mozokev
Bluelighter
- Joined
- Feb 15, 2012
- Messages
- 77
Hasn't anyone bothered to look at Ralf Heim's dissertation? (Ralf Heim = RH!) OK, it is in German, but the tables are easy to read. RH-34 is a low affinity agonist at 5HT-2a receptors, about 20% that of 2C-B, so based on that it shouldn't be active until about 80-100 mg. Nevertheless, a proper titration is in order. What was interesting about RH-34, of course, is that the 2-methoxybenzyl group made an antagonist (Ketanserin) into an agonist. This led to the preparation of the N-BOMe derivatives of the 2C-Xs, and the rest is history.
Affinity does not equal active dosage, if I'm correct. Perfect example is LSD vs. NBOMe's. LSD has lower affinity for 5HT-2A receptors than NBOMe's but is more potent dose wise.