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The Big & Dandy Methoxetamine Thread: 8th dose, I can't sleep so why not?

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I plugged about 10 mg along with some hydrocodone before I went to work the other day. It felt as if I had taken a stimulant of the amphetamine type. Felt good to talk and speak my mind, had inebriation somewhat similar to what having a few drinks of booze is like. The next night I subbed another 10 mg, fell asleep and had vivid dreams.

A few days before that, I insufflated 40 mg, then 30 minutes later subbed another 20mg and became oddly dissociated. My vision was the first to change after about 40 minutes. Only slight mental psychedelia, and zero visuals besides the fact that my eyes seemed to see a copy of what I had just saw moments before I looked somewhere else.(I'd compare it to DXM, where when you close your eyes and still see the outlines of everything). Music set the mood as to how my mental state felt. Mostly emotional sensations though. 4 hours in, my thinking seemed crystal clear, despite feeling as if I was completely confused physically. I went for a walk and basically sobered up entirely after wondering around by hour 6.

I preferred the IR w/ the hydrocodone experience exponentially more than the 40mg + 20mg experience. It seemed as if I was on 3 different drugs between those 3 experiences. Seemingly very unpredictable substance. I'll still be continuing w/ it's experimentation in order to find a pleasurable middle ground in the days/weeks to come.
 
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missimoo said:
after years of depression and anxiety. which resulted in a breakdown about 5 years ago...followed by a cocaine addiction, I was discharged from the mental health services in the last 2 months having complelty turned my life around (I was complelty agoraphobic, crippled with anxiety and my life was in chaos)..I dealt with my issues and got on with my life. I am for the first time since I was a teenager, a fully functioning member of society with no health problems. MXE has helped my anxiety, removed my depression, PTSD etc from day one. and made me lose interest in all other drug taking including alcohol (I have even given up smoking).... on my early trips on MXE i dealt with issues, I "tripped out" past trauma's during MXE trips including a time i was raped, my parents divorce and various other "complexes" so not only have i a full bill of health from my GP, i also got it from the psychiatrist...to the point that I no longer have to see him. i was open in that i may have unknown health issues related to MXE, but none have shown up, you have really just attacked me.

i dont like your tone. please post with some respect. i clearly made the point that I wasnt BOASTING about my excessive dosing, but that I was amazed that i was WELL AND FIT after such long abuse, and it was abuse. if you have nothing positive to contribute. instead of slamming people. ...I suggest you back off. (FYI.. I didnt say I took a gram a day for a year, a said i used UP TO a gram a day, with breaks. that was a MAXIMUM...if your going to slam someone ...please dont misquote them)
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Good for you. I can see MXE having therapeutic instrospective potential. It all depends on how and why you're using it.

I drank about 150mg MXE as I went through my day including classes. It felt more psychedelic and the effects were elongated and more gradual in nature (because it digests and gets into the bloodstream slower and more gradually). It was really enjoyable and felt different from snorting, which feels more edgy and to me is a quick trippy dopamine rush (also enjoyable) with some tolerance.

As for using it at a rave or social situations, I would say it can enhance whatever type of event you're experiencing. That being said try getting a feel for it and becoming accustomed to the effects with different ROA's before using it.
 
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mexr said:
I drank about 150mg MXE as I went through my day including classes. It felt more psychedelic and the effects were elongated and more gradual in nature (because it digests and gets into the bloodstream slower and more gradually).
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Do you have a big tolerance to MXE? If I drank 150mg MXE before class I would probably end up crumpled up in a ball in the middle of the lecture hall.
 
Has anyone reported a loss of the sense of taste from continued sublingual MXE abuse?

I've been pretty bad since picking up my biggest amount of MXE yet. 4.5 grams and have almost been dosing daily via sublingual administration.

I have noticed that I don't enjoy food or drink or even cigarettes as much anymore and my mouth has felt quite strange over the last few days.
 
Been reading up on ketamine abusers and LUTS, and I'm curious if anyone has experienced any of these symptoms. I've seen anecdotal reports of lower back/kidney pain from MXE abuse, and, not to scare monger or anything, but I suspect that we will start seeing problems in users once we've reached a point in time where abusers of MXE have been at it for an extended period of time. If this is the case, I'm wondering what the rate of bladder toxicity is compared to ketamine.

