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The Big & Dandy Medication/Supplement Interaction Thread

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^Well, you know what I'm gonna say. Don't risk it. Really don't, this time.
* The regularity with which your taking acid will be giving you a degree of tolerance BTW...
 
I took the acid on Monday, and plan on taking it on Saturday. I thought acid tolerance went away within 48-72 hours?

Also, I read that tryptamines are metabolized by MAO-A, not MAO-B, and it would only be dangerous or stupid to combine with Phenethylamines (which some people have done and lived through, but others have had extremely bad trips on, to the point where they had to be restrained from jumping through plate glass windows on low doses, and even though others have had decent trips mxiing them, it's not something I wanna fuck with). But I'd like more input, because ER bills are expensive, not to mention the risk of death.

l-deprenyl doesn't begin inhibiting MAO-A until you hit 25mg, and I'm only taking 5mg. (well, I took 10mg today, but that's still below the threshold).

I just need something to make the acid stronger, because at $7.50 or so per hit, I can't afford to take that much. Aniracetam at 800mg 3 hours before along with 800mg more at the time of dosing 2 hits didn't really give me any more effects than 20mg or so of 2ct-2, other than extra body energy and some shivers/shakes (which could be because I'm still withdrawing from Effexor, it's only been 7 days since I quit 225mg/day).

I just wish I lived in the days of the 60s, when LSD was legal, and blotters contained 200-500ug instead of 50-125ug.

For my next trip I'm planning on dosing 3200mg piracetam on Friday to preload, and then 800-1000mg of piracetam the day of the trip (since more people have had success with this than aniracetam). Still unsure if I should add 5mg deprenyl to the mix. I always have Invega on hand if the trip gets too heavy (similar to Risperdal, should kill the trip instantly within 30 min.), and some xanax bars.

I know you think I'm stupid for fucking with acid when I'm schizo, but to be completely honest, instead of hearing more voices or going delusional, the acid actually STOPPED the voices and delusions. Although I DO NOT recommend any schizo take acid, because when I was first diagnosed and in a psych ward, I met a guy who ate a sheet of blotter acid and now sees or talks to (I forget which) God and Satan, and if you read the erowid vault, it's basically a known fact that LSD can bring out latent schizophrenia.

And I can always lay under a warm comforter and chill out. I'm one of the lucky ones who can sleep on LSD, got a nice restful sleep at 9-10 hrs. after dosing.
 
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LSD + Buproprion/Wellbutrin

Now I know that in theory this combo should be OK, well, at least not harmful physiologically in the sense of causing something like serotonin syndrome, and also that buproprion does not block LSD. As some of you know I recently began taking Wellbutrin @ 300mg daily. I am pretty seasoned with LSD and can handle myself well on it, and obviously, if I were to undertake this combo, would "start low and go slow" in the interests of harm reduction. Before anyone jumps on me I have thought this through quite well, I'm experienced and spiritually grounded, and I know the psychological concerns, tripping w/issues of depression, etc. and really am as comfortable as I think I reasonably could be. In fact LSD is very therapeutic for me and has snapped me out of depression in the past as well as helped me stop drinking (definitely clinically alcohol for at least a few years, problem drinker for many more). Possibly significant, possibly not, I note with some interest that the buproprion gives me very vivid and sometimes quite unpleasant dreams. So down to brass tacks, I am planning on taking LSD again in the not-too-distant future, I have not done so since I have started Wellbutrin, and I would probably prefer not to discontinue the Wellbutrin as that would most likely result in a depressive "crash." I am wondering if anyone has any personal or otherwise anecdotal experience with this combination?
 
Not to bump my own thread, but WOW, the dreams that I am having lately ... Wellbutrin and Ambien really make for quite the dreamtime. I would almost say psychedelic-like experiences in my sleep. Many of which are disturbing. And also marijuana is incredibly potentiated, to the point that I am just not smoking weed these days. For the first 2 weeks I was on Wellbutrin I was stoned just about every waking minute. Then I took a little break, now even average weed in a small amount hits me harder than ever before ... again not always pleasant ... often paranoid. This gives me a little bit of pause on trying LSD whilst on buproprion, but I think I am going to go ahead and do it. I've looked a little bit around on the Internet and most reports are neutral to positive.
 
