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The Big & Dandy Methoxphenidine / MXP / 2-MeO-Diphenidine Thread

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There's still time. :) Lower doses (my lower dose was 350mg, mostly of the TA extract which I feel is super important since a plain HCl trip seems incomplete according to numerous people and a bit on my own experience in taking a pure HCl starter dose for the flood dose and a 200mg TA starter dose for the 350mg experience), are appropriate to take without supervision, and it was one of the best trips I've ever had, it started with incredibly realistic and intense open eye visuals and then after a couple of hours I was pulled into semi-waking dreams with my eyes closed, amazing, awesome dreams that were actually better and more cohesive dreams than I had on my flood dose.

The flood dose on the other hand needs to be taken very seriously. I only had constant supervision for the first 12 hours, which in talking with people was deemed to be long enough and that I'd be more or less with it with my eyes open, except I'd want to stay down for a good day and a half longer. Well, I did stay down for the first 2 days, but that third day I got up and was still dreaming while awake, and the world SEEMED to make sense, but in reality, as my friends later told me since I went over to spend the night at their house later, I was mostly talking nonsense and not there. Anything could have happened. What did happen was almost bad enough, I sent weird texts to my parents and a terrible email to my boss because I got in my head that it was several days later than it really was and I was missing work, and the stress of not being able to function my electronics caused me to freak out for about 2 hours, during which all of this happened. Other than the partial awareness and the deeply spiritual and wonderful feeling aspects of it (the whole flood dose - with the TA and HCl combined - felt wonderful, amazing, comfortable), it may as well have been datura because I was really not there enough to function. I may have also talked to my neighbor, not sure, I just remember wanting to talk with him and apparently I told my friend later that I did talk to him, but I also have a memory of him going inside before I could. I've been too scared to ask him if I talked to him. =D He's my age and seems cool, maybe not a drug user, but maybe, and probably cool with him. I did tell him about my opiate addiction prior to this and he was supportive. I want to be friends with him, but if I came up to him babbling about ibogaine and god knows what, he might see me different now.

So yeah, it's a really good story now though, I am about halfway done writing it but as I am feeling pretty much 100% better from opiates now, I am writing it faster than I was, I suspect in a few days it will be done.
Well thanks for the preview this all sounds very intrigueing (as it always does when I read about iboga). I'm really looking forward to the full report. How is memory of the experience anyway? Were you able to sleep while on it? Staying awake for 3 days can get pretty crazy for me.

My biggest problem would be finding someone to watch me for 3 days straight. I really only know one person who's down with such experiments (he just became a doctor actually, so that's appropriate) and who I would also trust (maybe another as well), but I'm not sure if he would and could spare 3 full day. Now I'd still have to score Iboga, which I currently have no clue how to do, neither the plant matter nor the ibogaine hcl.

But really, my biggest issue right now is that I could most definitely not take it with the lithium floating through my body, seizure risk and all that shit. grrrrrr...

Those effects sound sooooo intrigueing. :/

EDIT: Nice hijacking btw ;)
 
Hello chaps i thought that this imght be the best place to post to ask a few questions before i have a dissasociative weekend. Previously i bought a small sample of Methoxphenidine (250mg) and had 2 x 125mg blasts at it. I dont even remember how i too it i think i bombed it in a rizla. At the time i was self medicating as i was planning to go to Peru for some Ayahuasca and had concerns about the SSRI antidepressants i was on. Suffice to say i never made it to Peru but i made my own Ayahuasca in the kitchen and after 18hrs of brewing it i managed to puke it all up as soon as i tasted it. anyhow....

When MXE was legal in the UK i had no idea about harm reduction and must have done about 250mg of that and had the most splendid of times talking to aliens before i jumped out my caravan window naked covered in shit and was chased down the street by 4 cartoon policemen. It really was a life changing experience for me and since then i have become obsessed with Quantum Physics and the like.

Sorry i do ramble.

Now im back on the anti depressants (Mirtazapine). Do you see any problems with me taking some Methoxphedine whilst im on these drugs?

Im thinking of getting 1gm and doing it in 6 lines over a couple of days. I have read the thread but still cant work out the best ROA. I have a Magic Flight Launch Box vapouriser there could that be used at all? Up the nose seems to be a bit nasty but heh i can handle it if its the best. How does one go about sticking drugs up his bum? In a rizla?

Ive also got a load of Etizolam there which i know i will cane later as the weeeknd comes to a close. Should there be any problems there?

The last time my 125mg line almost got me holed. I'd love to get holed again. any recommendations there or is it not really posssible? I felt close to holing last time.

Sorry for all the questions. Ive not discovered harm reduction or anything i just excited about the experience as the girlfriend is away for thw weekend and im gonna go places that she couldnt imagine.

thanks
 
Now im back on the anti depressants (Mirtazapine). Do you see any problems with me taking some Methoxphedine whilst im on these drugs?

