Not untried by me, I've been working my way through the best part of two grams over the last month or so. I been combining it with mxe, mxe + methoxydiphenidine (that really does give you crazy psychological distortions), but I'm not just flipping a coin. I feel that it will lower the hearrt rate, however, at high doses - above 200mg for me as I have a tolerance it could be very risky in terms of depressing breathing. That's why I went with a nice and conservative dose of 80mg. I regularly take 150 mg along with all sorrs of other stuff so I do have some experience, though i am far from being confident. it just seems like the only thing I have in my arsenal right now that makes sense, aside from a trip to the shop for a pack of smokes.