BACKGROUND:
Polymorphism. or the existence of a compound in more than one crystalline structure, is a well-known phenomenon in chemistry and in pharmaceutical production. TheWidipedia entry on Poloymorphism (in Materials Science) indicates that it is not unusual for a single compound to have two or three common polymorphic forms. In nature, polymorphism can be readily observed by comparing any two snowflakes. Although all snowflakes are composed of the same root molecule (H20) each snowflake has a crystalline structure that is unique as compared to every other snow-flake; snow flakes produced at a given temperature and pressure may be said to have some characteristics in common (take for example snow flakes produced when the temperature is in the teens or single digits (Farenheit) versus snow-flakes produced when the temperature is just slightly below freezing. Of course, while snowflakes produced under these two conditions will tend to have some characteristics in common (such as size) each snow flake neverthess has a crystalline structure that is unique from ever other snow flake produced under the same condition.
To date, based on 1H (Proton) NMR analysis combined with subjective analyses and evaluation by a body of persons, (removed source) has concluded that there are at least three (3) MXE polymorphs that have been produced since MXE was introduced in late 2011 to early 2012 by the members of the A.I.R.C.R. in the UK. It should be born in mind that, as used in this discussion, 'polymorphism' may refer to
(A) cases in which a molecule is presented in the form of a given crystalline salt (for example, a Hydrocloride (HCl) salt) where different different facilities or laboratories ultimately produce different polymorphs of the same salt and/or where the the same facility/laboratory produces different polymorphs of the same salt at different times; and
(B) cases in which a molecule is presented in the form of an alternative salt (such as a Hydrobromide (HBr) salt) - in which case the same root molecule will take on a unique crystalline structure because different types of salts (HCl, HBr, etc) inevitably have different crystalline structures.
When polymorphism occurs, although the root molecule is present, different polymorphs may vary considerably in terms of potency as a function of time (i.e how quickly effects are realized, the duration of effects, and duration of 'after-effects') and potency as a function of weight (i.e. the degree of effects realized for a given amount). Furthermore different polymorphs may also very in the precise effects they tend to produce - although similarity of effects also tends to be observed when comparing different polymorphs of the same compound. Differences in the potency and effects of various polymorphs may understood as deriving largely from differences in the solubility and bio-availability of different polymorphs. Small changes in solubility and/or bio-availability can produce marked differences in the way in which different polymorphs interact with the miraculous brain and body.
One common example of alternative-salt polymorphism can be found in over-the-counter decongestants. Most decongestants that contain psuedo-ephedrine are presented in the form of a HCl salt. However, some psuedo-ephedrine decongestants are presented in the form of a HBr salt.
A common example of same-salt polymorphism may be found in the difference between certain 'name-brand' compounds (such as Xanax) and their (supposedly) equivalent 'generic' versions (such as generic Alprazolam). Relatively few individuals who have grown accustomed to Xanax will fail to notice when a 'generic' variety of Alrprazolam is substituted for Xanax - even though Xanax is nothing other than Alprazolam. It appears that, in the U.S.A. at least, it is frequently the case that a 'name-brand' represents the 'protomorph' of a given compound (e.g Wellbutrin) while generic versions represent one or polymorphs of the same compound (e.g. Buproprion). This helps explain why many patients who have grown accustomed to a 'name-brand' product do not adapt well to a 'generic' version of the same product.
It seems worth noting that is an amazingly well-kept secret of the pharmaceutical industry that the precise mechanisms governing the phenomenon of polymorphism are not fully understood and that the appearance (and disappearance) of different polymorphic forms may elude the ability of a given laboratory to control and reproduce them. Persons interested in finding out more about polymorphism may find that Bill Bryson's discussion of polymorphism in - A Short History of Nearly Everything - offers an instructive, and accessible to the lay-person, introduction into the bizarre nature of polymorphism.
