Miscellaneous The last days of MXE

[blistersinthedark]

PS : ket market is saturated ? I dont know were you live but here I cant find ket for years, like after the indian then chineese crash.

I suppose availability isn't the same in every part of the world, but just to give a sense of scale, China reported having seized 5.04 tons of ketamine in 2011 according to this WHO report (not going to hazard a guess as to how much actually finds its way to users, but it's probably more than that). The data is a bit old and the situation may have changed, but it's unlikely the current production of recreational dissociatives comes even close. I couldn't find a figure for how much ketamine is produced worldwide every year.

Ket is for me one of the worst arylcyclohexylamines

I have to agree. The main upside is how short-acting it is. When I tried MXiPr I finally "got" dissociatives. The warmth and euphoria completely blew ketamine out of the water. Too bad the batch that was (is?) circulating was so nasty-smelling.

 

[plumbus-nine]

Too bad the batch that was (is?) circulating was so nasty-smelling.

The sample I had seemed to be pure, white powder with little crystals and no smell. But it's prohibitively expensive and there are no discounts for higher amounts, need to wait some time I hope.

Yeah methoxetamines are warm and cuddly euphoric different but similarly strong than MDMA while 3-MeO-PCE was even hot not in a sexual but literal sense. My hunch is that there's an increase in metabolism, so actual warmth (not increase in body temperature though I hope) ... because ever since morphine lowered my metabolism and hormones I feel cold as long as it isn't 25+ degrees.

 

[G_Chem]

K is very common around here, I think the only time I haven’t been able to get some was a brief drought in 2017. Might have been purely down to my connects, otherwise it’s been smooth sailing. This last batch actually I can confidently say is the best K I’ve ever done too.

-GC

 

[Feretile]

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Missed the o-ketone!

The ketone increases the affinity to the NMDA receptor and the mu receptor. It also reduces the LogP of the compound and POSSIBLY reduces the DRI activity. That is the thing about MXE. it has 3 distinct pharmacological actions and balancing them is key. I suspect the N-methyl homologue would possess more opioid activity, and NMDA activity and of course a lower LogP so it will not be quite as potent. Should have a slightly shorter duration as we..

I have put the references on here somewhere. The QSAR of tiletamine derivatives including examples in which the cyclohexane is substituted for a4-thiane, the ketone is substituted for an alkyl side-chain and if memory serves, substitution of the thiophene ring. I think ring-substituted benzene (or possibly pyridine) rings are better. An o-OH (or it's i-OCH3 prodrug) will produce the most opioid activity when the amine is secondary (ideally N-methyl).

When MXE was designed,4-MeO PCP & 3-MeO PCP were tried first. They also resolved the enantiomers of ketamine to prove that one isomer was an NMDA antagonist, the other was a DRI. That done, I think MXE and whateve vendors called the 2-chloro-5-methoxy derivative of ketamine.

As for the diphenylethylamine class (diphenidine and so on), well it was the N-isopropyl that possessed the most NMDA activity (which is known for PCP analogues). The 2-chloro was not made simply for cost reasons. 2-methoxydiphenidine (methoxyphenidine) wasn't too good and was dangerous, from what I hear.

The papers expanded to 1,2-diarylethylamines so not JUST benzene rings but I cannot find much research on them. There was the original 1971 paper on the class followed by the 1996 patent and a couple of papers from 2005-2006.

https://www.researchgate.net/publication/24256957_NMDA_receptor_affinities_of_12-diphenylethylamine_and_1-12-diphenylethylpiperidine_enantiomers_and_of_related_compounds

The above shows WHY the 1,2-diphenylethyl scaffold is as active as the arylcyclohexylamine scaffold. Of course, finding the magic NMDA/Mu/DRI balance is really tricky.

 

[DeucerPro]

I never even considered 3-methylthio-2'-oxo-PCE before!!!

I've never seen a methylthio substituted arylcyclohexylamine yet, but why not?

What would you call it? Methioxetamine? MTXE?

I wonder how similar it would be.... We should lobby a lab to produce it.

Has Anyone tried anything remotely similar that’s an analog please do tell…

 

[Dr Mamba]

and a =N-ch3 instead of the ketone? you can try it at home if you got MXE or K.

 

[Feretile]

An imine? Imines aren't stable in water. You would end up back with a ketone and methylamine. Even if it were stable, it's too large and since it resonates, it would be bad for affinity.

Of course, the EJoMC proved that the ketone can be replaced by an alkyl moiety. Methyl was the best but of course that means an extra chiral centre. Complex, but proven to work.

 

[ecstacylover]

When I tried MXiPr I finally "got" dissociatives. The warmth and euphoria completely blew ketamine out of the water. Too bad the batch that was (is?) circulating was so nasty-smelling.

Yeah the first batch was a white powder but it did have a very odd smell. I've seen pictures of more recent batches and they're a brown powder which I find a bit more concerning. I noticed the same thing with pics I saw of the recent MXPr (it was a brown powder, whereas the batch I had back in 2019 was white).

