzo's though, alprazolam and clonazepam especially, but behind say three months some dependency can be expected and if desired taper your benzo from there then when it comes to lyrica withdrawals i take this stuff already for a year or so, but if i stop it a day here or a day there trying to get the initial effect again then i dont feel bad from lack of lyrica.
At the same time i read about people who do lyrica for a few months and report bad withdrawals comparable with benzo's, but where lyrica can fully cover for a benzo WD this does not work the other way around in the same strength still a benzo can help possible lyrica withdrawals and what also helps are anti histaminics for a better sleep like somecan be had OTC in the US.

Lyrica is not approved for GAD in the US, but more doctors recognize this effect and write for pregabalin as pregabalin can be very effective for anxiety problems just not for everybody. If you think you could use lyrica ask your psychiatrist or your MD its a schedule 5 med so it cant be too hard to get it.

What's more ah the question if lyrica is taken once daily or multiple times a day, but i take it once daily in the prescribed 900 mg and its my opinion that if you take more doses a day that this could speed up the time needed to take lyrica before you could experience withdrawals. I do hope that i am wrong with that assumption though.

Talkative and social anxiety gone yeah that is the effect what you can get if you take lyrica say two times a week maybe three times are possible without becoming dependent, but twice weekly is not enough to become dependent from lyrica and taking it in that low frequency leaves lyrica's recreational potential at an optimal level. After becoming dependent and recreational became history then taking no lyrica for 3-4 days and by day five chances are high that it makes you feel very good again whereas for most people who take lyrica daily this med also has an anti depressant effect, atleast for me it does.

I dont have GAD, but i could imagine myself a strong effect against this badness from using lyrica based on how the substance influences myself, which is rather subtle after i dont know howlong taking the 900 mg daily, but what i like to smoke after about three hours when lyrica acts for me that would be cannabis and this combo is just very good when you like a four hour plus cannabis effect.
Lyrica also potentiates substances and then especially substances who work on te CNS like benzo's, anti psychotics, opiates, amphetamines and methadone being an opiate ofcourse, but i like to say it a few times not to combine lyrica with methadone for it's danger, and so combined use of lyrica and other CNS depressants will often result in excessive sedation so if you have a certain combo of meds and lyrica is desired then if it can be had find out first how it reacts, in a low dose, with the other meds.

WTF drinking urine for it's pregabalin content damn some people really go far, but doing this is not completely insane, because pregabalin will be excreted unchanged, but it has a 6 hour halflifetime so for example when you took 600 mg then 6 hours later roughly 300 mg is in your urine and so on so if you dont get lyrica prescribed having no lyrica left then it makes sense to drink urine after using this med, but i certainly dont recommend this.

Lyrica is not similar to benzo's and it's effect can be reproduced every day again, but lyrica has this tendency to 'poop out' after a while using it with success and that sucks so the only thing i can think of when this happens is to stop taking lyrica for atleast a week and start it up after that week again then your chances for a good effect again are present, but in general try to keep your dose as low as possible needed for a desired effect then when tolerance does knock at your door there is some room to up the dose to a max amount of 1,200 mg a day, prescribed that is.
Using a benzo together with lyrica is something you have to be careful with, because lyrica strongly potentiates benzo's so in case you have a benzo without getting much relief at te prescribed dose then adding lyrica can be quite benefical, but do not use lyrica with the intention to potentiate benzo's and/or other CNS meds. If you are used to taking say 5 mg diazepam three times a day then with lyrica once daily the diazepam would show to be sufficient, dont forget this.
Lyrica does work for certain people in higher then 600 mg a day doses so it could be worth it to see how 900 mg do if 600 mg were not very impressive. Something what also should be taken in account if lyrica is used together with other CNS depressants like in my case methadone and seroquel then if the lyrica goes you will also lose it's potentiating effect so its possible that a methadone dose taken before combined with lyrica will act a lot less strong without the lyrica, this is not the same as withdrawals. So far i wonder what happens when i hit 'post quick reply'.
Regards, Freek. ouchh that's half a book i wrote, excuse me.
 
Yes lyrica makes me soo talkative and is the perfect drug for social anxiety because it doesbt bring much sedation ans makes me rest really talkative which is something I love because most of the time I could care less to talk

does it cause memory loss and sedation? to which benzo could you compare its social anxiety relieving properties?
 
yes, lyrica can cause some memory loss and some sedation, but no where near the memory loss caused by benzos. if i were to compare pregabalin to a benzo, i would say alprazolam or lorazepam, but more close to xanax. the anxiolysis efficacy of lyrica is similar to alprazolam..but lyrica has the talk-a-tiveness effect that i love.
 
This talkative effect like you call it i know what you mean, but lyrica never worked like that for me. I suppose that the use of other substances with lyrica prevents such a feeling of being talkative when usually you aren't the same applies to me, but if you like the effect try to stick to twice weekly lyrica in the same dose, do not up the dose all the time, good luck.
Regards, Freek
 
Lyrica!!

Sup everyone, long time lurker here. I took a bunch of Lyrica last night(400mgs), felt great. Anyone have any experience with lyrica?
 
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