RCs The GHB + Phenibut Love Child: 4-Hydroxy-3-Phenylbutyric acid (PHB)

[TrumpetingEcstacy]

This became available about 3 months ago and there still seems to be very little information about it. This chem is just phenibut with the amine group replaced with an alcohol OR GHB with a phenyl ring on the 3rd carbon, however you want to look at it. My chemistry/pharmacology knowledge is minimal but wouldn't the addition of the phenyl ring on GHB make it cross the BBB better? After all, this is the case when you add the phenyl ring to GABA (i.e phenibut).

When I posted about this on reddit right when the compound became available there was some speculation that this compound could lead to problems. Apparently if the GHB receptor is activated without also activating GABA-b (as is the case with GHB) this is very excitatory and can lead to seizures. However, the vendor claims that it does in fact also activate GABA-b (for what thats worth lol).

Now I have done a bit of experimentation with this compound myself but it has so far produced no effects. I started with a dose of 1mg and cautiously worked my way up to 100mg but so far nothing.

Does anyone here have any experience with this compound? I absolutely love both phenibut and GHB so I feel like this compound should should be a winner but I am kind of afraid to push the dosage.

 

[boothby]

I partly came to bluelight to seek information regarding this substance. (It is marketed here as being 50-100 times more potent than Phenibut). Is there any other discussion regarding this substance? @TrumpetingEcstacy did you continue your assay?

 

[Dextro .45]

I have access to purchase this compound in Canadian, but……meh ?

4-MMC seems very appealing DET>SERT binding comparable to d-desoxyephedrine in a medical journal study

4-MMC (Khat analog)
d-Methamphetamine
MDMA

Interesting read..you can google it and read the study

 

[Deleted member 563132]

this is of particular interest to me, im going to look around for reports

 

[emkee_reinvented]

Is there no research or way to use Phenibut/ GHB pharmacology.
On this compound ? And the hypothesis it could possible activate.
Why would it only activate the GHB receptor,
any clue where that idea is based on ?

Without being pharmacological wise, afaik GHB activates both.
Take a lot a GHB you fall a sleep by GABA-b activation.
Why its in us for Narcolepsy. This pharmacology is on the net.

As blood levels drop the GHB receptor is mainly stimulated.
Explaining the sudden wake up 3.5/ 4.5 hours later.
Why Narcoleptic s are prescribed 2 doses a night.

Phenibut, beside reading its perfect as tool to WD from GHB.
The state it created not something i find worth replicating.
Don t no if it only work s on GABA-b, and not GHB receptor s.
But i think so, what other action it has ? It felt miserable.

Not even close to GHB.

 

[Deleted member 563132]

As blood levels drop the GHB receptor is mainly stimulated.
Explaining the sudden wake up 3.5/ 4.5 hours later.
Why Narcoleptic s are prescribed 2 doses a night.

veeery interesting

Not even close to GHB.

damn. too bad

 

[emkee_reinvented]

veeery interesting

It was called the Dopamine surge in the beginning of internet.
Which was in-correct. Like the claim it was non addictive.

And non neuro-toxic, while sudden dis-continuation when physically addicted is.
Interesting, and even now hearing addiction addict s say it so addicting.
Imo not such a big deal compared to Kratom or the worst Alcohol.

And they have no clue to help all these young people addicted.
While Xyrem is prescription pharmaceutical GHB, they can use.
In combination with a inpatient detox.

If i can figure that out and addiction dr. can t. are you worth being.

 

[General alcazar]

GHB was amazing. I wish I had ordered the 55 gallon drum before GBL became illegal. I only ordered 6 gallons and that ran out a long time ago. GHB definitely had a rebound at 4 hours, but I had a second shot of 5 mg GBL in orange juice by my bed to knock out when I woke up. GBL was magic. I miss it so much. There’s nothing like it. I slept so well until I ran out. Since then, I was benzo dependent, and when those ran out, and alcoholic. Needless to say, not an improvement. Oh well…