Since someone above asked how to induce ego loss...
I experienced ego loss yesterday. I first smoked a large doobie with a few friends, and waited for two more to show up. A couple hours passed, so I wasn't super roasted by the time they arrived, and we didn't wait long to get out the 5-MeO-DMT. They both gave it a shot, and then it was my turn. Before vaporizing my (9mg) dose I breathed deeply for a bit, and inhaled a large lungful of nitrous oxide. The nitrous came on strong and fast, bringing me up to the point of the 'noisy' colourful (but fairly mild) visuals I get when combining with pot. I vaporized and inhaled my dose and was wallopped first by the intense body buzz, then colour cycling 3D fractals, and finally dissolution of the ego.
I was completely unaware of my surroundings, self etc. I could also feel my ego dissolve, up to the point at which it was gone enough that I wasn't really around to notice anymore. Existence became pure sensation, and I have to say, it was pretty intense.
The above experience was the second time I tried 5-MeO-DMT so I had some idea what to expect. I have to say that 5-MeO-DMT has induced the quickest and purest ego loss I've experienced. Ego loss that I've gotten from mushrooms or acid was always accompanied by a lot of distorted thought, sometimes of a rather worrying nature, whereas 5-MeO-DMT left me about five seconds to worry before I ceased to exist.
Ego loss isn't my goal per se, but is usually a result of the intensity I seek. Yesterday it was quite pleasant, but I can definitely see how it can be a bit much, even terrifying. Other people have made many good suggestions/comments throughought the thread, so I won't repeat them, but instead suggest that if you think ego loss is something that you'll be experiencing again, you might want to try and, well, not get familiar with it, but maybe make its acquaintance under better terms.
Hm, that's more than I meant to write... well... Best of luck with your continued existence or lack thereof.