FlawedByDesign
Bluelighter
Just curious if anyone has heard about the $5 million kratom seizure in California:
www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm416318.htm
Fuck me

Fuck Da F.D.A.
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Just curious if anyone has heard about the $5 million kratom seizure in California:
www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm416318.htm
Berdo, have you considered you may have gotten sick independent of the kratom? Kratom shouldn't cause week long flu type symptoms, the half life of mitragynine & the other chemicals is rather short.
But arent the flu symptoms from depleted opiod transmitters? just like how mdma you feel most like shit only once its OUT of your system hence the term suicide tuesdays.
Opioids don't cause your body to "deplete opioid transmitters" - they don't cause release of endogenous opioid peptides, they actually act at the opioid receptors themselves, if anything it's a simple rebound effect, like the aftermath of a LSD/mushroom trip.
Kratom is a norepinephrine releaser because it works as an antagonist as a2a/a2c adrenergic autoreceptors, like yohimbine. This is why it's stimulating in lower doses (below where mitragynine activates the mu opioid receptor). That's probably why it keeps you awake. Drugs that are the opposite - a2a/a2c receptor agonists, are powerful sedatives and antihypertensives like clonidine.
Kratom use probably also elevates blood pressure a little. In combination with caffeine it could cause hypertension.
Hmm this doesnt seem so good as an anti depressant after all. did antoher trial this week and 1st dose of the week worked good; good mood lift and all with little ill effects but then tried again on friday (tuesday was first) and couldnt catch hardly any euphoira dispite taking 3 grams vs 2 on tuesday, and got the flu symptoms coming back again and couldnt sleep well last nightso it does seem pretty conclusive now its the kraom that causes these flu symptoms for me.
Once every so often isnt pretty pointless. Unless Im thinking i could find other substances to jump from one to the other to cover me through most days of the week, with maybe a couple off. but Ive run out of 'natural' stuff now so eitehr i venture into the no mans land of research chemicals or jump on the mainstram bandwagon of anti depressants or majically find the root cause of my depression and all my issues will vanish. Then agina there is ol' meditaiton and excercise which is a cure all panacea for everything as everyone says, now if only i had thought of that; how simple thanks chief im cured.
Seems Im going to have to degrade my morals now of using drugs tested on animals to try and get some releif from this brain crippling malady.