Seems they've just gotten lazy with purifying their products.

 

[Dr Mamba]

it have nothing to do in a MXE tread, but stability of imines can be a + on the legal point of vew.
and k is almost instant nasaly, so degradation ... worth an easy try ( perhaps with K for a bigining)
and if it have 2 nitogenes like tryptamine, perhaps those imines could be "sabilized" as fumarate, precipitate in a non aquus solvant.
(now english language is dead for sur )

 

[ecstacylover]

I would say no. If it was gonna return, it would have already happened... I'm fairly convinced there are global conspiratorial forces at work to keep it that way too. They don't want the people to have it... but why? It must be a threat to the furtherance of globalist elites' interests.

Sooo MXE-gate basically? Anyone who says otherwise is compromised!

 

[impossiblephoto123]

K is very common around here, I think the only time I haven’t been able to get some was a brief drought in 2017. Might have been purely down to my connects, otherwise it’s been smooth sailing. This last batch actually I can confidently say is the best K I’ve ever done too.

-GC

Hi! I'm Dave..

I'm in my mid 50's now, and discovered roughly 10 years ago, the amazing therapeutic capacity of K for my particular issues (severe PTSD, Depression, and generalized Anxiety disorder) which ultimately drove me into a serious drug fueled tailspin around 2010.

I was primarily using enormous amounts of cocaine combined with a variety of prescribed opiates, which (when I failed a piss test at my docs), drove me ultimately to heroin. Although I never went IV, smoking rock and using a bundle or more a day

I love in NJ, and for many years had a very reliable connection

 

[LucidSDreamr]

One memento I'd like the share is that the last time I ever did MXE during the endtimes of the drug....was on my wedding night.

Just a functional dose to dance the night away with some Xanax and alcohol added in.

It was a fitting end to my love affair with my #1 favorite drug of all time and the drug that did the most damage to my life (more than crack and IV opioids).

It was a lovely dose. And a magical night all around with non drug natural euphoria of getting married capped off with one last fling with my side bitch MXE

 

[impossiblephoto123]

I found a similar experience separated me from my need for the specific drugs I was using at the time.

For me, understanding the specific difference between what we see and experience IRL and what our actual purpose, was THE thing that made Ket special and important.. for me anyway.

I've literally experienced the end of my life both in real life, and multiple times under an anesthetic, (like ketamine) ultimately both nearly identical.

It took me several years to understand the similarities and the differences. (At least a decade to realize). The reality is, IMHO, that we (those that have experienced a "k-hole" that took us OUT, and then returned us to present) already know what the end is and understand why.

It's nearly impossible to explain what this experience is. Our "English" language is insufficient, but it has 4 specific points relating to our perceived "self", that have to do with the beginning and end of ones "ego" then the complete loss of it all, and the return to our present understanding of our "Ego"), (**See Maslowe and B.F. Skinner)

We return to the beginning of our objective "re-experience" of our most potent experiences of life, and then we transition to the ultimate reconciliation and acceptance of those "realities" and then differentiate between those experiences and the way we realize (re-view) those experiences.

Our individual view of these things happens only when we experience them in our individual reality.

I've been seeking a method, a chemical, an understanding of "why" and "to what end" or purpose we do what we do, to then understand and communicate this.

I'm sure what I'm saying comes across as madness to most, particularly ones who've never had this experience.

To some, there is an understanding.

Eventually those of us who understand the end/beginning might be an understandable experience to those who have taken this risk.

I hope so anyway...

I would love to hear from anyone who understands what I am talking about. I may be mad. I may be sane. If you've had a similar experience, I would love to hear from you .

 

[unodelacosa]

Has Anyone tried anything remotely similar that’s an analog please do tell…

I'm a fan of 3-HO-PCP. It has a mild affinity for the µ-opioid receptor ~halfway b/t codeine and hydrocodone whilst still providing a complex and trippy dissociative state. Sometimes I blend-in cocaine and/or ketamine which is close to replicating the effects of MXE, which to me is a euphoric disso with a mood-boosting pro-social aspect to it, and a pronounced anxiolysis. Because it's easy to re-dose, there is some danger w/ this drug regarding those with compulsive behavior pattern disorder.

A close 2nd place, for me anyway, is 3-MeO-PCP but it progressively gets more and more manic from there → 3-HO-PCE → 3-MeO-PCE.

Honorable mentions go to diphenidine and 3-CL-PCP (which can only be ingested, not insufflated without great pain, but its effect are very close to Ketamine with a longer duration and a bit more mobility if dosed properly).

I may be mad. I may be sane.

Isn't this a Billy Joel song? "You may be right. / I may be crazy. / But it just may be a lunatic you're looking for."

those [who] have experienced a "k-hole"

Definitely. And then there's the peak experience at a sufficiently high dose of MXE called an "M-Hole", right? Those who have experienced it know what I'm talking about.

So then in an analogous-manner, PCP has a peak experience, but what do you call it then, a "P-Hole"? That doesn't sound right. “Oh shit, bro, I'm stuck in a P-Hole.” That's no bueno.