I started myself on bupropion about a month ago. Years ago I made a self-diagnosis of SAD, although it's never been clinically significant (doesn't qualify based on DSM-IV standards). I'd never use an SSRI - the serotonergic axis is too tightly intertwined with emotion, which I believe is much too complex and too near the core of one's identity to warrant pharmacological perturbation. Since bupropion is approved for SAD and it's not considered to have abuse potential, obtaining a prescription was easy. I've found it gives me a slight mood lift and noticeable nootropic effects.

I've had an increase in dream recall as well ... some good, some bad. Come to think of it, I think last night was disturbing, but I can’t remember why.

I have yet to try any psychedelics, but a break awaits …

Let me know how it goes for you. I’ll do the same. ;)
 
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To clarify, at LOWER doses (5-10mg), l-deprenyl does not have any negative side effects combined with LSD.

It does, however, have negative side effects combined with too much PEA (I had a full stomach and got impatient and kept redosing the PEA). An LSD trip is not fun when your whole left side is in pins and needles from the night before.
 
Hope you have a great time before, during and after you nail the problem that's been bothering you.


:)
 
I dont think what you guys are talking about is potentiation. Which means to make 250ug as potent as 350ug with out the MAOi. Rather it is a synergy of the two psychotropic substances altering the nature of the trip
 
What MAOI have you guys used to boost a Tryptamine? As far as I know the best options are: Syrian rue, Peganum harmala, Harmaline (or is it Harmine?), and Moclobemide. People used to say Passion Flower could be used but I researched it and it contains extremely little Harmaline and actually has a sedative in it called Maltol. And pure Harmaline looks expensive.

'd really to make some Syrian rue resin as I could smoke this during the Tryptamine trip to further potentiate it. Anyone made Rue resin before?

I've used MAOI's before with L, Woodrose and Psilo on different occasions. I always take the MAOI an hour or 2 before. I got my most profound huasca trip from combining 4 or 5 grams of Rue with 12 Madagascar HBW seeds.

I wouldn't be suprised at all if Deprenyl can boost Tryptamines. In this case though I'd think you'd need to be on Deprenyl for days first so it could build up in your system. And I don't think Deprenyl would necessarily be harmful with Tryptamines just because it can be with Phenethylamines.

Some of the folks who warn on hear about combining Deprenyl with other drugs or even warn of taking it by itself I wonder if they've even tried it or are just repeating stuff they heard. I've found Deprenyl to even at high doses have very mild CNS side effects. It's one of the cleanest Dopaminergic legal stimulants around IMO...

One area that's really interesting is combing nootropics and supplements with psychedelics. I've tried Piracetam, DMAE, DL-Phenylalanine, Deprenyl, Niacinamide, Taurine, Magnesium citrate and Lecithin on different occasions with psychedelics and have always gotten favorable results.
 
Wow, *someone* certainly was fairly full of herself in her early days! Or, at the very least, totally lacking in any sense of "how-to-reply-without-sounding-like-pedantic-snotbag." Lol, I'm sure I still haven't gotten it quite right, but the tone of this board has changed a bit as well- between the utter backlash against SWIM and the enormous leap in tolerance for new topics with relatively excavable answers- or perhaps that's just my perception, too?

At any rate, I will definitely concede the potential dangers- both physical and psychological- of mixing psychedelics with psychiatric medications. I can only report my experiences. Having multiple experiences with LSD and Flouxetine in the very early 90s, I didn't hesitate to take it when offered in 1999-2000 merely because I happened to be on sertraline. There were many years of SSRI-free acid-eating in between, and the most intense experiences were certainly during those years. Then again, the most experiences occured within that time, involving surely the largest doses.

I will also affirm that taking LSD brought *me* no harm at all. In fact, it afforded me introduction to some of the most wonderful, diverse communities I've yet to encounter. Within these communities, through the people I met, I found my faith in myself and others, and-at long last- a sense of spirituality.

I still feel that LSD may be unique this way, or at least definitively "less harmful" than the RCs. There was no evidence of any damage from my extensive, repeated use of LSD. For the record, my last use of LSD was, in fact, in 2000. Any "trips" since that time have been on other chemicals, and much less frequent. It might be wise to rethink which chemicals- if any- you choose to indict for an individual's personality issues.