Im thinking of getting 1gm and doing it in 6 lines over a couple of days. I have read the thread but still cant work out the best ROA. I have a Magic Flight Launch Box vapouriser there could that be used at all? Up the nose seems to be a bit nasty but heh i can handle it if its the best. How does one go about sticking drugs up his bum? In a rizla?

Ive also got a load of Etizolam there which i know i will cane later as the weeeknd comes to a close. Should there be any problems there?

The last time my 125mg line almost got me holed. I'd love to get holed again. any recommendations there or is it not really posssible? I felt close to holing last time.

Sorry for all the questions. Ive not discovered harm reduction or anything i just excited about the experience as the girlfriend is away for thw weekend and im gonna go places that she couldnt imagine.

thanks
Hope you at least tried to fight those policemen off.

There are no KNOWN interactions. However mirtazapine's pharmacology isn't like that of most antidepressants and I am not very familiar with it either. I'd love to read into it and give you a more educated response, but it's simply too complex for me to feel confident enough to give you any advice. 2-MeO-Diphenidine has been SPECULATED to have some serotonergic/dopaminergic/noradrenergic properties, but this is so highly speculative, that we cannot use that at all. However, you currently have to assume that 2-MeO-Diphenidine makes you go blind, makes your cock and tits rot off and gives your babies Aids, if you catch my drift.

Mirtazapine is NOT known to cause serotonin syndrom, so even if 2-meo-diphenidine was very serotonergic I don't see this happening. then again, I reliably get serotonin syndrome off tramadol+opipramol, the latter of which is not serotonergic.

It's seizure-inducing potential is also know to be very low, eventhough seizures on mirtazapine have occured before. Some dissociatives have been known to induce seizures sometimes (PCP), but this happening is very unlikely on each of the two drugs alone and interactions arent known, since we simply know next to nothing about 2-meo-diphenidine pharmacodynamics.

I personally would not be stopped from taking my dissociatives by being on mirtazapine. In fact I will take said compound with Lithium and Velafaxine in my body sometime in the next two weeks.

Chances are you will be fine, but no one can give you an answer you can rely on.

A classical hole as you can experience on ketamine (or some people on mxe as well) has not been described, but (if its anything like diphenidine which i have taken myself) you can get so much further out with this stuff than with any other dissociative I know of (except for dizocilpine maybe), holing or not holing should not be of any concern. ;)
 
Right, mirtazapine is an antagonist for most receptors like serotonin receptors and antagonists don't really tend to combine dangerously. Although if you stack up antagonist on antagonist (like adding anti-psychotics), I imagine it won't be a pretty sight of someone lying down drooling... Also people should be extra careful with downers among other things, not saying everything is perfectly safe, just not regarding SS and the like.

I've taken mirtazapine for about a year and dissociatives worked alright, which was nice since I couldn't really trip on psychedelics (did not really try even - apart from dissociatives + 5-MeO-DMT which did work).

But I'd still certainly watch out with methoxphenidine like you all should - medicine interaction or no, good point!
 
So I have moved to a place where I cannot get MXE domestically but I can get MXP, which I only heard about and started researching today. I am not looking to go on crazy dissociated trips I am just looking for something that may have similarities to what I experienced from low dose MXE. I.e. anti depressive, in fact extremely happy, very chatty, social, no anxiety and motivated, whilst going about my day as usual. Could MXP be the replacement? Has anybody experimented with lower doses of MXP here? Even higher doses of MXP, did it make it difficult to communicate? Could you pull off walking normal and pulling of to people that your sober? I came to a point that I could even take 100-150mg of MXE and pull off acting sober, although I couldn't speak as I would sober so I would intentionally just speak slowly and not long sentences, like I was tired or in one of those slow speaking moods. On low doses however my speech was improved and I could speak very fast and coherently. Anyway, just want to know how it compares to low dose MXE, any comments would be appreciated thanks
 
I have no experience with mxe so i cant compare it to that but iv done a fair bit of ketamine in the past. Iv only tried mxp at doses from 10mg - 50mg and i found 30mg to be my sweet spot for what i want from it (I have a low disso tolerance). 30mg gives me slight euphoria, stimulation, motivation but it still feels quite manic and nutty. I had a pretty rough experience on 50mg when i smoked some kief which sent me into a panic state where I paced around my house completely confused. I haven't tried it since. Gona wait for more info and experiences to surface before i give it another go. Before that experience i was using it nearly once a week at around 30mg and i was able to get work done around the house and even write up a power point presentation.
 
Be careful, you need to have a good scale to weigh those doses and be careful with redosing. Because it might not be the kind of trippy hallucination you were looking for, it's more out-in-the-world functional craziness than some semi-holing IMO. Overdosing is more risky with 3-MeO-PCP and 3-MeO-PCE (good luck finding that last one).

