I've used psychedelics like LSD with racetams like piracetam or aniracetam (which is much more effective for me), and I just used my usual dose like 750 mg. Aniracetam is more potent but I still always took a similar dose so I guess it's no wonder it is more effective.
Honestly I don't remember what kind of dose of LSD I took but 200 ug was not abnormal for me at the time.
Normally when one combines drugs it is not smart to take your usual dose of each, but to go lower. However I never considered nootropics as drugs and I did not expect a lowered dose to work out. I guess in my case it worked out because combining usual doses of each was fine, but I will not claim that this is recommended for everyone and it's entirely possible for someone to have a very extreme reaction. If you read Xorkoths report on piracetam with 2C-E you will probably understand what I mean:
http://www.erowid.org/experiences/exp.php?ID=48983
The only thing in general that I can say about the combo is that it was a lot easier to "get there" and just felt generally impressive. But there is nothing I can explain about it qualitatively, it just supported or potentiated the effects, but most of all the meditative clarity and not so much the sensory distortion / hallucinatory component. I guess the former is what gets you into an ego dissolved state anyway.
It's not as simple as agonists causing downregulation and antagonists causing upregulation. Antagonists would typically be anti-depressants and anti-psychotics and there isn't really evidence to say that such antagonists help with upregulation or normalisation. Since we can't rely on such things our poor understanding is mainly what makes it hard to solve this problem.
Honestly I don't remember what kind of dose of LSD I took but 200 ug was not abnormal for me at the time.
Normally when one combines drugs it is not smart to take your usual dose of each, but to go lower. However I never considered nootropics as drugs and I did not expect a lowered dose to work out. I guess in my case it worked out because combining usual doses of each was fine, but I will not claim that this is recommended for everyone and it's entirely possible for someone to have a very extreme reaction. If you read Xorkoths report on piracetam with 2C-E you will probably understand what I mean:
http://www.erowid.org/experiences/exp.php?ID=48983
The only thing in general that I can say about the combo is that it was a lot easier to "get there" and just felt generally impressive. But there is nothing I can explain about it qualitatively, it just supported or potentiated the effects, but most of all the meditative clarity and not so much the sensory distortion / hallucinatory component. I guess the former is what gets you into an ego dissolved state anyway.
It's not as simple as agonists causing downregulation and antagonists causing upregulation. Antagonists would typically be anti-depressants and anti-psychotics and there isn't really evidence to say that such antagonists help with upregulation or normalisation. Since we can't rely on such things our poor understanding is mainly what makes it hard to solve this problem.