The End All Be All Benzedrex - Addreall Equivanlency Thread

[lyricabuddy]

Just wanted to post this for future searches. There is little to-no info on equivalences for benzedrex. Long-time lurker proxi 2005. I say 1 cotton = 40mg XR. Anyone else feel free to contribute.

 

[modocmodoc]

Look up Barbexiclone. Not used in the US, but very widely used across the world, there's very complete information on PK/PD, etc. (phenobarbital + propylhexedrine) .

It was supposedly used as an appetite suppressant and as an antidepressant in Russia, but I've never found documentation that satisfied these claims. There may be something out there because I was working on a research paper.

At any rate there is long-standing proof of the good safety profile of PPX (used to offset phenobarbital sedation in a first line antiseizure drug? that's safe). This has been an annoyance for a long time, where people claim that PPX causes all kinds of irreversible damage or whatever. It's bullshit; oral PPX is quite safe. However, the dosages in Barbexiclone (close to 50% of 25-100mg tablets) and those purportedly as an appetite suppressant (~50-100mg/dose) are nowhere near the recreational doses used here. It apparently was used mainly for adolescents and older children, but not adults.

 

[BurritoJimmy]

Look up Barbexiclone. Not used in the US, but very widely used across the world, there's very complete information on PK/PD, etc. (phenobarbital + propylhexedrine) .

It was supposedly used as an appetite suppressant and as an antidepressant in Russia, but I've never found documentation that satisfied these claims. There may be something out there because I was working on a research paper.

At any rate there is long-standing proof of the good safety profile of PPX (used to offset phenobarbital sedation in a first line antiseizure drug? that's safe). This has been an annoyance for a long time, where people claim that PPX causes all kinds of irreversible damage or whatever. It's bullshit; oral PPX is quite safe. However, the dosages in Barbexiclone (close to 50% of 25-100mg tablets) and those purportedly as an appetite suppressant (~50-100mg/dose) are nowhere near the recreational doses used here. It apparently was used mainly for adolescents and older children, but not adults.

What are the dosages people would use on this? I can't imagine people taking the equivalent of 200mg PPX everyday and not having terrible side effects.

 

[modocmodoc]

For barbexiclone, my rough guess is 25-100mg bid, and I believe drugbank lists PPX as 40% by weight to 60% phenobarbital, so we're really talking about a maximum dose of 80mg, HOWEVER I have not seen literature that indicated that it was ever used in adults as a first-line, so perhaps an adult weight of, say 60Kg would be double that.

Still nothing compared to the inhaler dosage, but I'm not sure how well absorbed that is. I'm going to guess it's pretty high, though ... a free base converted to a hydrochloride in the stomach, anyway. Preconverted to acetate or citrate you're going to lose quite a bit because of the volatility of it, but then you probably are going to use two inhalers to start with so I think that's 500mg, assuming you lose half of it (which is ridiculous but bear with me) you still get a whopping dose of 250.

(Realistically I bet you lose at most 90% if you don't leave the shit lying out before you do the conversion, so don't use two inhalers, and for HR, start with one).

What are the dosages people would use on this? I can't imagine people taking the equivalent of 200mg PPX everyday and not having terrible side effects.