3-MeO-PCP is for the seasoned dissociatives user, and even several of them have come to tell us that 3-MeO can be a grim animal that can lead to very very fucked up episodes.
 
3 meo is no joke and should be avoided by the casual user and used only by the sane psychonauts out there.
 
I'm getting my first order of mxe soon and as I've never tried it before, are there any side effects that I should be aware of specifically?

I've heard the current batch is a good batch <3
 
2-meo-diphenidine, is it more comparable to pcp or mxe to those that have tried both? Doesn't seem very comparable to ketamine based on what ive read in this thread... comparable to dxm?
 
2-meo-diphenidine, is it more comparable to pcp or mxe to those that have tried both? Doesn't seem very comparable to ketamine based on what ive read in this thread... comparable to dxm?
I've only tried diphenidine, but the dissociative closest to it of the ones I've tried would DEFINITELY be pcp.
 
Stay safe people,

Aus England (UK) wurde eine Warnung bezüglich der neuen psychoaktiven Substannz 2-MeO-diphenidine übermittelt.

Die neue psychoaktive Substanz 2-MeO-diphenidine (1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine) steht im Zusammenhang mit einem im Jänner 2014 ereignetem Todesfall (34-jähriger Mann)!

2-MeO-diphenidine wurde mittels toxikologischen Tests im Blut in der Konzentration vom 24,0 mg / L (analysis by ROAR Forensics, Ltd) nachgewiesen. Weitere Substanzen waren nicht beteiligt.

Confirmed death in England (from the European Early Warning System for NPS)
 
^Link?

If you've never had a close call on a dangerous drug before stock up on methoxphenidine, I guess. Many of the new synthetics seem to have a lot to do with English distributors, one way or the other.
 
I still don't understand the cultural (or other) reasons behind that? It just happens to be the RC center of the world? Rather that to go off-topic I think I'd better make a topic over in EADD...
 
Wow the news is in. This guy apparently took a whopping dose, 24mg/L sounds like a whole lot. I don't know about the kinetics, but considering that it should pretty much be present in all tissue, that it gets metabolized very soon after entering the body and that even 24mg/L would still mean 120mg per 5l of blood, it seems like he took 100s of mg's. This should still be unsettling of course!

Just for comparison's sake, keep in mind that the two substances might be distributed very differentely in the body:

In four cases from living subjects with unknown doses, concentrations of methoxetamine were found from 0.13 to 0.49 µg/g. In three of the cases, the blood samples also contained natural or synthetic cannabinoids.
This ends up as being roughly 0.13 - 0.49 mg/L compared to the 24mg/L in the deadly 2-MeO-Diphenidin overdose... So that's about 100 times more 2-MeO-Diphenidine than MXE flotating through the blood.

We should still be careful of course, but it seems this guy was reckless as fuck, possibly even intentionally overdosed, who knows. It's also possible he had a massive tolerance and his liver failed due to the large doses, IF said substance is even metabolized in the liver that is.

Can anybody with more knowledge on pharmacokinetics and toxicology comment on this?

A warning is still in place of course, but it seems like this guy did NOT take a recreational dose of the substance. Shithead is gonna get this stuff banned, but that was just a matter of time I guess.

Seems like a disaster waiting to happen.

The only report I found on it the person blew through 750mg of it in a night, leaving only 14mg of their sample left over...

That ended up with a 12 hour duration with effects until 18 hours.
Now imagine somebody binging like that who has a massive tolerance which seems to be a very real problem with frequent use of this substance.
 
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Well, I just went through a gram of this stuff from a reputable source. I have a bit of tolerance my usual MXE bumps are in the 80-100mg range and it'll take a few of them to get me anywhere near a hole, 3-meo-pcp 25mgs is about right to be fucked but mostly coherent until a redose. I've pretty much broke DXM for myself, and MXP seems to tap into my insane DXM tolerance.

So I measured out a 110mgs for my first go with MXP, and got the ol' +/-, second go 200mg, little bit wonky but nothing to write home about, 80mg plugged redose might of done something maybe. Waited a week and then ended up doing the rest of it 300mg to start, 200mg two hours later and it was....really nice. Felt like a heavier warmer m-hole with more of those nice feelings of streaching out forever, music was fantastic..but it didn't really develoup into anything. Think for my rusty old nerves I'd of had a proper good time if I took 4-500mgs right off the bat like an even more reckless dumbass.
Don't think I'll be ordering anymore though, better things out there that don't take a half gram to get me where I'm going with a slightly better and better known safty profile.
I can totally see someone needing a gram of this for proper effects, and then taking another gram and then killing themselves.
 
so here i chime in on 100mg oral did quite a lovely wobble, clear, dissociation. bit like MXE minus the headfuck. ability to function remains but you get wrapped into a cotton wool sort of fluffy state. hard to describe.. its sedating and euphoric at the same time. as if you'd be wrapped in a tactical force field. this is where it gets interesting.. tactile sensations seem to be present and need further investigation. i'm a fan of the "floating" sensations on K or MXE, but 100mg MXP lacks that for me aparently.

although i have to add that ROA wise: vaping is a pretty surprising treat. no harsh smoke. goes off foil very easy. doesnt taste shit and is actually pleasant compared to other materials i vaped (even the salt forms..)

my face is tingeling, my eyelids are vibrating, my fingertips are hypersensitive... not so bad of a first impression.
 
