The Big & Dandy Medication/Supplement Interaction Thread

[ford442]

same goes for MDMA - also it is a bad idea to mix X and anti-psychotics health-wise..

 

[mitchb]

I'm rolling pretty hard on Marinol at suggested dosages. Less than prescribed dosagees but I am tripping none the less. That would disclude the fact I cannot be tripping from a psychadelic. I would not risk the side effects because of the risperdol but there must be a chemical or natural source which would take me farther than canabis without being negatively affected by the risperdone. Risperdone is not like chlorpromazine which directly antagonises the receptors involved. I am in the belief there may be a psychadelic which may work for me. Perhaps a dissociative. I LOVE NITROUS. I used to look forward to my dental cleanings for the nitrous alone. One dentist had a rig which took me as high as any very pleasant acid trip. I tripped home all the way from the dentist's office on many pleasant memmories. I have had a lot of fun on nitrous but have no idea how I would go about getting a tank. It would be too much if I had a tank but a few balloons woukld be fun. A small tank would be worth the excercise and if I thought hard about it I might be able to get a tank but I imagine I would need a licence in order tyo fill the tank.

 

[helium-4]

Asking for sources or hook up is not allowed.


On topic, I would give ketamine a try.

 

[Delsyd]

yep K seems like a good candidate for a psychedelic exeperience

 

[newbie007]

I don't know where you guys got your information but Resperidone mainly acts as a dopamine antagonist which is why it is used as an antipsychotic. It works on serotonin to a lesser extent. Since you are still getting stoned means that even your dopamine receptors arn't completely blocked. Chances are that if you took LSD, you would still trip. A lot depends upon the dosage level of resperidone. If you are still concerned, you could always just skip a dose when you take the acid. Another suggestion is to switch medications. If you have bipolar or something there is always lithium.

 

[Delsyd]

Riperedone is a dopamine antagonist, but it also retains action at 5HT receptors.

And personal experience has shown me that riperedone will stop a trip dead in its tracks.

 

[Delsyd]

Merged with medication interaction thread.

 

[Shambles]

Learning this about Salvia, how do opiates affect the effects of salvia?

Salvia had zero effect on me other than a mild fuzzy feeling and a slight headache when I was using opiates (heroin) daily. That was smoking a gram of good quality 20X in an hour too so I wouldn't hold out too much hope. Maybe others had more luck but I've heard/seen many opiate users report little or no effect from Salvia. As mentioned above, ketamine may be a more worthwhile option.

 

[chaoticc]

Tripping on dxm with Celexa in the system?

So my friend here wants to trip tomorrow with me. It's really sad though, he's on celexa now though, and we're always having spiritual trips

So he's been taking it for about a week and a half. It's an ssri, so I know the most that would happen is he wouldn't trip as hard, right? Any dangers here, or will it be alright?

Btw, last week he had taken celexa for the past 2 days and we tripped hardcore, he was just fine. But its been a week since then so I don't know.. just throwing that out there.. any opinions?

 

[Solipsis]

Not tripping as hard as normal in combination with SSRI's goes for serotonergic agonist psychedelics, which DXM is not.
What did you take last week when you 'tripped hardcore', do you mean on LSD or DXM or something else entirely?

DXM with SSRI's can be dangerous so be sure that there is like 1, much better yet 2 weeks at the very least between stopping medication and using DXM. But: never quit medication like that for any other reason than that you are actually done with it!
The combination can cause serotonin syndrome so stay away from it.

Merging this with the medication interactions mega-thread.

 

[any major dude]

DXM isn't a serotonergic psychedelic. Its an NMDA agonist, more akin to ketamine & PCP. Hence the SSRI's wouldn't lessen the effects like they would for a serotonergic. However, most SSRI's inhibit, at least somewhat, the enzyme CYP2D6. This enzyme is very important in the metabolism of DXM, hence SSRI's & DXM are contraindicated. Probably best not to use the two simultaneously, however if you're planning on doing it anyway, you should definitely start with a very low dose & gradually work up from there. In all honesty I wouldn't even recommend that though.

 

[Solipsis]

Yes they rely on the same metabolic function ^ but the end result can be serotonin syndrom if you don't watch out.
I would say that it is foolish to try out drugs or combinations that lead up to toxic overflow of neurotransmitters. Just like MDMA with a MAOI is stupid to try for potentiation. In any case it's not worth the risk.

