The Big & Dandy Medication/Supplement Interaction Thread

[Solipsis]

Well it's often accepted that psychedelia is a manifestation of the mind, which has more to do with your mind than with ways to achieve psychedelia. Psychedelics facilitate this effect relatively easily but there are more ways to do it like meditation.
Hallucinations are misleading to equate with psychedelia, they have more to do with delerium and more severe forms of realization where you believe something is happening that is not like talking to people that are not there. The definition you read above here says that psychedelics can do this, but its certainly not standard. Hallucinations can happen from things like severe lack of sleep.
While they may appear the same at first because you can experience extraordinary things with both psychedelia and hallucinations, the former is actually a phenomenon arising from disclosed meaning and aspects of your consciousness (as they often have their roots in your normally latent unconscious) while hallucinations are about distortion, noise and unhealthy functioning of the brain.

Sure deleriants have some overlap with psychedelics but IMO the differences are far more important than the similarities!

 

[lolwhatzdrugs]

Well it's often accepted that psychedelia is a manifestation of the mind, which has more to do with your mind than with ways to achieve psychedelia. Psychedelics facilitate this effect relatively easily but there are more ways to do it like meditation.
Hallucinations are misleading to equate with psychedelia, they have more to do with delerium and more severe forms of realization where you believe something is happening that is not like talking to people that are not there. The definition you read above here says that psychedelics can do this, but its certainly not standard. Hallucinations can happen from things like severe lack of sleep.
While they may appear the same at first because you can experience extraordinary things with both psychedelia and hallucinations, the former is actually a phenomenon arising from disclosed meaning and aspects of your consciousness (as they often have their roots in your normally latent unconscious) while hallucinations are about distortion, noise and unhealthy functioning of the brain.

Sure deleriants have some overlap with psychedelics but IMO the differences are far more important than the similarities!

Very interesting point indeed. I've always thought of psychedelia as looking through a full beer glass at what's going on. Everything's distorted, but everything is indeed there.

Whereas hallucinating is far more intense, and hard to tell that what's happening isn't real.

The differences are definitely important! Taking a drug that makes you 'delirious' does not sound like my idea of a good time, but to each his own.

 

[solistus]

I would say psychedelics don't _typically_ cause hallucinations to be on the safe side. If the distinction between OEV and hallucination is distortion of an image that's actually there versus creation of an image that's not really there at all, wouldn't, for instance, a breakthrough DMT experience be hallucinogenic in nature? Or any out-of-body visual experience, for that matter? I'm sure most people here have had trips where the basic nature of sight and vision seemed altered, becoming much more intertwined with whatever headspace you are in at the time rather than simply showing you what is nearby. I've had many peak experiences where I 'saw' things that were representations of some abstract concept or train of thought rather than distortions of an object I was conscious of observing.

I certainly agree that psychedelics should not be called 'hallucinogenic drugs' and that taking potent psychedelics 'for the sole purpose of hallucinating' is not a very good idea. I just think drawing any hard and fast lines defining what psychedelics do and do not do in terms of subjective experience is somewhat of a fool's errand given the unpredictability and variety of possible effects these compounds can have.

 

[Delsyd]

Merged with the Medication Interaction thread

my question is,what sort of trip did you have if you were on anti psycotics or anti depressents,and tried to do a psychedelic drug? .

And you answered your own question with:

myself i diddnt hullucinate to my full potential,at least the drugs that i had done before i went on meds .

 

[lolwhatzdrugs]

I would say psychedelics don't _typically_ cause hallucinations to be on the safe side. If the distinction between OEV and hallucination is distortion of an image that's actually there versus creation of an image that's not really there at all, wouldn't, for instance, a breakthrough DMT experience be hallucinogenic in nature? Or any out-of-body visual experience, for that matter? I'm sure most people here have had trips where the basic nature of sight and vision seemed altered, becoming much more intertwined with whatever headspace you are in at the time rather than simply showing you what is nearby. I've had many peak experiences where I 'saw' things that were representations of some abstract concept or train of thought rather than distortions of an object I was conscious of observing.

