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The Big & Dandy Medication/Supplement Interaction Thread

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SPC123 said:
Ok, well ultimately maybe a mod will want to move this where it belongs. I asked a simple question and I guess now I am answering that question myself.

I have no experience with LSD, other than once when I had taken so much valium that it didn't count. So these observations are as honest as I can be.

I am on Effexor 150mg. This is my second week at 150, titrating from 37.5, by 37.5 each week. This will be week 6.

I dropped 1 hit of what was called "pretty strong" LSD 4 hours ago. A second hit 90 minutes ago. I have drank 4-5 beers in this same time frame.

Right now, acid doesn't seem all that different to me than a good alcohol buzz. I feel happy and energetic. I have to concentrate to type this. Visually things are... "wavy" I guess would be the best way to describe it. I am not seeing things that aren't there, but there is definately visual distortion. Other than this, notta.

Bottom line: I would say effexor stops an acid trip at least to the point where it's not worth tripping. I seriously feel like I ought to pop some oxy to get the night really rocking. If it wasn't for the "wavy" way things look, I wouldn't even know I was on acid.

As for shambles predictions of doom (I know bro, you're just giving your own experience, no disrespect intended) I really feel too good to mind. You could tell me I was dying of cancer right now and I wouldn't care. I guess that's an effect of the acid as well, but someone with more experience using LSD might be able to help me understand how euphoric this drug should be.
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Haha glad things turned out ok :) You generally wont see things that aren't there on acid, except for patterns on shit.
 
Yeah dude, that's kinda how it is. There is this one picture over the toilet of a jellyfish, and I can just stare at it and it does all kinds of crazy stuff. lol.

IDK, I still can't decide is acid on effexor is worth it, but the trip so far hasn't been bad.
 
Well, I think I am in a position to say that if you are on effexor (or probably any SNRI for that matter) LSD isn't really worth it. I wouldn't say I got nothing from the trip, but for my first trip ever it was less than stellar. I would much rather have done 20mg valium w/ 40mg oxy. THAT combo fucks you up WAY more than two hits of acid + a dozen beers while you're on effexor.
 
one time i took a good dose of liquid while on my Zyprexa - it did VERY close to nothing.. i think any effect i thought i felt was due to the fact i was mentally and physically prepared to trip - like i sat in my bedroom in the dark for a little while and felt really peaceful, but again, i spent all day thinking about it building up in my mind that something good was about to happen.. quite a surprise since i knew the acid was good.. at least now i know there is no bad reaction between the two.. (not that i am going to trip much if at all with my condition)
 
Yeah, there is definately no bad reaction for me. I'd be feeling it by now I'd think. Clearly if I want to trip on acid I need to come off of the effexor first. Perhaps I will try it cold turkey. See if all this SSRI withdrawal crap people talk about is as bad as it sounds. HAH.

But seriously, it's over 6 hours since I did my first hit and notta. If you are on an SNRI and considering acid, save your money. Opiates on the other hand.....
 
nearjat said:
Lol, wow! That's exactly what I'd wanna read while waiting for acid to kick on on an SNRI ;)
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Heh. Not too tactful reading it back. Was more a case that anybody who happened to get unlucky with that combo would be a bit taken aback that anybody would risk it rather than wait 24 hours. it's always a risk whether you've had problems with combing them or similar drugs before or not - I had done many times for years with no hint of a problem other than having a milder trip as happened here. Just happens sometimes and you don't get any warning no matter whether it's your first time or you've done it a thousand times before with no trouble.

Like all those kinda things, unless it happens to you it's just one of those things that only ever happens to other people so isn't a real risk at all. It's not like it's far worse than anything you can begin to imagine if it's nice and only plays gentle with you, might kill off an organ or two, possibly do the vegetable thing or be one of those pesky lil potentially fatal interactions is it? Only kills a few people so doesn't count really so why bother waiting a whole day to turn a small risk to a complete lack of risk?

Wasn't good timing or well put but I was somewhere midway between disbelief that it wasn't worth 24 hours to cut the risk to zero and genuine fear for what could happen. But I know I'd have probably done the same if I were him - it really is always somebody else. Right up until that one time it isn't.

That aside, I'm kinda glad you had a disappointing trip cos there worse possibilities. Wait till you're off the meds and I'm sure Lucy will treat you right. Glad you're okay and sorry if that was a bit freaky to read <3
 
If I were tripping it might have been freaky. heh.

I am calling my doc tomorrow and getting off the meds. They do more harm than good.
 
LSD and Abilify interaction

In the past month... I've probably taken 3 doses of abilify at 15 mg. Those doses were exactly last week today.

