Dissociatives The Big & Dandy PCP Thread

[MedicinalUser247]

Well... I'm just wondering why there's such a difference between the effects of Dissociatives ? Besides PCP and Ketamine, which I like. There's nasty Dissociatives such as DXM. And then there's ones that make you feel like your in Heaven such as Nitrous Oxide. They all effect the NMDA receptors, But they all feel so different. Why would that be ?

 

[cosmic charlie]

Im assuming its differences in the binding affinities at the NDMA receptor and also what other receptors they hit has well. Not all dissos only hit the NMDA receptor only many a number of them play around with Seratonin like MXE and family. PCP releases dopamine and other stuff as well. DXM is a stronger SSRI than a disso and just a really gross drug honestly, very dangerous in combo with alot of stuff. Horrible bodyload, its the worse disso in my opinion.