 

[TestingPurposes]

Tianeptine (Stablon, Coaxil, Tatinol) Interaction with LSD / Psilocybin:

Lately I've been taking Tianeptine for Anxiety with Coexisting depression. It has worked out surprisingly well, which is unfortunate...Because it's not covered under insurance within the United States. Regardless, I'm intrigued by its unique SSRE effects in conjunction with psychedelics such as LSD or Psilocybin. Granted, I'm no expert on the neuro-chemical systems, only about enough to get myself in trouble. But it's my understanding that Tianeptine has relatively little effect on the SERT or 5HT-1/2 receptors with a higher affinity for the other guys, 5-HT4/7/etc.

Does this imply that it shouldn't actively alter the uptake of LSD/Psilocybin into the synaptic cleft? How do you think it would subjectively alter the experience?

(To be honest, I have already combined it with both LSD and Psilo, (1/2 blotter and 1.6 grams respectively) though I'm not sure what effects it had. I was in a great mood both times with relatively little intrusive thinking, had energy, a clear head, and minimal anxiety. The experience was not excessively strong or long at these doses, but it did seem a bit heightened. This may have been a placebo effect due to my expectations.)

Thanks for any feedback.

 

[pharmakos]

not only do most ssri's and dxm both get broken down by the same enzymes, but dxm is also itself an ssri, so there is a possibility of serotonin syndrome developing with the combination.

 

[*drug my (b)rain*]

taking antipsycotics as medication,and taking a drug to hullucinate?

I dont really venture into the world of psychedelics,iv done pretty much every one of them that iv ever came into contact with... but what im wondering,is for a few months every few years for the last 5 years,iv been on various medications,and more often than not,i would take a hullucinogenic drug for the sole purpose of hullucinating,i dont konw if this made me better off or farther worse in the long run,thats not my question,and its completly irrelevent to this thread,my question is,what sort of trip did you have if you were on anti psycotics or anti depressents,and tried to do a psychedelic drug,myself i diddnt hullucinate to my full potential,at least the drugs that i had done before i went on meds , and if possible what sorts of side effects would you have if you were taking ssri's,snri's,benzodiazapines,sleeping pills,antipsycotics,the reason im asking this is therest things about my disorders that i dont konw,and could do again without the proper information,thanks bluelight,il check this in like 2 weeks and mabey il see some info worth more than gold.

 

[lolwhatzdrugs]

This doesn't seem like too advanced of a question but, anyway...

Many hallucinogens work by binding to the 5-HT2A receptor in the brain. Since many anti-psychotics are potent antagonists of this receptor; they may block hallucinogenic effects of psychedelics.


It goes without saying, if you're being treated for any sort of psychosis or the like with anti-psychotics, and they're helping you, you need to continue your treatment, and stay away from psychedelics.

 

[nuke]

--> pd

 

[Help?!?!]

Psychedelics do not cause hallucinations. They will cause O.E.V's or open eye visuals but they will not cause you to see things that are not there(what a hallucination is). If you take psychedelics while on anti-psychotics it will do nothing. If you take psychedelics on anti-depressants the effects will be diminished. If you take psychedelics because you want to "hallucinate" you will get slapped in the face with a horrifying experience eventually.

 

[PhillyPsychonaut]

I used to take Geodon (ziprasidone) for bipolar disorder and mood swings, and I never had trouble tripping. I only did shrooms, acid and 2c-e while on the drug, but I did not have any reduced effects. The only negative feeling that I had was on 2c-e, but I was on 42 mgs and 20 mgs at different times. It might have been the high dose that gave me a very uncomfortable trip, but I felt like I was going crazy both times I took the 2c-e. I was also on Wellbutrin too at the time, but I'm not sure if that had anything to do with the negative side-effects.

 

[lolwhatzdrugs]

Psychedelics do not cause hallucinations. They will cause O.E.V's or open eye visuals but they will not cause you to see things that are not there(what a hallucination is).

ORLY?

psy⋅che⋅del⋅ic
  /ˌsaɪkɪˈdɛlɪk/ Show Spelled Pronunciation [sahy-ki-del-ik]–adjective

1. of or noting a mental state characterized by a profound sense of intensified sensory perception, sometimes accompanied by severe perceptual distortion and hallucinations and by extreme feelings of either euphoria or despair.

2. of, pertaining to, or noting any of various drugs producing this state, as LSD, mescaline, or psilocybin.

3. resembling, characteristic of, or reproducing images, sounds, or the like, experienced while in such a state: psychedelic painting.
–noun

If you think that psychedelics are incapable of causing hallucinations, you have never tripped moderately hard on an anticholinergic.

(Although typical anticholinergics are classified as "deliriant," people still use them recreationally to achieve a sorta psychedelic experience.)