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Dissociatives The Little & Dandy MK-801 Thread

I don't know if "fun" is the word I think of when I read the report, lol. It does sound super interesting though.
The two reports I've read where users managed not to redose amidst the confusion, where they took less than 1mg, those people seemed to have like glowing L+ket experiences and thats my favorite combo.
Not only that but i imagine its super cost effective, 500mcg for a whole day vs at least 3 lines
 
Seems to be in manufacturing Phase and is announced for release in September 2022...

I'm interested!
 
I found some dizolcilpine analogs recently:

IDDC

Gee KR, Barmettler P, Rhodes MR, McBurney RN, Reddy NL, Hu LY, Cotter RE, Hamilton PN, Weber E, Keana JF. 10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands. J Med Chem. 1993 Jul 9;36(14):1938-46. doi: 10.1021/jm00066a002. PMID: 8101572.
Eckard Weber, John Keana, & Peter Barmettler, WO1990012575 (Oregon State Board of Higher Education, Oregon State).

I checked the synthesis and IDDC is made from 1,2-diphenylethylamine which is the same chemical used for Diphenidine synthesis.

FR115427
Nakanishi H, Katsuta K, Ueda Y, Takasugi H, Kuno A, Ohkubo M, Ogita K, Yoneda Y, Shirakawa K, Yoshida K. Behavioral studies on FR115427, a novel selective N-methyl-D-aspartate antagonist. Psychopharmacology (Berl). 1995 Jan;117(2):172-7. doi: 10.1007/BF02245184. PMID: 7753964.
Hisashi Takasugi, Atsushi Kuno, & Mitsuru Ohkubo, US5059608 (1991 to Fujisawa Pharmaceutical Co Ltd).
 
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I found some dizolcilpine analogs recently:

IDDC

Gee KR, Barmettler P, Rhodes MR, McBurney RN, Reddy NL, Hu LY, Cotter RE, Hamilton PN, Weber E, Keana JF. 10,5-(Iminomethano)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene and derivatives. Potent PCP receptor ligands. J Med Chem. 1993 Jul 9;36(14):1938-46. doi: 10.1021/jm00066a002. PMID: 8101572.
Eckard Weber, John Keana, & Peter Barmettler, WO1990012575 (Oregon State Board of Higher Education, Oregon State).

I checked the synthesis and IDDC is made from 1,2-diphenylethylamine which is the same chemical used for Diphenidine synthesis.

FR115427
Nakanishi H, Katsuta K, Ueda Y, Takasugi H, Kuno A, Ohkubo M, Ogita K, Yoneda Y, Shirakawa K, Yoshida K. Behavioral studies on FR115427, a novel selective N-methyl-D-aspartate antagonist. Psychopharmacology (Berl). 1995 Jan;117(2):172-7. doi: 10.1007/BF02245184. PMID: 7753964.
Hisashi Takasugi, Atsushi Kuno, & Mitsuru Ohkubo, US5059608 (1991 to Fujisawa Pharmaceutical Co Ltd).
The study "Convergent Strategy to Dizocilpine MK-801 and Derivatives" (doi:10.1021/acs.joc.8b00305) showed a synthesis route that is not only highly flexible, but could be approached in a cladestine context. I've been saying for a couple years now that this shit is going to be one of the next "fake acid" compounds sold on blotter. We're already seeing 5-MeO-MiPT, 5-MeO-AMT, DOx, 25X-NBXX, synthetic cannabinoids and other similarly potent compounds moving on blotter. I'm shocked that 3-HO-PCP hasn't been circulated on blotter yet, it's likely due to its poor solubility in compounds you could easily infuse into paper. 2C-B and methamphetamine moving in 10mg gel tabs is something else I've been shocked we haven't seen yet.

I hope people can figure out reagent tests for dizocilpine and its analogs sooner rather than later, as I suspect it will probably become an issue due to the intersection of greedy dealers and the war on drugs causing serious problems for well-intended drug users with dizocilpine and its various analogs. At the same time, I'm fascinated to see what comes out of the exploration of dizocilpine's analogs' SAR, and I hope that something fascinating comes out. In the meantime, I think I'll stick to arylcyclohexylamines, diarylethylamines, and dissociative morphinans though until the dizocilpine-like drugs are better studied, reported on and understood.

Edit: I wanted to mention that my issue with compounds with narrow therapeutic indices being placed on blotter is that blotter is insanely difficult to evenly produce. It would be significantly safer to work with gel tabs even, but I suspect that with the ease of shipping paper discretely, blotter will be the choice used by greedy dealers and traffickers.
 
The study "Convergent Strategy to Dizocilpine MK-801 and Derivatives" (doi:10.1021/acs.joc.8b00305) showed a synthesis route that is not only highly flexible, but could be approached in a cladestine context. I've been saying for a couple years now that this shit is going to be one of the next "fake acid" compounds sold on blotter. We're already seeing 5-MeO-MiPT, 5-MeO-AMT, DOx, 25X-NBXX, synthetic cannabinoids and other similarly potent compounds moving on blotter. I'm shocked that 3-HO-PCP hasn't been circulated on blotter yet, it's likely due to its poor solubility in compounds you could easily infuse into paper. 2C-B and methamphetamine moving in 10mg gel tabs is something else I've been shocked we haven't seen yet.
There is a certain vendor who has sold Meth, 2c-B and 3-ho-pcp agar gel tabs, so it is being done
 
There is a certain vendor who has sold Meth, 2c-B and 3-ho-pcp agar gel tabs, so it is being done
I'm familiar with this vendor and their agar tabs, I should've specified gel tabs by the sheet. That vendor moves tabs individually, if somebody ordered a hundred they'd receive a hundred loose, gnarled up little agar tablets. They look a little heinous but the vendor is reputable and I've communicated with them before, they really care about the quality of what they put out from what I can tell, I personally have consumed their 3-HO-PCP, Allylescaline, 25I-NBOMe and 25B-NBOH gel tabs. I'm more concerned about when somebody starts putting these in sheets of gel tabs that people assume to be, or knowingly falsely distributing "ketamine gel tabs" but it's 4mg of 3-HO-PCP and 50ug of LSD in each tab. Another one is how often mescaline is misrepresented, historical records of PCP and DOM being sold as mescaline make me wonder if somebody would ever make a green sheet of 15mg/tab gel tabs and try to sell them on the festival circuit. It's a pain in the ass to reagent test gels specifically due to the dye. Hell, moving sheets of meth gel tabs among college students would probably even be something that a money-hungry dealer would try.

In a way, I'm glad that your average greedy "hustle grindset" type of drug dealer isn't too bright about RoAs.
 
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