POLYMORPHISM AND METHOXETAMINE:
Given that Methoxetamine has been produced, presumably in Megagram (1,000 Kilogram units) quantities, by different facilities around the world over the past two years it does not seem surprising that several polymorphs of Methoxetamine would have been achieved by various production facilities during this time. What is somewhat striking is that, as far as can be ascertained, (removed source) is the only entity who has offered MXE for nearly two consecutive years who has made an effort to identify and distinguish different polymorphs of MXE offered in the interests of promoting awareness of, and increasing understanding about, MXE polymorphism and the potential or actual impact of polymorpism with respect to the effects of MXE from different (or even the same) sources. It has become increasingly apparent that different polymorphs of Methoxetamine may produce certain effects so distinctive from one another that a person experienced with one polymorph of MXE may incorrectly conclude that a different polymorph of MXE is not even Methoxetamine but is some other compound (such as 4-Meo-PCP or N-Ethyl-Ketamine) that has been incorrectly or fraudulently traded as Methoxetamine).
Over the course of the past two years, (removed sourc) has offered Methoxetamine as Molecular Sacrament in three different forms:
(A) (removed brand name) {as protomorph of Methoxetamine or 3-MeO-2-Oxo-PCE}. Offered initially in April of 2011 (removed brand name) represents what may be understood as the 'protomorph' (that is, the first polymorphic form) of MXE originally created for the Association of Independent Research Chemical Retailers (AIRCR) who trademarked the name 'Methoxetamine' (a term that has come into such common usage for 3-MeO-2-Oxo-PCE as to render the trademark legally moot) and subsequently ordered its synthesis at the Megagram level by a pharmaceutical laboratory in India (circa late 2010). People have reported over the past two years that (brand name removed) offers the beneficence of pain relief (analgesic), heightened awareness of one's self and surrounds; improved alertness; improved sociability and greater ability to discuss sensitive & emotional issues with loved ones. In general, (brand name removed) has not generally been reported to foster increased drive (motivation) to 'move about' but rather tends to lead to contentment and satisfaction with one's status at the moment (e.g. standing, sitting, lying down). However, People have notreported that (name brand removed) produces a desire to simply be sedentary all or most of the time.
(B) (brand name removed) {as polymorph of Methoxetamine or 3-MeO-2-Oxo-PCE}. 1H (Proton) NMR analyses using D20 as solvent performed on a sample of (brand name removed) in February of this year (2013) confirmed that (brand name removed) is Methoxetamine. Much like the (brand name removed) polymorph of MXE, (brand name removed) shares many of the beneficent features of (brand name removed) (such as pain relief and increased acceptance of self and others) while possessing beneficent features that are distinctive from (brand name removed). Specifically, people have reported that (brand name removed) may be more beneficent than (brand name removed) in situations where physical activity (such as walking, dancing, doing housework) is involved or desired as (brand name removed) seems more apt to foster or support motivation (drive) to 'move about' and be physically productive.
(C) (brand name removed) {as polymorph of Methoxetamine - or 3-MeO-2-Oxo-PCE} emerged in early 2012 as the single most prevalent "polymorph" of Methoxetamine being produced en-mass for most of that year. However, by late 2012 it became increasingly difficult to source (brand name removed) {polymorph of MXE} as producers became increasingly reluctant to ship to the United States. The most distinguishing feature of (brand name removed) was that people almost universally reported that it increased the brightness and brilliance of colors and tended to foster "crisper" or "sharper" visual perception. Similar to (brand name removed) is was frequently reported that (brand name removed) was associated with greater drive (motiviation) to move about and be physically productive as compared to (brand name removed).
REPORTED SIMILARITIES AND DIFFERENCES IN THE BENEFICENCE OF METHOXETAMINE POLYMORPHS:
In terms of the subjective effects of (brand name removed) {protomorph of MXE} & (brand name removed) {poloymorph of MXE}, People consistently report observing/experiencing the following features with respect to the effects of (brand name removed) and (brand name removed) upon oral ingestion:
• (brand name removed) EU synth {at 20-35mg level}:
o (A) provides significant relief from acute and/or chronic pain for several hours without blocking the ability to feel and experience pleasurable sensations and without other troublesome side-effects and the problematic dependency potential of opioids such as oxycodone;
o (B) often fosters a feeling or sense that on is resting or "floating" in time and space - as if on a inner-tube or floating with a life-vest on;
o (C) produce a calm, serene, somewhat "dream-like" state that is paradoxically punctuated by heightened awareness and lucidity;
o (D) tends to lack any marked physical-stimulant action (like that of caffeine) - yet tends to increasing awareness & mental alertness;
o (E) tends to produce a sense of contentedness & satisfaction with where ever one presently is at and/or is presently doing (i.e. improves awareness of and appreciation for the 'now').
