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The Big & Dandy 'Nausea and Psychedelics' Thread

2C-I is not really that bad IMO as far as insufflation of a typical lower level dose. Like all phens it makes my stomach uncomfortable, but unlike 2C-E I never get nauseous.

It is that aspect of 2C-I that I find most appealing. I bump it at shows where I am taping and don't want to have to deal with possibly needing to run puke when I need to run gear.
 
OxyContin Queen said:
You guys, i just wanna say, i have been doign 2c-i and other phenethylamines for over the past 5 years, i've tried all the 2c compounds available, as well as all the different dmt structures.

A phenethylamine that i have ALWAYS had a massive amount of stomache discomfort on was 2c-e, with 2c-e I would always puke, purging and then i would be high, and uncomfortable the rest of the duration of the trip.

2c-i is however incredibly easy to ingest without causing any nausea, if it is in the bulk powder form why not try wrapping it up in a piece of one-ply toilet paper and doing it parachute' style. Or if you want, go out to the health food store, and grab something like some vitamine suppliments in a cap that u can take apart, empty, refill and then ingest.

if you want, i can post a few trip reports from previous 2c-i trips of
mine. If you do 2c-i alot then you will quickly gain a tolerance for it. An example of my tolerance to the substance, well, a regular dose is 14-22 mg for a strong dose. i take 150-250 milligrams on a regular dose.
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My Fiancee, I can verify these doses,on numerous occasions we've taken 1/5-1/4 gram doses of 2ci, granted,its an intense experience, but really when you do that much all you can do is sit back and think that you expected more, i think it has a ceiling effect at around 100mg. This stuff gets most people pretty high on 20mg..I know vendor discussion isn't allowed but we looked it up on the vendor review website and no one has had purity issues with him before
 
Not only that, I've personally (the person saying this has been doing the substance for a timespan lingering over 5 years) noted that I do have permanent HPPD (Hallucinogen Persistent Perception Disorder) which is fact, essentially tracers or random visual distortions throughout my everyday activities.

It happens on occasion, usually 2 to 3 times per week, I can imagine the effects will be permanent. I however, disagree with Ungoliath and think the peak dose effect for this drug limits itself at 60 mgs, after that your body cant absorb it all and it just metabolizes before its absorbed.

Yes, tolerance is an issue. Doses like that are attainable after a week or two of consistent use bi daily. dosing 40 to 100 milligrams.

I'll be honest, we even just used to lick our fingers, dip it into the bag, and then lick it off. We have a saying however; 2c-i tastes like "big foot's dick" and if yas smoke it, it gives u a weird hallucinogenic rush... but its more "sticky" feeling than smoking ketamine.

PS. I think anyone that rectally takes doses .... Why? thats so gross, take your finger out of your ass, clean it off, and start shit the sanitary way. if you have a shit obsession, why not try some Jenkum . like WTF.
 
retired_chemist said:
^^^^ Using 2C-I that much and at the levels you describe strikes me as pretty gross behavior.
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Yeah I found 16-18mg was wonderful while 22mg+ is uncomfortable. So screw 40 to 100 milligram doses.
 
I get extreme nausea on the come up of 2ce. I've tried ginger and chamomile tea. It doesn't work. Can anyone suggest a medication that might help or something else?
 
beezaa said:
the first time i have taken a psychedelic was 2ce, granted i did take it right after eating a sandwich and was very nauseated on the comeup and eventually puked and felt horrible during the trip which caused me to spend the rest of it lying down in my bed. thinking about taking some 2ci in about an hour. and the main thing that could cause the trip to go bad for me is going to be nausea.
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2 options:

1. weed
2. plug

Plugging may be useless if the nausea is caused by the chemical rather than the stomach's tolerance for the chemical.
 
I found it all to be mental, as long as you can think about something other than your stomach, all is well
 
Zofran ELIMINATES nausea

Bottom line: zofran kills all psychedelic related nausea.

Zofran is the reason i became a mescaline addict (well, a quasi-addict). It eliminates nausea caused by serotonergic psychedelics.

It binds as an antagonist to the 5-ht 2c receptors, the ones that the psychedelics bind to that causes nausea. At the same time, it does not disturb the trip or have any mental effects of any kind. It has a very nice safety profile (it's safe as hell), and it's manufactured cheap in countries outside the US.

With it, mescaline went from being - puke all day long, to "puke once" and then it felt about as nauseous as eating some cotton candy (ie: not nauseous).

With some trips, such as dmt or mescaline, i'd recommend eating the zofran after you puke, otherwise it can contribute to unintentional overdoses. One time i took a large over dose of zofran (more than i needed, basically.. there is no overdose level) with 750mg of mescaline in the form of cactus tea and while i didnt feel nauseous at all, my lack of ability to puke meant that i had a much more powerful trip, and the stomach cramps from the juice were terrible. (it does not prevent stomach cramps from foul teas).

