• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe | Cheshire_Kat

The Big & Dandy Medication/Supplement Interaction Thread

Status
Not open for further replies.
I kinda feel like merging the thread so soon kind hurt the responses that I would get. I feel like it should have stayed its own topic for a while so when people look through the threads they will see what is being asked. With this people just skip over it.
 
LSD + Effexor XR?

Every time I've done LSD (which has probably been 4 or so times) I've been on an SSRI. Specifically Zoloft (sertraline) and Lexapro (escitalopram). It worked just fine and loved the experience every time.

My psych has now switched me to 75mg Effexor XR (extended-release venlafaxine, an SNRI, not SSRI).

To my limited knowledge of pharmacology, the interaction of an SNRI+LSD won't be very much different than SSRI+LSD. Am I correct in saying this?
 
lariyn said:
well all together i think 2ci is pretty weak. i dont plan on doing it anymore, and my hppd like stuff is already getting somewhat better. stay away from 2ci.....
Click to expand...
No, I'll enjoy it as the kick ass psychedelic it is, but you, yes should definately stay away from 2ci....if that is of course you even knew what you got.
 
Last edited:
Warfarin-

I can find no specific information, regrettably. I would say that MDMA or anything amphetamine-like is certainly out, too many potential interactions (although nothing is proven), that cannabis is probably safe, and that LSD is probably safe. Sorry I can't provide you with further information.
 
How have u guys noticed the following supplements/smart drugs to affect psychedelics?

I'm the type of person who regularly uses a number of health supplements, vitamins, amino acids, smart drugs, adaptogenic and immuno boosting herbs to better my mental and physical health and I'm also the sort who likes to partake in psychedelics with some frequency. One area that I've not found much information about is what possible interactions psychedelics can have with these natural and synthetic health drugs.

I'm going to list a number of supplements, nootropics (aka smart drugs) and herbs and ask you bluelighters whether you've had experiences using them while tripping. If so, what dosage of the health drug were you using, what psychedelic did you combine it with (and at what dosage), and was the interaction positive or negative (or perhaps you didn't notice an interaction) in your opinion?

The health drugs I'm most wondering about are: Piracetam (or other Racetams), Hydergine, DMAE (or Centrophenoxine), DL-Phenylalanine (or L-Tyrosine), SAM-e, Sulbutiamine, Modafinil (aka Provigil), Vinpocetine, Lecithin, Rhodiola, Phenibut, L-Theanine, Taurine, Niacinamide, Vitamin C, Vitamin B12, CoQ10 (or Idebenone), Calamus (aka Sweet Flag), Ginseng, Eleuthero (aka Siberian Ginseng), Maca, Catuaba, Chocamine, Cocoa, Yerba Mate, Bacopa, Ashwagandha, Coca, Kava, Sceletium (aka Kanna), Blue Lilly, Kratom, Selegiline (aka Deprenyl), Bupropion (aka Wellbutrin), Moclobemide, Tranylcypromine, Amineptine, Tianeptine, Neurontin, Melatonin, 5-HTP.

If there's any health drugs I left off the list that you've combined with psychedelics and had noteworthy experiences feel free to comment on those as well.

Of the above list I've used the following at various times with psychedelics: Piracetam, Hydergine, DMAE, DL-Phenylalanine, SAM-e, Lecithin, Rhodiola, Taurine, Niacinamide, Vitamin C, Vitamin B12, CoQ10, Catuaba, Selegiline, Buproprion, Melatonin, 5-HTP. The majority of times I used any of these health drugs with a psychedelic the interaction seemed either positive or so subtle that it wasn't noticeable. I'm yet to have a time that I've combined a health drug and psychedelic that seemed particularly negative.

One last thing- I'm not trying to recommend you guys go out and combine any of these health drugs with psychedelics as exploring such uncharted territory can obviously be very risky and a double edged sword if one doesn't know what they're doing. My approach when combining health drugs and psychedelics has been to try to be extremely cautious and scientific and listen carefully to how my mind and body are reacting. I've a feeling adaptogens and smart drugs for the most part have the most potential for positive interaction with certain psychedelics if used properly.

My most recent experiment combining health drugs and psychedelics was Friday night when I combined 21 Hawaiian Baby Woodrose seeds (ground finely and mixed into a jar of cold water, peppermint extract, peppermint tea, everclear and lemon juice), some Piracetam, Rhodiola (3% Rosavin powder), Vitamin C, DXM (in the form of one bottle of Zicam Max Cough Mist which is what around 390 mg?) and beer ( 5 or so Miller Lites). The DXM and beer I didn't take until I was coming down from the HBW (abbreviation for Hawaiian Baby Woodrose). The trip was very clear, euphoric and enjoyable for the most part with no harsh comedown at all and an oh so wonderful after glow Saturday morning.