I certainly agree that psychedelics should not be called 'hallucinogenic drugs' and that taking potent psychedelics 'for the sole purpose of hallucinating' is not a very good idea. I just think drawing any hard and fast lines defining what psychedelics do and do not do in terms of subjective experience is somewhat of a fool's errand given the unpredictability and variety of possible effects these compounds can have.

Very well put. I concur wholeheartedly.

There are some crazy people who portray cannabis as a hallucinogen and some people who barely agree that it produces any psychedelic effect past being a mild intoxicant.

 

[Mercury (Hg)]

Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines, 2-ct-2, DPT, DMT etc, Salvia) Hallucinogens and venlafaxine can be relatively safely combined, without any significant impact on the effects of the hallucinogen being used.
Do NOT take venlafaxine with a MAOI of any sort! This is a VERY DANGEROUS combination that can lead to serotonin syndrome and death!

This is partially inaccurate. I say partially because one can increase the dosage of the hallucinogen to achieve standard effects. It's misleading at best.

Can anyone help me concerning the effects of combining 2c's with Venlafaxine (SNRI)?
So far, the only possibly dangerous combinations I've seen could be from the 2c-t-x variety, as they act as MAOI's.

What about the other 2c's?

 

[Mercury (Hg)]

This is partially inaccurate. I say partially because one can increase the dosage of the hallucinogen to achieve standard effects. It's misleading at best.

Can anyone help me concerning the effects of combining 2c's with Venlafaxine (SNRI)?
So far, the only possibly dangerous combinations I've seen could be from the 2c-t-x variety, as they act as MAOI's.

What about the other 2c's?

BUMP! Information nowz. I demand it, please!

 

[RPsipine]

Psilocybin/Psilocin and Clozapine

*Apologies for quotes - didn't notice the dates and had to put it back together again after scattering posts hither and yon. Doh!*

I've researched about taking shrooms while in treatment with clozapine (150mg a day for 7 months) and I haven't found any experience or anything.
What I've found is that Psilocin is an 5-HT1A and 5-HT2A/2C agonist, while clozapine is a 5-HT2A receptor antagonists (Am I right?).
Does this mean that a trip in psilocybe cubensis will be altered while in clozapine? Does anyone has any information on this?
Any help or additional information will be appreciated.

PD: I'm having clozapine for depression treatment, not for schizophrenia

This might do better in PD, but I'll shift it over to BDD for now.

HOMELESS -> BDD

Moved to PD per OP's request.

BDD -> PD

Welcome to PD, as well as to Bluelight, RPsipine. Unfortunately, I dont know much about shrooms. You might want to wait for someone more knowledgeable to verify this before you consider taking anything.

Love

From what i have read in the past anti-psychotic drugs block the effects of psychedelics.

Also if you are prescribed a drug like Clozapine, which is an anti-psychotic usually prescribed to schizophrenics and the like, perhaps its best that you not trip right now.

Ive been on various anti-psychotics for many years including a short stint with Clozapine. I can tell you that most if not all anti-psychotics will pretty much eliminate any and all effects you might get from typical psychedelics. In fact you can take heroic doses of LSD and shrooms while on Clozapine and you will barely feel a thing

Cloazpine appears to have more affinty for 5HT1a then 5HT2a....but yeah, its likely the effects of tripping will be negated to a large extent.

I finally ate about 4 - 4,5 grs of psilocybe cubensis and no effects at all (just feel a little sedated)
Thanks for the info anyway

UPDATE:
I stopped taking clozapine about 3 months ago. The last weekend I ate 3,5 grs of psilocybe cubensis and finally tripped, but the effects only last for about 3 hours, while my friends, who ate the same amount, tripped for about 5-6 hours. I think that the clozapine effects are somehow still present.
I'll try it again in the future

 

[Pegasus]

Buprenorphine and RC's

Buprenorphine has a really long half-life and thus will still be kicking around in my system quite a bit on some days that I would like to dose RC's (namely 2c-c, 2c-e, 2c-t-2) in the evenings of these days. So... anything I need to consider on these occasions?

