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The Big & Dandy Worst Psychedelics thread

This is actually a strangely interesting subject to me. I like to read about the most toxic/negative psychoactives when I'm perusing the vaults of Erowid :)

Here's a list of some of the worst ones I've found:

Mescal beans, ergot, BZ, datura, mandrake, henbane, MPTP, PMA, sinicuichi, jenkem (lol), hemlock, 3C-P, and carbogen, which is known as a "panicogen" (induces panic).

Most of these are somewhat psychoactive, but are better known for their poisonous/extremely negative effects. Of course everybody has their own personal "worst", but these are the kind that can kill.

My personal worsts are diphenhydramine, alcohol, tricyclic antidepressants, salvia, cyclobenzaprine, doxylamine succinate, and propoxyphene.
 
I hardly think alcohol is the least-enjoyable drug effects wise - not to mention the fact that it isn't a psychedelic - though I guess there has yet to be another substance that left me passed out in a ditch, covered in my own piss.

DPH (Nytol + Pseudoephedrine to keep me awake) was the most appalling thing I've ever experienced.
 
DXM, :!
Arggh, good god never seen how anyone can like it, Not ragging on those of you that do, but I guess I'm just mad cause I cant enjoy it. Delerients to me arnt that bad,
I'd like a few trips of Diphen every know and then.
 
CRUNKERthanU said:
Yep 5-meo-dipt is pretty awful. Not useful at all. Chills, shivers, upset stomach, anxious, uncomfortable, no good feeling at all, only visuals purple outlines.
ABSOLUTELY SUCKS
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Sounds like you took too much. Are you on any regular meds?


As for me?
I think Ecstasy is terrible. Not worth the aftermath e-tardedness. It feels fake to me. I know none of what I'm feeling is real, and that its only a chemical, and makes it hard to enjoy.
Tryptamines, for me, have a smooth synergy to them. Fungus and toad venom are great fun.
 
Interesting thread, I was wondering if anyone has any experience of combining some of these "bad" drugs with something like LSD that would amplify the negative effects? Would the LSD overpower the bad effects? I imagine combining it with some of the panic inducing chemicals would be particularly unpleasant...
 
Did someone say "ergot" is a bad drug?? Isn't that like, where lsd comes from?

Well from my experience in drugs, which is only Weed, Alcohol, Shrooms, Lsd, Nitrous, DXM, MDMA.

I had a second plateau DXM trip, and I was fucking projectile vomiting the oranges I had that morning all over the fucking bathroom, there was nothing special about a 2nd plateau trip at all, except that I was vomiting all over, but I would like to try a 3rd plateau.

DXM Just sort of made me feel warm and have a sence of well-being- With lots of throwing up.
 
LabRatNW said:
As for me?
I think Ecstasy is terrible. Not worth the aftermath e-tardedness. It feels fake to me. I know none of what I'm feeling is real, and that its only a chemical, and makes it hard to enjoy.
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Agreed... I hate MDMA. AMT is similar in nature but is tremendously better. MDMA feels so fake and forced, and the aftermath is sickening. And its method of neurotoxicity has been established at this point. It's not quite as bad for you as meth, but it's not good.

The Winner!! said:
Did someone say "ergot" is a bad drug?? Isn't that like, where lsd comes from?
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Sort of... well, it could come from ergot, as ergot contains a substance that it's possible to begin synthesizing LSD from. But if you take ergot your limbs can fall off from vasoconstriction. People used to rub up against it in fields and die.
 
tittysnacks74 said:
You should be banned for recommending CCC to anyone.

Coricidin Couch and Cold also contains Chlorpheniramine Maleate (CPM) as an active ingredient along with DXM. Taken in high doses equivalent to the DXM high that accompanies it, CPM can cause bleeding from the eyes, coma, and death.

Never, ever, ever take CCC. Good-ol-robitussin does the job just fine and will not kill you in reasonable doses.
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Alright, first of all, I know what is in Coricidin and I have taken it in doses far above what should ever be taken. I have taken two boxes of Coricidin at time, a plethora of times, and have had no ill side effects. That is 128mg of chlorpheniramine maleate compared to the normal 4mg per suggested therapeutic dose.

I realize the effects it can have on one's body and I am in no way suggesting that someone use it in this amount or anywhere near that. When I had taken it in those amounts, I was not aware of the health risks it had.

There is, however, a noticeable difference in the feeling of Coricidin and the feeling of Robitussin cough gels or syrup. I suggested only 8 pills of Coricidin and ONLY on the first time. I find that it has an increased effect on tactile sensation and produces less nausea in comparison to gels or syrup.

Taking DXM products that contain chlorpheniramine may be a bad idea even the first time for certain individuals, but I doubt that it would result in serious health injury at doses that low and I have certainly never heard of any reports suggesting otherwise.

To make this less of an issue, I retract my previous statement and do not condone the use of products that are not DXM-only.
 
Xorkoth said:
Agreed... I hate MDMA. AMT is similar in nature but is tremendously better. MDMA feels so fake and forced, and the aftermath is sickening. And its method of neurotoxicity has been established at this point. It's not quite as bad for you as meth, but it's not good.



Sort of... well, it could come from ergot, as ergot contains a substance that it's possible to begin synthesizing LSD from. But if you take ergot your limbs can fall off from vasoconstriction. People used to rub up against it in fields and die.
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Slightly offtopic: I always thought MDMA was more neurotoxic, since its serotonin/dopame release ratio is higher than meth. Although less potent, that's compensated with higher dosages. MDMA even has oxidative metabolites, which meth lacks iirc. Although I use neither of them, I try to understand their toxicity profile, so could you please explain why MDMA is less neurotoxic than meth (except for duration)?
 
I heard this over in ADD at some point if I recall correctly... I would find it easy to believe that MDMA is more neurotoxic, based on perceived aftereffects.
 
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Pentazocine - acts at same receptor as salvinorin A (among others), so I suppose sort of on the fringe of being psychedelic - any drug that results in you getting lost in your own house merely because you turned through 180' has to be pretty ugly for most

Of the 'true' (ie serotonogic) psychedelics, my vote goes for 5-methoxyAMT as it opens the sluice gates at both ends of the digestive system. Actually, most 5-methoxytryptamines IMO
 
The Winner!! said:
Did someone say "ergot" is a bad drug?? Isn't that like, where lsd comes from?
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Yeah, it is the major source for ergotamine tartrate, the buiding block for LSD....but ergot itself contains many many different ergolines which are incredibly toxic.

Anyone tried Scopolamine?
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Yep. Its fucking awful. 2 days of craziness- plus its actually really really boring and repeptitive :\ Also, incredibly dangerous....

I'd have to say, cannabis can certainly be a pretty negative experience. I've been smoking a bit again, and each time I just feel sordid, guilty, really low self-worth reckoning....that said, I recently quit an enormous habit and kinda made myself feel bad because I was aware I shouldn't be smoking....but yeah, cannabis can certainly fuck with one in a very unpleasant way.

On that note, I've quit again, and learned something too.
 
tribalDJ said:
Interesting thread, I was wondering if anyone has any experience of combining some of these "bad" drugs with something like LSD that would amplify the negative effects? Would the LSD overpower the bad effects? I imagine combining it with some of the panic inducing chemicals would be particularly unpleasant...
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the bad will overpower the good, most likely

like in an orchestra of many musicians. if one fucks up, it's all wrong
 
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