 

[impossiblephoto123]

Classic! . I always hated the whole "Hole" reference personally, but... Since we're on the "hole-roll". I once smoked so many cigarettes my friends could have called me a butt-hole.

To many K-Holes will almost certainly lead to trouble with your P-Hole!

 

[FuckinAcidMan]

tbh 3meo PCP was better than MXE kinda.

i think a large part of MXE's nostalgia is that it was the first STRONG dissociative a lot of us tried, cause tbh ketamine ain't shit unless you ready to fuck with needles, which is a big nah for most people.

 

[Mjäll]

I'm a fan of 3-HO-PCP. It has a mild affinity for the µ-opioid receptor ~halfway b/t codeine and hydrocodone whilst still providing a complex and trippy dissociative state. Sometimes I blend-in cocaine and/or ketamine which is close to replicating the effects of MXE, which to me is a euphoric disso with a mood-boosting pro-social aspect to it, and a pronounced anxiolysis. Because it's easy to re-dose, there is some danger w/ this drug regarding those with compulsive behavior pattern disorder.

A close 2nd place, for me anyway, is 3-MeO-PCP but it progressively gets more and more manic from there → 3-HO-PCE → 3-MeO-PCE.

Honorable mentions go to diphenidine and 3-CL-PCP (which can only be ingested, not insufflated without great pain, but its effect are very close to Ketamine with a longer duration and a bit more mobility if dosed properly).


Isn't this a Billy Joel song? "You may be right. / I may be crazy. / But it just may be a lunatic you're looking for."

Definitely. And then there's the peak experience at a sufficiently high dose of MXE called an "M-Hole", right? Those who have experienced it know what I'm talking about.

So then in an analogous-manner, PCP has a peak experience, but what do you call it then, a "P-Hole"? That doesn't sound right. “Oh shit, bro, I'm stuck in a P-Hole.” That's no bueno.

I think it may be called "stuck", plain and simple. That slang term was in a few erowid PCP experience reports.

So the PCP equivalent of "being in a K-hole" is "being stuck" or "being stuck on PCP".

Automaton, robot vibes like the whole mythos around PCP.

 

[unodelacosa]

I think it may be called "stuck", plain and simple. That slang term was in a few erowid PCP experience reports.

So the PCP equivalent of "being in a K-hole" is "being stuck" or "being stuck on PCP".

Automaton, robot vibes like the whole mythos around PCP.

It was a joke, lol; I assume no one actually says p-hole, mostly because it’s a funny homonym for the slang term for a urethra. Regardless, thanks for the clarification

Shiiiiiit, the times I’ve been stuck on PCP I was in no shape to articulate that fact or much of anything to anyone, never mind double entendres. My mind was lost in cosmic apotheosis. I was in that pee-hole, son!

Haha, on the reals I’ve heard “stuck in a hole”, “stuck in a pcp-hole”, “sherminated”, “dusted”, and “being on The Loooove Boooooat!” (in Washington, DC anyway). There’s an Alice In Chains song, “Down In A Hole” but that’s about something different.

• At a certain threshold on 5-MeO-DiPT—aka “Foxy Methoxy”—one could say they were “in a fox-hole”…
• Or at a certain level of cocaine you might be “in a blow-hole”
• If using Afghan #4, at some point that could be “a mud-hole”
• I suppose Cannabis can put someone “in a pot-hole”
• If you took MDMA w/Molly Ringwald while listening to Molly Hatchet but visually watching the film, Johnny Mnemonic, you could be “in a Molly Ringwald Molly Millions Cock-Ring Ratchet-Hole”*

* (which, incidentally, is the name of my third band—I played a key-tar and we had a kazoo section and we mostly did psychedelic death metal covers of Christmas anthems; we were not popular and it was all very confusing, like being in a pee-hole, or being in a p-hole. Which, in a sense, anyway, is the equivalent of being in a man-hole. Clear as mud? … Selah.)

 

[phenethylo J]

Miss being able easily get it. Have to be conservative with the tiny bit I have left; no more snorting eye balled lines in public rest rooms to kill the time when I'm going shopping.

Had a nice experience plugging 7mgs near the end of January. Think it def helped me through my month long thc break that I started a few days later.
Saving the rest to mix with some 2c-b and 2c-p. Used to like plugging and snorting multiple small doses of mxe+2c-b and/or 2c-p throughout the day. I made sure to be really careful when redosing to 2c-p.

 

[TMNPothead]

Gave me two separate manic episodes where I stripped my clothes and tried to fight someone. Don’t remember a thing. This from snorting maybe 60mg tops. I’d say I was aiming for 30-40mg and I don’t know why but these episodes lasted around 6 hours. I’ll never touch the stuff again, most out of my mind I’ve ever been. And that’s coming from a person who dropped 4mg of 25iNBOMe at the tail end of a 3 day long APVP binge of around 7 grams between 3 people. I was already seeing shit before the NBOMe and continued to hit the APVP while the come up started. Saw my bearded dragon literally start floating around it’s cage and decided I probably need to calm down