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The Big & Dandy Methoxetamine / MXE Thread - Part 16 - Sweet 16 mind-control machine

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Doldrugs there is a lot of infererior batches going around, a shame really. The good stuff is like night and day in comparison. I'm on day 5 of my on cycle, feelsgoodman. Nice to have good stuff right now, which can be dosed daily without repercussions for up to a week at a time. Just stay hydrated and take plenty of supplements and good food.
 
Since I had the day off I decided to eat 120mgs in place of sniffing my usual 100mgs(in the name of science!). I took my dose right before going to the mall so mrsROXI could pick up some crafts for her dance studio. It did indeed have a more "magical, rolling" vibe to it. Sniffing my usual 100mgs has a more wonky dissociative feel to it. I thought I caught myself harmlessly flirting with female cashiers(complementing them on their finger tattoos and striking up unnecessary conversation, ect) but m'lady was standing right next to me smiling so it must not have been too bad. I was also showing public displays of affection which I never do. My conclusion is that (for me) oral dosing requires slightly more material but results in a warmer MDMA-esque experience while insufflation is more dissociating.
 
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Oh ROXIanne! said:
Since I had the day off I decided to eat 120mgs in place of sniffing my usual 100mgs(in the name of science!). I took my dose right before going to the mall so mrsROXI could pick up some crafts for her dance studio. It did indeed have a more "magical rolling" vibe to it. Sniffing my usual 100mgs has a more wonky dissociative feel to it.
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That makes me more interested in trying oral dosing again; however, the wonky disso effect is what I love about mxe.
 
I'm soo happy to be able to use actual cannabis again with my mxe instead of synth-noids. It feels much more safe.

In other news, Tianeptine and mxe seem to go together quite well. I have been avoiding the combination for a month or two on nights I had to use tianeptine in order to stave off kratom w/d but one night I accidently used mxe after using 200mgs of Tianep and found a great synergy. So much so that I am considering finding way to add 150mgs of tianeptine to my first plugged dose of mxe.

Last update: At some point last week I decided to mix all three of my equally top-notch polymorphs into the same container and mixed them up the best I could.sorry mods if this counts as "batch discussion" feel free to delete Doing this has really affected characteristics of my beloved m-hole universes.
 
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Note that I was previously avoiding that combo due to unknown interactions. I'm not sayng it is definitely safe to use tianeptine with mxe, just that I had a good experience. I tend to be cautious of mixing anything with mxe since so little is known about it.
 
I'm on the last bit of my stash today, will try to stretch it out by drinking lots of white grapefruit juice with it (it really works to potentiate it!)
 
So is MXE metabolized by the P450 CYP3A4 enzyme then? That's news to me. I know GFJ works for opiates and some other things so it definitely could.
 
foolsgold said:
So grapefruit really works ? Might have to get some to go with my 5 g I've got coming soon
Right was wondering will this mix well with escaline ?
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It mixes wonderfully with escaline. Just watch the dose of escaline as the higher doses feel somewhat dangerous. I've tried 50 mgs once and 80mgs twice spread out over a couple months. 50mgs made for a good trip with notable G.I. distress(just like mescaline). Both 80mgs trips were overall enjoyable but the bodyload was quite harsh and it felt pretty hard on the heart. Again, I'm refering to escaline here and not mxe(sorry for the derail)
 
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Xorkoth said:
So is MXE metabolized by the P450 CYP3A4 enzyme then?
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Yes apparently
http://www.ncbi.nlm.nih.gov/pubmed/22023129

Chemical inhibition was strongest with inhibitors of CYP2A6 and CYP2C19 in canine and equine microsomes and with the CYP3A4 inhibitor in human microsomes.
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Yet 4 other enzymes may also be involved.

As oral MXE use doesn't seem as wasteful and dirtying as seems to be the case with K.... the point of enzyme inhibition for MXE use seems to be mainly potentiation I would guess. But for K it seems a lot more interesting if you can go for a trip without norketamine; .. who knows - even if you were to eat the K! Then again, I would still be prepared for loss via first-pass metabolism.

I don't see any downsides using GFJ when the drug to be potentiated is not potentially (no pun intended) dangerous, do you?
 
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FlawedByeDesign said:
It mixes wonderfully with escaline. Just watch the dose of escaline as the higher doses feel somewhat dangerous. I've tried 50 mgs once and 80mgs twice spread out over a couple months. 50mgs made for a good trip with notable G.I. distress(just like mescaline). Both 80mg trip were overall enjoyable but the bodyload was quite harsh and it felt pretty hard on the heart. Again, I'm refer to escaline here and not mxw(sorry for the derail)
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Thank you for the reply I found proscaline mixed really well with mxe at Christmas and hoping for this to do the same :-)
 
Late last year I got a 5 gram batch of white mxe with a crystalline consistency. I really abused it over a 3 week period. Doses of up to 200 mg in a night via sublingual or insufflation. Not many side effects other than some chest pain at times, loss of taste, and manic behavior. 2cb and nitrous were great with it, Nitrous especially - though I've read that combination may not be particularly safe. Never once got to a hole. I guess I really did abuse dxm, it is the one substance I ever had a real problem with abusing. Those of you with high tolerance to NMDA antagonists , how high do you dose to hole? It is something I would like to experience.
 
what do you mean 'hole'?

I took, 35mg MXE, then 2 tokes of strong cannabis, then I was closing my eyes and saw 3D interior spaces.
 
my first two experiences, sublingual and nasal, respectively, with 30mg were quite strong. I, have used MXE maybe 5 or 6 times in total, spread in 10 months approximately, so tolerance shouldnt have been stabilished. However, my last try with 30mg oral was quite weak! I felt next to nothing, so I am trying to figure what happened.
I thought maybe it degraded, but A quick research in BL tells me its pretty stable. I also dont think tolerance was significative (although I took 60mg of MXM one week before that).
I remember the only time that I took it nasally was quite nice! I was a more social setting and I really didnt notice a big difference, but I recognize I dont have enough experience to conclude that...
BTW, the product i had was off-white, sandy, slightly bitter/salty.
 
ive really found that more often then not I do not enjoy or am scared of having intense mxe trips....the absolute only way i can enjoy a high dose is when i decide that i'm going to close my eyes and listen to music througout the peak, which you may not even need because youll be hallucinating your own music, and go into a hole/enjoying CEVS and tactile hallucinations feels like stuff pushing on me being wrapped in heavy blankets or being upside down or having the sensation of really moving through lots of space. dosing high with doing any other activity in mind (staying in reality instead of going into the hole basically) usually ends with a a just weird or bad sketchy vibe to the trip. however low doses with threshold effects doing anything from a night on the town to working are fantastical!
 
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