I started taking fluoxetine 20mg/day 14 weeks ago. I stopped taking them on Monday 24th June.
I haven't discussed it with my GP, I just stopped, because I am a risk-taker. I feel fine so far. Should I be scared?
Presuming I still feel fine on Friday 6th July (my Birthday), will I be OK taking serotonergic drugs?
If you feel fine, then that is all that matters. No reason to be scared. You can find half life or time to eliminate information of antidepressants online. I researched this subject extensively as I was considering taking tramadol whilst on an SSRI and needed to calculate the risks. I would imagine that after 2 weeks 100 % of most antidepressants will be totally eliminated from your brain and nervous system. However the half life of antidepressants varies significantly, and I think Fluoxetine has the longest halflife of them all.
Pretty complicated information on wikipedia:
The extremely slow elimination of fluoxetine and its active metabolite norfluoxetine from the body distinguishes it from other antidepressants. With time, fluoxetine and norfluoxetine inhibit their own metabolism, so fluoxetine elimination half-life changes from 1 to 3 days, after a single dose, to 4 to 6 days, after long-term use. Similarly, the half-life of norfluoxetine is longer (16 days) after long-term use.[2][47][48] Therefore, the concentration of the drug and its active metabolite in the blood continues to grow through the first few weeks of treatment, and their steady concentration in the blood is achieved only after four weeks.[49][50] Moreover, the brain concentration of fluoxetine and its metabolites keeps increasing through at least the first five weeks of treatment.[51] That means that the full benefits of the current dose a patient receives are not realized for at least a month since its initiation. For example, in one 6-week study, the median time to achieving consistent response was 29 days.[49] Likewise, complete excretion of the drug may take several weeks. During the first week after the treatment discontinuation, the brain concentration of fluoxetine decreases only by 50%,[51] The blood level of norfluoxetine 4 weeks after the treatment discontinuation is about 80% of the level registered by the end of the first treatment week, and 7 weeks after the discontinuation norfluoxetine is still detectable in the blood.[47]
CBA wading through that, but i would imagine there would be very minimal chances of dangerous interactions 2 weeks after stopping. I have taken MDMA,Methylone and MDAI after 24 hrs without Sertraline, and tramadol 48 hrs after, with no adverse effects. This is not to be recommended but I didnt have any bad reactions, although there was still enough of the SSRI in my system to block the serotonin receptors and prevent MDMA and Methylone working very well. I should point out that Sertraline has a far shorter half life than Fluoxetine. From memory, Sertraline is about 75% eliminated after 48 hrs.