Now I came across some acid today... and picked up two hits. I don't come across acid much so I bought them.

My question is though, will LSD and Abilify have any interaction, even if I haven't taken my abilify for a week now, and only 3 doses in the last month? The half life on Abilify is pretty long, 70+ hours I believe... It's also a weird antipsychotic, partial agonist of 5ht1 and antagonist of 5ht2.


Any insight would be great. Thanks.
 
Delsyd said:
i would wait 5-7 days to make sure all the Abilify is out of your system.

Taking Abilify with LSD will cancel the trip.
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Thanks. It's been 7 now so maybe I'll just drop it. I was more concerned about adverse reactions like a seizure perhaps? I don't know, I read nothing will happen, then I read never mix the two. Just a bit confused.
 
Abilify + PDs (2C-I) ? experience anyone?

Hi boys and girls!

my gf and I are planning to trip with some 2c-i for the first time. regarding the spiritual state/condition of relationship we're in right now it seems pretty appropriate if not necessary...
nevermind.
the problem is she's taking abilify (aripiprazol) against depression et al.; 2.5mg/day(that's very, very low...)

well, regarding the fact that it's a 5-HT2A antagonist I would assume dulling effects on any psychedelic. on the other hand the dose is extremely low and I've heard that abilify unfolds neuroleptic effects only on higher doses...

obviously, I absolutely do not want her to have a terrifying body high without any mental effects (like MDMA and SNRI produced for me :! )....


does anyone have any experience with that "combo"?


and to eliminate any possible interaction: how long before the experience should she stop taking the abilify?

-

I trust in BLs competence and remain thankful for any advise!
<3
 
Risperdone and LSD

I am wondering if the effects of years of risperdone use would affect the LSD experience. Would the experience be nullified by this atypical antipsychotic or would there be an experience at all other than sympathetic stimulation?
I have used Risperdal for years for a condition which is at bay but would this drug inhibit the effects of LSD? I smoke canabis and occasionally get visuals so I am not dead but I wonder if I could roll again on acid. Some of the pot I smoke can be similar to a 1/4 hit of acid if my head is in the right place.
 
Do not take risperidone and LSD. Risperidone is an antagonist at the 5-ht2a which is where LSD gets it hallucinatory action, so you won't be able to feel the LSD.

Salvia is an agonist at the kappa-opioid receptors and doesn't affect the 5-ht2a receptors, so reisperidone shouldn't have any effect it.
 
I am not wanting to do acid and then do a Risperdal. I'm on Risperdal once at bedtime. What would be suitable to trip on? If I can't do acid then what? I am capable of getting trippy on canabis but what might be safe or at least worth trying that would not bounce off the risperdone? I am terrified of going directly to hell on Salvia so I won't do it. I used to like acid and shrooms. I was never into the more designer drugs of nowadays. I'm on dexedrine as well so I have the feeling extacy would be a waste because of both my amphetamine tolerance as well as my steady blood level of risperdone. I think the reason the dexedrine has not completely killed me is because of the fact I was on risperdol the entire time which has never allowed me the full effects of amphetamine. This is a good thing however as I can still think. So what might be a suitable chemical safe to do in my situation. Lets assume I'm not psychotic and am not afraid to be tripping.I miss it. When I smoke I get trippy but as with acid my system developes tolerance to the trippy effects of canabis but this tolerance will disapear as quickly as it may appear and I sometimes smoke with no tolerance and get really high. This is fun if done right. I find the trick is to know your tolerance levels and smoke accordingly.What might be a suitable psychadlic in my situatioon knowing what you do from this post. Assume I am not taking risperdone for psychosis but for other reasons.
 
Cloudy said:
Do not take risperidone and LSD. Risperidone is an antagonist at the 5-ht2a which is where LSD gets it hallucinatory action, so you won't be able to feel the LSD.

Salvia is an agonist at the kappa-opioid receptors and doesn't affect the 5-ht2a receptors, so reisperidone shouldn't have any effect it.
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Learning this about Salvia, how do opiates affect the effects of salvia? I am on Hydromorph Contin 36 mg 4 times per day. I understanmd this is a relatively high dose so it might effect the kappa-opioid receptors but I do not know how Hydromorph affects the action of the kappa receptors. I do know I'm a little terrified to try Salvia which in there lies my answer. I should not think of doing it if I'm going into it scared. I better leave salvia alone but it would be nice to find a suitable psychadelic.
 
All of the classic psychedelics, LSD, mushrooms, DMT, and mescaline are agonists at the 5-ht2a receptors, so risperidone will block the effect of those as well.
 
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