At any rate. . .
5-meo-amt's effects (or whatever it was, that's what it was labelled as, at any rate) certainly did seem to be pretty drawn out, IIRC. That's the presence of irrefutable cognitive distortion, rather than the typical next day "acid hangover" that I recall from years ago. But I don't recall much in the way of "after-effects" from this chem- a relatively common experience it appears, for me, in recent years. I guess I can finally attribute it to bupropion ( drawing out certain effects, entirely killing others.) So, clearly, what blowmonkey said regarding this being a neurochemical issue must have come into play.

nada rylnym- I do apologize. As I mentioned at the head of this post, the tone of this board/ (I hope) my own internet voice have changed. At the time of this thread, I thought I was observing every conceivable protocol, having researched the heck out of the chem in question, attempting to post any relevant info on a little researched chemical along with the details of my question. So while I went overboard in replying to your non-response, surely you get how hurtful it might be to receive such a reply to a conscientiously-crafted query? As for this :
your math sucks
Click to expand...
There should *never* be any doubt!
 
Bupropion does not have the same discontinuation syndrome associated with other modern anti-depressants. Just as you probably noticed that you didn't have to wait a month for it to kick in, there's no protracted tapering schedule involved in getting off. So if your concern is a paxil-like w/d nightmare, you shouldn't worry about temporary discontinuation. Going off of bupropion basically returns you to baseline withi 5-9 days. Until that time, you may experience continued effects as the drug works it's way out of your system, or you may experience a temporary excess of symptoms it was controlling (sleepiness, hunger).

I'm not trying to encourage you to haphazardly go off your medications, just spreading that word. In general Wellbutrin appears to be the easiest and safest to start up/ discontinue.

Which is something anyone should consider doing before taking an additional seizure-threshold-lowering drug. I would be exceptionally cautious in consideration of the effects your are already reporting with bupropion alone. 300mg isn't the *highest* approved dose, but that doesn't mean it's not too much for you. I would actually seriously reccomend disclosing the effects you mentioned to your doctor and being open to a reduction in dosage.

Understand, I'm not taking issue with the psychological effects of LSD. What concerns me is your reaction to Wellbutrin!
 
toe said:
Wow, *someone* certainly was fairly full of herself in her early days! Or, at the very least, totally lacking in any sense of "how-to-reply-without-sounding-like-pedantic-snotbag." Lol, I'm sure I still haven't gotten it quite right, but the tone of this board has changed a bit as well- between the utter backlash against SWIM and the enormous leap in tolerance for new topics with relatively excavable answers- or perhaps that's just my perception, too?
Click to expand...

Thanks, we've worked hard to improve the attitude and meanness and reverse the elitism here and it means a lot to me to hear you say this. Thanks! :)

Are you the OP registered under a different name?
 
LSD and Cymbalta

I went to the doctor today and I was prescribed Cymbalta for my depression. I love to eat lsd as much as I can and I was wondering if I might have any problems taking the two together.
 
well apparently its a serotonin/norepinephrine reuptake inhibitor, so it'll probably be like taking it while on ssri's, which i think reduces the effects. search for lsd and ssri and you should find lots of info.
 
SSNRI's as cymbalta is are different to SSRI's. I don't think theres known interactions, but the NRI and DRI could increase the stimulating qualitites of a trip.
 
Also, it could cause the trip to be much weaker, requiring a higher dose. Everyone seems to be affected differently in that regard (with SSRIs anyway).

In any case, they WILL interact, but it's hard to say exactly how. It should not be dangerous in any case.
 
^I am steadily on the side of not-using-antidepressants. I am really quite frighened as to how I am going to feel over the next year when I come off them. Anyway, just a irreleant thought.
 
Success. I wound up dosing quite heavily and noticed no untoward reactions nor any change in the character of the experience. I feel wonderful in this post-trip glow :D
 
^^Glad to hear it!

I ended up stopping the bupropion a few days into my break for no particular reason so I don't have any combinations to report. I tried 3.2 mg DOM with my family and fiance on Christmas Eve though. Having a morning coffee with my dad while feeling the first effects was certainly a novel experience. And an afternoon round of par-three golf went much more smoothly than anticipated. All in all a wonderful day.

=D
 
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