This journal article in particular had some interesting data on symptoms: http://www.ncbi.nlm.nih.gov/pubmed/18680495

All patients had severe LUTS, with frequency, urgency, dysuria, urge incontinence and occasional painful haematuria.
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Do note that the mean of ketamine abuse in these respondents was 3.5 years and the range was 0.5–10. They also seemed to recover to some degree after halting their ketamine usage.

I don't have journal access to the few toxicological articles of choice on MXE specifically, but I'm not sure there has been any academic insight on specific toxicological effects and mechanism with MXE thus far. So, has anyone experienced any LUTS symptoms?

Also I'm wondering about a common synthesis impurity the DEA isolated in their microgram bulletin:

A significant amount of a by-product (impurity) was
produced during the synthesis of methoxetamine. The FTIR
(Figure 12a) of the synthesis impurity indicated that a carbonyl
was present and its mass spectrum (Figure 12b) indicated a
molecular weight of 247. The impurity was easily isolated
from methoxetamine HCl by its solubility in acetone. The
NMR spectrum (Figures 13 and 14) illustrated that this
compound, like methoxetamine, contained a 1,3-disubstituted
benzene (with a methoxy group at C3), an N-ethyl group, a
ketone, a quaternary carbon, and an n-butyl chain. However,
the proton and carbon chemical shifts and the HMBC
correlations show that the ketone is the bridge between the
benzene ring and a cyclopentyl ring and this cyclopentyl
ring contains the quaternary carbon which is bonded to the
N-ethyl group. The isolated impurity was characterized as
[1-(ethylamino)cyclopentyl](3-methoxyphenyl)methanone
(Figure 15).
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It can be cleaned up with dry acetone, as I would suggest any user to do in the name of harm reduction. But I'm wondering if anyone more knowledgeable would like to speculate on its potential toxicity.
 
^^^It's as if I've lost sensitivity in the inner lining of my bladder. It's become harder to detect when I have to pee.

Occasionally I feel my urinary tract and kidneys burn, and sometimes it burns when I pee. The worst I've gotten was pain radiating to my genitals. Only once, though. I've cut down considerably since, but I have yet to completely keep my greedy hands off it.
 
As for the question of whether or not this stuff is good for a Rave, I very much believe so. On Saturday I insufflatted 45mg. Felt amazing for a good 2, maybe 3 hours. Continued with another 30mg. Again, waited 2 to 3 hours and finished the night off with about 25mg. The whole time I felt amazing. I didn't talk to much of anyone, I was mostly doing Poi all night and I must say this drug got me so into the act of spinning that people were constantly coming up to me giving me compliments.

On a side note, I insufflated one gram within 4 days last week. Afterwards, I noticed slight chest pains and the very occasional nosebleed. The batch I had is the white fluffy batch that has been going around, so I believe it is of purity and was not harsh at all on my nose or body. I'm wondering if this chest pain in my lungs could be caused by the chemical getting in there? It was very subtle, slightly hard to breath when I expanded my lungs all the way. Nothing to really worry about, but I 'm curious as I love snorting this drug. I'm not very interested in other means of administration.
 
No doubt I was extremely high, but not the point where it was obvious to other people. Like I said drinking it is a lot smoother and gradual, and I didn't dose all at once this was over ~4 hours. I do have some tolerance, I used around 3.5g over the last 2 weeks, I'm looking to cut back my usage considerably and take more breaks.
 
Chris Timothy said:
^^^It's as if I've lost sensitivity in the inner lining of my bladder. It's become harder to detect when I have to pee.

Occasionally I feel my urinary tract and kidneys burn, and sometimes it burns when I pee. The worst I've gotten was pain radiating to my genitals. Only once, though. I've cut down considerably since, but I have yet to completely keep my greedy hands off it.
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According to the article on ketamine abusers, all of them scored both high on the PUF scoresheet, and all of them showed signs of bladder inflammation, with severe cases having small bleeding wounds indicative of classical interstitial cystitis. "For the most part, people with interstitial cystitis will either have lots of pain and very little frequency or they'll have lots of frequency and very little pain." A few high-dose ketamine abusers showed presence of papillary necrosis as well. The physiological mechanisms that cause these conditions is unknown, but if you're interested you can read the authors' speculations here.