Hope this helps someone. Zofran is so powerful and helpful, i feel like it should be in the toolkit of everyone who uses serotonergic psychedelics, as it basically eliminates one of their worst downsides.
 
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i'm more interested in your "quasi-addiction" to mescaline than the remedy for nausea... what exactly do you mean by "quasi-addiction"?
 
feelgoodhit said:
i'm more interested in your "quasi-addiction" to mescaline than the remedy for nausea... what exactly do you mean by "quasi-addiction"?
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i dunno. i obviously never became physically dependent. and i didnt have as strong of cravings as i did for morphine or speed, so i wouldnt call it a full blown addiction. i would call it an addiction where i didnt feel like i had to do it, but i felt like being on mescaline was more fun than being off.

when i first did mescaline, i felt like everything in the world was bright and shiny again, and i basically had the happiest and most euphoric experience of my life. i'm a very sensory and particularly a tactile type of person, and mescaline induced these crazy tactile hallucinations (more so than other psychs for me) that were to put it short, the most delightful and stimulating feeling i've ever encountered. I felt like i was in touch with some secret power of love every time i used, and mescaline use always led to these huge moments of empathy with everyone around me. I enhanced my relationships and felt like i was able to truly love people.

i'd been a big user of amphetamines up until that point (daily for adhd and at times in abuse), and so i also felt at home with mescaline's stimulating buzz.

As stimulants tended to calm me down and make me feel focused, mescaline tended to do the same thing.

Mescaline for me always provided a strong sense of rushing euphoria that was absent from tryptamines (havent tried any other phens or mdma), and i feel this is the reason that i was able to trip on mescaline so often without ever encountering a bad trip.

so i ended up using mescaline 3x per week for about 5 months. i felt like life was better on mescaline than off, and so i called it a quasi psychological addiction.

i never had a bad experience. and no, i dont feel like my mind has been blown up or anything strange like that.

dont you think it's hard not to get addicted to a drug that makes everything in life feel poetic, beautiful, and full of loving empathy???? For most people, i think that the nausea is what stops them from tripping with mescaline more often. That was the case for me, and once i discovered zofran, all bets were off.

eventually i got tired of it. so i guess you could say i wasnt truly addicted :-p.

it's still my favorite chemical substance of all time.
 
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Zofran you say... interesting... and one can just ask for a script?
 
it's possible but unfortunately in the US there's a good chance that it's really expensive. (like $15 per pill or something ridiculous like that).
 
Well, I'm interested. I HATE nausea, and it nearly ruins acid for me, and it's kept me away from mescaline and ayahuasca for a while as well.

Have you compared it to other solutions (ginger supplements or dramamine for example)? I usually drink some ginger tea while I come up, but it doesn't help as much as I'd like, and I haven't heard a lot of other reports about anti-nausea agents. Last year I had chronic nausea which I think was caused by bad drinking water, and any drug that would take it away is something I need in my kit.
 
It's so expensive that insurance might not cover it unless you have cancer. however, i do know of somebody on this board who got it for "nausea of unknown origin". It's *technically* prescribed to lessen the nausea from chemotherapy, but I think it's probably prescribed off label for pretty much any nausea related issue. From what i've heard from doctors, they love prescribing it because they can stick it to the insurance companies, and because its rare that a drug is *so effective*.

Other things ive tried for nausea (ive tried everything)

I've tried ginger, which made me sick and combined in a shitty way with the mescaline. I had psychedelic ginger burps, to say the least, which ended up turning me off all ginger products permanently. I think ginger helped mildly.

I tried all the typical anti nausea pills - meclizine and diphenhydramine, which helped mildly but still didnt do much for the actual psychedelic nausea.

cola nut syrup was also tried, didnt do much of anything.

Pot helped 100%. It supposedly has some action on the same receptors as ondansetron (zofran), in addition to other action. But i didnt really want to smoke 5 bowls an hour (what i needed to eliminate the mescaline nausea) and cloud up my trip. Plus, that much pot is just too much for me.
 
mescaline addict, thats rich. I suppose its possible though on the same level a person can be addicted to anything including a spoon or fork. Most psychedelics have no physically addictive properties though, especially since tolerance increases so fast. Would u use mesc daily or was it like a once a month kinda thing?
 
FrostyMcFailure said:
mescaline addict, thats rich. I suppose its possible though on the same level a person can be addicted to anything including a spoon or fork. Most psychedelics have no physically addictive properties though, especially since tolerance increases so fast. Would u use mesc daily or was it like a once a month kinda thing?
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read my 2nd post in the thread. no i was not physically addicted, and yes i was using several times a week because it was infinitely more fun than being sober. im not saying "oh man i was an addict".
 
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