o (F) promote emotional openness, empathy, and acceptance of one self and others;
o (G) provide rapid and often long-lasting relief from feelings of depression and/or anxiety by fostering a more peaceful and optimistic outlook that lasts for days or weeks after just a single instance of beneficent use.
• (brand name removed) unknown location synth {at 30-45mg level}:
o (A) provides significant relief from acute and/or chronic pain for several hours without blocking the ability to feel and experience pleasurable sensations and without other troublesome side-effects and the problematic dependency potential of opioids such as oxycodone;
o (B) often fosters a feeling that one is moving ever-so-slightly in a upward motion - perhaps as if rising slowly in a hot-air balloon.
o (C) tends to have an energetic or stimulant action similar to caffeine while being longer-lasting than caffeine and absent of the 'jitters' or 'crash' that may accompany the use of caffeine.
o (D) may improve mental focus and foster the ability to stay "on-task" toward the achievement of a goal.
o (E) may foster increased drive (motivation) to be physical active, productive, and social.
o (F) promote heightened sociability, greater openness, and acceptance of one self and others;
o (G) provide rapid and often long-lasting relief from feelings of depression and/or anxiety by fostering a more peaceful and optimistic outlook that lasts for days or weeks after just a single instance of beneficent use.
• (brand name removed) China synth {at 30-45mg level}:
o (A) provides significant relief from acute and/or chronic pain for several hours without blocking the ability to feel and experience pleasurable sensations and without other troublesome side-effects and the problematic dependency potential of opioids such as oxycodone;
o (B) often fosters a feeling that one is moving slightly forward or "gliding" gently through time & space as if slowly-moving foward on surf-board, toboggan (sled), ice skates, or roller blades;
o (C) often heightens the sensitivity of the visual-sense including a brightening of colors and a perception of improved 'sharpness' 'crispness,' and 'clarity' of vision;
o (D) tends to have an energetic or stimulant action similar to caffeine while being longer-lasting than caffeine and absent of the 'jitters' or 'crash' that may accompany the use of caffeine;
o (E) may foster increased drive (motivation) to be physical active, productive, and social.
o (F) promote heightened sociability, greater openness, and acceptance of one self and others;
o (G) provide rapid and often long-lasting relief from feelings of depression and/or anxiety by fostering a more peaceful and optimistic outlook that lasts for days or weeks after just a single instance of beneficent use.
That polymorphs of the same molecule 3-MeO-2-Oxo-PCE (that is, Methoxetamine) tend to produce different effects may be attributed to the fact that polymorphs often differ in their relative rates of solubility which can impact to their relative degree of 'bio-availability' or the speed and ease with which a given substance may be absorbed and subsequently enter or pass through the various systems and substrates of the human body; the rate at which different polymorphs of the same molecule are metabolized by the liver may also presumably differ. Differences in solubility, absorption, and metabolism may all contribute to the variations in the effects of the polymorphs of Methoxetamine.
Of course, each person should bear in mind that his or her experience with any given polymorph of MXE may differ from what others commonly report; in fact, each and every experience with any given substance, or any substance that effects the neurochemistry of the brain (from caffeine, nicotine, and alcohol to psychotherapeutic medicines), shall ultimately be unique due to the nature of our miraculous brain, Just as no two snowflakes are alike, so also are no two experiences of any kind, alike. Indeed, the very nature of human experience is that each moment can be experienced only once - and our experience of each and every moment is unique and can not be exactly or precisely duplicated.
) I think is full of shit but I wanted to share it with you folks for discussion.