I very much appreciate if any of you can give me feedback on your past health drug/psychedelic combinations :)

Oh, and for the record the psychedelics I've used with health drugs in the past are: HBW, MG (Morning Glory), blotter, MDxx, DXM, and 2CE. I'd love to in the future explore Mescaline containing cacti, Amanita muscaria, Salvia divinorum, DMT and Ayahuasca combined with health drugs.

I've found the right health drugs can really help to cut down on the potential side effects and dangers of certain psychedelics. For example, HBW can sometimes cause a pretty unpleasant feeling of vasoconstriction (unpleasantly tight, twitchy muscles being a common symptom) and I find eating vasodilating supplements like L-Arginine, CoQ10 and Taurine can really help cut down on this.
 
Ayahuasca combined with health drugs
Click to expand...

I wouldn't combine a MAOi with this stuff. But anyway, do you take all of this stuff daily? May I ask why?

Personally, I just eat healthy, though I do take B vitamins, fish oil, magnesium, milk thistle, passionflower, green tea daily for health benefits.
 
The Wizard said:
My most recent experiment combining health drugs and psychedelics was Friday night when I combined 21 Hawaiian Baby Woodrose seeds (ground finely and mixed into a jar of cold water, peppermint extract, peppermint tea, everclear and lemon juice), some Piracetam, Rhodiola (3% Rosavin powder), Vitamin C, DXM (in the form of one bottle of Zicam Max Cough Mist which is what around 390 mg?) and beer ( 5 or so Miller Lites). The DXM and beer I didn't take until I was coming down from the HBW (abbreviation for Hawaiian Baby Woodrose). The trip was very clear, euphoric and enjoyable for the most part with no harsh comedown at all and an oh so wonderful after glow Saturday morning.
Click to expand...

To be reliable this sort of thing needs to be done blind tho. For instance if I'd given you a drink made with a completely different set of ingredients like evening primrose oil, cod liver oil, vitamin A, goat urine, etc would you have been able to tell any difference?
 
^nice list
don't forget the Horny Goat Weed:)

my first few DMT experiences included my nightly cup of kava
the kava helped out immensely in letting me feel like i could lay down in my bed and let the tokes take over,
since then i haven't smoked any without a cup of kava at night, kava is perfect for situations like this
 
Last edited:
I never take DMT without a soupcon of Horny Goat Weed to balance things out ;)
 
^ahah, oh yes.. now that's what i call a transcendental experience

horny goat weed + sex with elves.. quite a combo


edit: oh yea back on topic though, i just started using Rhodiola root powder as few-times-weekly supplement
and was also wondering of psychedelic interactions..
as i haven't indulged in an experience since getting this root powder in
 
Last edited:
I've combined Rhodiola with MDxx's, blotter, HBW and MG before all with good results. It seemed to especially synergize with MDxx's, giving very clean, euphoric, positive rolls that lacked bad comedowns. When I use Rhodiola with HBW it really helps cut down on how sleepy and sluggish the Woodrose makes me feel, causing a more alert trip. When I combine Rhodiola with psychedelics it's usually 2-3 grams of Rhodiola in the form of 3% Rosavin powder. Make sure whenever you use Rhodiola to have an empty stomach as it absorbs best this way. Oh, and Rhodiola works best if you've been taking it consistently every day, as it will build up in your system. Rhodiola also is lovely combined with Kratom.
 
piracetam will blow your mind with acid, itll wire your brain for hyperspeed and acid will turn it on
 
Piracetam also synergizes great with MDxx's or 2CE. Whenever I combine Piracetam with a psychedelic the trip seems so clearheaded, not cloudy and confusing.

I hear Hydergine can potentiate psychedelics real well too.

I used to use SAM-e daily (usually 800 mg) and there were a couple times that I rolled while on it and had really intensely euphoric rolls. SAM-e increases Serotonin so maybe that's why it potentiated my rolls or maybe it was just a coincidence or placebo. *Shrugs*
 
fastandbulbous said:
My experience of 5HTP & 2C-I was enough to make me decide I'll not try nootropics with psychedelics again...
Click to expand...

5htp aint no nootropic. i took 5htp with 2cb and had a horrible time.
 
......I hear Hydergine can potentiate psychedelics real well too.
Click to expand...
thisusername said:
5htp aint no nootropic. i took 5htp with 2cb and had a horrible time.
Click to expand...
Can you guys elaborate on these? I'm especially interested inb the Hydergine/acid combo.
 
Status
Not open for further replies.
Top