Whatever the cause is, we're seeing very similar symptoms in MXE users. I just wonder if the frequency required by MXE to produce symptoms is less than ketamine, or if the availability (and abuse potential) of the drug is the reason we're seeing a good number of people report these symptoms.
 
Since there are 10% of toxins left in metabolized Aspartam; is it considered "safe" to take MXE some time after also ingesting Aspartam (trough Nutrition)?
 
has anyone had migraine FROM HELL when mixed with MDMA? i took MDMA about 4hrs after a low dose of MXE. I havnt taken MDMA in years. I had THE WORST MIGRAINE i have EVER had on the MDMA, no one else had one, and i was the only person who had taken MDMA. ...strangely.. on the comedown i took MXE out of desperation (to be dissociated from the agony)..and the combo was AMAZING. the pain went.

i also was VERY SICK. but i remember i always used to be sick on MDMA years ago. however i was sick repeatedly throughout the night (followed by the migraine)...no one else had either the pain or vomiting and as said, no one else took MXE with the MDMA which was pure crystal (as far as i can tell, it was just one large crystal)
 
yes. all kinds of horrible things when MDMA and MXE are used close together. they're a very bad mix
 
I am really wondering why so few people seem to take it orally. Is there something fundamentally wrong with it?! For me it has always been the best ROA. Even directly after a meal, the onset is pretty quick. Why bother with the taste (and loss of taste apparently) if you are going to swallow it anyway. Or is it that some of you guys just like snorting stuff? plz enlighten me... thx
 
omsian said:
I am really wondering why so few people seem to take it orally. Is there something fundamentally wrong with it?! For me it has always been the best ROA. Even directly after a meal, the onset is pretty quick. Why bother with the taste (and loss of taste apparently) if you are going to swallow it anyway. Or is it that some of you guys just like snorting stuff? plz enlighten me... thx
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I personally just like snorting things. I guess it's the whole ritual of putting a bump on my hand, and snorting it up my nose.
 
^ same here. love snorting things, especially when drunk. think thats why ive ended up in such a pickle, snorting MXE whilst drunk is very ill advised... lol
 
Chris Timothy said:
^^^It's as if I've lost sensitivity in the inner lining of my bladder. It's become harder to detect when I have to pee.

Occasionally I feel my urinary tract and kidneys burn, and sometimes it burns when I pee. The worst I've gotten was pain radiating to my genitals. Only once, though. I've cut down considerably since, but I have yet to completely keep my greedy hands off it.
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I'm wondering if symptoms like these can be reduced with a different ROA and perhaps keeping up on plenty of water intake during your usage. Can anybody share their opinion on this?
 
water intake is extremely important, key to the afterglow and a good trip i find. feel like shit if i get dehydrated on mxe. used to get kidney aches and mild burning from too much alcohol in the past, plus MXE use didnt help and made it worse, but ever since upping my water intake ive been fine. 4/5 litres a day, give or take. might be a bit much for some people though, depends. deffinetely helps the kidneys etc though
 
ColtDan said:
water intake is extremely important, key to the afterglow and a good trip i find. feel like shit if i get dehydrated on mxe. used to get kidney aches and mild burning from too much alcohol in the past, plus MXE use didnt help and made it worse, but ever since upping my water intake ive been fine. 4/5 litres a day, give or take. might be a bit much for some people though, depends. deffinetely helps the kidneys etc though
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I always bring water around, especially with drugs like this. I just like to stay hydrated, but the downside is that having to take a piss every now and then on 50+ milligrams of MXE can be a little bothersome. Last night at a friends house I used the bathroom that's literally right next to the room and when I came back I felt like I was entering a new universe. If you were wondering... I'm not sure how much MXE I took, but the extra 50 MG that night really blasted me off.
 
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