Stay safe people,



Confirmed death in England (from the European Early Warning System for NPS)

I sent this over to Sekio the other day and IIRC he reckoned based on a few calculations that the guy potentially consumed > 10g to begin with. 8o Jesus christ that's scary, I wouldnt want to take 300mg of this stuff, even 200mg is overkill imo, as tragic and scary as it is I seriously hope this guy was intentionally overdosing and there aren't people out there who actually think it's okay to consume such an insanely ridiculous amount.

I'm fairly certain that while these seems to be dopaminergic that it also has serotonergic effects like MXE, 3-MeO-PCP, DXM etc, so it's worth being cautious and not overdoing the doses for the same reasons as with those, and with the even steeper dose response curve, considering the difference between threshold, medium and hole effects is very small compared to the difference between 0 and threshold effects, it's worth being extra careful with the dosage with something like this.

120-140mg Methoxphenidine in bed eyes closed is all you need for a lovely floaty time <3
 
I sent this over to Sekio the other day and IIRC he reckoned based on a few calculations that the guy potentially consumed > 10g to begin with. 8o Jesus christ that's scary, I wouldnt want to take 300mg of this stuff, even 200mg is overkill imo, as tragic and scary as it is I seriously hope this guy was intentionally overdosing and there aren't people out there who actually think it's okay to consume such an insanely ridiculous amount.

I'm fairly certain that while these seems to be dopaminergic that it also has serotonergic effects like MXE, 3-MeO-PCP, DXM etc, so it's worth being cautious and not overdoing the doses for the same reasons as with those, and with the even steeper dose response curve, considering the difference between threshold, medium and hole effects is very small compared to the difference between 0 and threshold effects, it's worth being extra careful with the dosage with something like this.

120-140mg Methoxphenidine in bed eyes closed is all you need for a lovely floaty time <3
I wonder how he made those assumptions though. Concentrations in various tissue can vary enormously, depending on the substance. He might have compared this to substances with similar o/w partition coefficients, molecule size etc., but then these parameters don't fully determine how it will be distributed in the organism.

I really appreciate someone with better knowledge of pharmacokinetic is taking a look at this, but I hope no one makes the assumption that using 2-3g or even 1g in a day is okay!! He might have very well only had 1g, eventhough this would be very surprising, it's a possibility, e.g. if he injected the whole amount and died very quickly.

On a sidenote, after having been so enthusiastic about diphenidine, I decided to finally try 155mg 2-MeO-Diphenidine orally 40min ago, without tolerance. Music sounds amazing. Added another 45mg after 50min for a total of 200mg oral.

EDIT: At T+3:00h there's still some lingering dissociation, but i've been full functional. Here comes the bummer though: I remembered having an important appointment 100km away from home right when the stuff hit me, so I ordered a cab and actually managaed to make a clean impression despite slipping in and out of reality. I think I kinda wrecked some of the taxi's equipment pulling stuff when trying to adjust my seat into a comfortable position. Very calm, very easy, very much unlike diphenidine. I liked diphenidine a lot better though. I'm on 75mg velafaxine and 1mmol/L lithium, but noticed no serotonergic side effects. I figure this substance is not very or not at all serotonergic. I'll redose another 240mg now. I did that and later dosed 200mg diphenidine. Nothing to wrtite home about, except for the splitting headache. On 1-10 scale it is a 7. Ouch.

EDIT2: Okay doing the math after yesterday, I guess what I did was reckless as shit. I dosed:
T+0:00 155mg 2-MeO-Diphenidine
T+3:00 245mg 2-MeO-Diphenidine
T+6:00 200mg Diphenidine
WTF was I thinking?!?! I had no tolerance. I actually ordered a taxi at T+1:00 and was relatively okay to communicate and walk I guess. Still nothing I would've anticipated. I even switched off my phone and removed my facebook password from firefox, but apparently all this cannot hold me back from doing stupid shit anymore. Surprisingly I was fine it seems.

EDIT3: This won't be of any direct interest to most people, but today my lithium levels were up to 1.7mmol/L, almost twice what they should be (0.9-1.0). No idea how this would relate to my diphenidine spree of yesterday, but at least I've got a good explanation for my headache.
 
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