I understand I'm quoting an old post, but as nobody pointed it out it still feels helpful to clarify that a lot, if not most experience reports in PiHKAL/TiHKAL for the compounds are not by Ann & Alexander Shulgin, but instead the research group surrounding him or even taken from reports sent in to him by letter.
that was a long time ago, a year when I used deca only which causes low dopamine and increased prolactin. Andrew huberman did a podcast to think about the negative, ive always visualized positive outcomes, and thought bout the absoluete worst as a human, killing myself. I did it based on misinformation and extremely disfunctional brain chemistry .
I have only done this a couple times, so my sample size isn't great. Dosage-response curves are subject to random outlier experiences. That said, it seemed like rectal and oral dosing had similar potency, unlike the 2C-x series (which is significantly more potent rectally.)
It might work. People report being able to redose peyote throughout long sessions, so it's possible that the tolerance window might not slam shut a few hours in. But it might.
I had a somewhat similar experience to this on NYE. I took 55mg of MAL Fumarate in 2 doses spaced about 45 minutes apart from each other. I did not notice anything during the first hour and begun to notice some very slight changes to my vision but nothing I could exactly quantify by around hour 2ish. I had eaten a chicken sandwich about an hour and a bit before I took my MAL and I also had about 0.5mg of flualprazolam alongside the MAL. I had 2 tabs of acid at hour 3 and no MDMA since none of my dealers had any, and I would say the acid completely took over the rest of the night. I will attempt another trip with MAL later this week once my tolerance is reset without eating beforehand and without any other drugs that could alter the experience. A bit disappointed but still very ty eager to experience an actual trip from MAL.