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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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I think aminorex is an interesting stimulant phenethylamine because of the absence of the a-methyl group that's necessary in phenethylamine vs. amphetamine but not in aminorex vs. 4-mar. Instead it has some cyclicized complex at b- and n- or whatever.

So EEwanko I think there could be some b-substituted phenethylamine that have strong central action, perhaps b-methoxy phenethylamine or something? I'm also interested.

And no nuke he wasn't asking about fucking amphetamines! he was clearly asking about b-substituted phenethylamines, not substituted anywhere but substituted at R-b.
 
lool, ok i relaise i jave to be really specific when questioning. thanks guys, n erm... just to clarify for future reference i am a she :P. so to rephrase, how many chenistry based studies have their been conducted on the synthesis of beta substituted phenylethylamines with both forms (d-Ephedrine & n-Ethylcathinone ), and how successfully are their analogs detected by GCMS
 
chloral hydrate said:
And no nuke he wasn't asking about fucking amphetamines! he was clearly asking about b-substituted phenethylamines, not substituted anywhere but substituted at R-b.
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Those are selective NE releasers. Sometimes things look wonky when merged.

Beta-substituted phenethylamines... The cathinones are stimulants similar to amphetamines, the ephedrines are mostly active NE releasers/reuptake inhibitors, and the beta-ether compounds were problematic from a physical standpoint in PiHKAL. I don't know much else about them. They're fairly easily detectable by GC/MS, like most small compounds.
 
Hi guys, first post here - please be kind :)

Is it possible that the CNS effect of oxymetazoline has been underestimated? Descriptions claim a negligible stimulating effect, and possible depression of CNS in children - but I've always felt a much more noticeable effect from this seamingly benign medicine.

It seems that whenever I use it I'm more choleric, assertive and overconfident - without it I'm more mellow, thoughtful and a bit indecisive.

And this is a "fair" comparison since I've spent 14 years of my life being addicted to this thing (2-3 times daily), with on and off periods. These effects are very consistent.

I'd appreciate your opinion on this :)
 
Can anyone find a source for wiki's claim that citicoline is a stimulant, or any studies of it being used in normal, healthy people?
 
nope.

on the matter or oxymetazoline- very unlikely. It's similar to clonidine, I guess.

I would wonder if it had a plain phenyl ring instead of all that cabbage if it would be stimulating. I suspect that it'll be too much like clonidine regardless, though.
 
Hammilton, thanks for your reply!

It confuses me a bit though - isn't Clonidine an a2 agonist? And Oxymetazoline mostly a1?
 
Will someone please explain the pharmacological effects of a dopamine disinhibitor?
 
Will someone please explain the pharmacological effects of a dopamine disinhibitor?
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The antagonism of any downstream inhibitor of dopamine release, eg 5HT2C antagonism or 5HT1A agonism. Mirtazapine being a good example.
 
Quick question

What program do you guys use to draw all of these molecules? Or do you just use MS Paint or something similar?
 
chemdraw usually, however there are loads of free chemical drawing programs which are as good.
 
I have Chemsketch, which is free but annoying as hell because it keeps telling me how much better it would be if I would purchase the parent program. I wish there were a biochem program where you could craft a molecule and administer it to an organism of your choice and have the program work out the effects viz binding sites and ADME kinetics.
 
I've never had a problem with chemsketch, though I haven't honestly used it much.

Anyway, I'm a chem major who currently in Organic I, just finishing up reactions of alkenes and alkynes, and I'm trying to start learning basic pharmacology, and my school doesn't seem to offer anything of the sort, with the exception of forensic toxicology (?). I've found some good info (I haven't taken a full look yet, though) on MIT's open course website, but I'm curious as to if there are any sources that you guys recommend?

Thanks
 
Enkidu said:
Are those autoreceptors?
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Well, probably not. It depends on the neurons themselves.

Serotonin Receptors

There is a paucity of information on the direct electrophysiological effects of serotonin on central DA neurons, and there is a similar lack of anatomical data suggesting the presence of serotonin receptors on DA neurons. There are over a dozen serotonin receptors (the rate at which new ones are cloned suggests that it is prudent not to specify an exact number), some of which are present only in certain species (see Serotonin Receptor Subtypes and Ligands). 5-HT2c (previously designated 5-HT1c) receptor transcripts are present in cells of the pars compacta, suggestive of colocalization in the A9 DA neurons. However, Chesselet and colleagues (19) have found that those pars compacta cells that express 5-HT2c mRNA are exclusively nondopaminergic.
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http://www.acnp.org/g4/GN401000018/CH018.html

Check out this paper: http://www.jpp.krakow.pl/journal/archive/0608/pdf/229_0608_article.pdf

So it appears to be indirectly through GABA or glutamate or some other messenger.
 
1. What substances provide mental stimulation with minimal physical stimulation? Or alternatively, what can block the physical component of stimulants?

2. Why aren't substances like Bromantane more widely available?
 
Opiates and immune system.

I have read that opiates suppress immune system. Do it means, that if i get flu and will start to use codeine for easying symptoms it will prolong time of cure?
 
Mephedrone in the freezer?

Hi,

I was wondering what would be the best way to keep mephedrone (probably in a freezer I guess) and how long I could preserve it. Thanks in advance.

Greetings,

Gio
 
You could keep it out of the freezer and it'd probably be stable for an excessively long time. The only instability is the secondary amine causing dimerization with the carbonyl function group, but it's probably very stable as a dry powder salt kept away from moisture.
 
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