I remember one time I took some cubensis mushrooms not long after a methadone dose (don't know for sure if I was on MMT at the time), and it just made the experience a really sedated, unable to move my head from my hands-type mess. I'm hoping to avoid this...

 

[Roger&Me]

I don't think there's much to worry about-- even with the alkylthio 2c's (2c-t-x), as buprenorphine is used clinically with MAOIs under certain circumstances, and as long as dosages are kept reasonable it is safe.

That being said, I would still exercise caution. We have very limited data on the pharmacology of these compounds, so we can't really accurately advise you on the possibility of dangerous interactions. IMO though, if you keep dosages reasonable its unlikely you will encounter problems.

 

[Mr Blonde]

Hello, fellow BL'ers!

I was just forcefully medicated with 2mg of risperidone orally. I was planning on taking LSD either tomorrow night or the night after.

I am planning on inducing vomiting immediately, or as soon as possible, but should I not be able to how negatively will this one off dose affect my trip?

I would hate to have to re-schedule.

 

[anonymous_mouse]

I read through this thread and from what I can tell, abilify decreases the effects of mushrooms - but I take it every morning and have tripped just as hard as anyone else. Then again, I usually have taken mushrooms towards the afternoon or night, so it's not exactly at the same time as the abilify.

I also take lamictal, but I really can't stop that as I would have to taper up when I started again. So far I haven't noticed any interaction between abilify, lamictal, and psychedelics, but I would really like to have a strong trip on mushrooms so... should I stop the abilify for a couple days?

 

[greenmeanies]

mouse: only your doctor can answer that.

again i ask, why were you put on abilify in the first place? how did you feel before you started taking it? how do you feel now?

blonde: who the hell would do that to you?

 

[Mr Blonde]

mouse: only your doctor can answer that.

again i ask, why were you put on abilify in the first place? how did you feel before you started taking it? how do you feel now?

blonde: who the hell would do that to you?

Stopping an anti-psychotic suddenly could lead to an episode, depending on what he was put on it for.

As for me, my family forced me to take it they watched me take it too. I think I vomited it up though, I didn't feel sedated much last night and don't feel sedated today.

 

[Delsyd]

you should still trip fine if it was a 1 off dose a couple days before a trip.

 

[noswot]

zoloft & lsd

So, I was just prescribed Zoloft yesterday. 25mg for the first week, 50mg the second week. During the second week, I'll be dropping 4 hits of acid. Will the zoloft severely dampen my trip if I take 4 hits? I was going to take 3 but I'm upping it to compensate for the possible dampening. Does anyone have experience with this?

 

[droogz]

Does any one here know if lamotogrine can interact with any psys ? espicaly mescalin ?

 

[Middleway]

I need some info on agomelatine. I have got a box here waiting for me to start taking them. I need to know if there is any interaction between agomelatine and lsd or maoi's

 

[Secret Agent Chick]

I would like to find out about interaction between Lexapro (SSRI) and certain RCs?

How would a dosage of Lexapro (10mg per day) affect it if you were to take either Methylone OR 4-mec? And what about risks?

 

[Survived Abortion]

As far as I know, there are no contraindications between SSRIs and empathogen stimulants like methylone. Although I've never used methylone, I have taken MDMA whilst taking SNRIs, many times. 4-MEC I'm not sure about, but again, given it's pharmacology I don't see a problem. The potential problem would arise if you were to combine either an MAOI with the SSRI, or an SSRI with the SSRI, of which neither of the aforementioned drugs are a class.

Having said that, you may experienced a diminished effect from the methylone; most, if not all serotonin releasing drugs are reduced in their efficacy by the concominant administration of SSRIs. Whilst you will feel the effects of stimulant drugs, they may too be slightly diminished in potency by the action of the SSRI.