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The Big & Dandy bk-MDMA (Methylone) Thread

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but most people claim the exact opposite! :?

i don't think so. from what i've read and experienced methylone gives one a much clearer head than mdma. i do get pretty loved up and sometimes act just as if i was on mdma and have noticed a desire to talk that surpasses both mdma and amphetamine, but i'm much more in control of my actions than with mdma and get thoughts like "if i do xxx i'll look like a complete e-tard" (that doesn't mean that i won't necessarily do that thing what would make be look like a complete e-tard ;)) whereas on mdma i wouldn't even waste a thought about that.
 
Has anyone got any information on whether methylone reverses the SERT transporter protein like MDMA does? I have the impression that MDMA's neurotoxicity stems from this specific action. Correct me if I'm wrong :-)
 
Has anyone got any information on whether methylone reverses the SERT transporter protein like MDMA does? I have the impression that MDMA's neurotoxicity stems from this specific action. Correct me if I'm wrong :-)
it's not proven but highly likely that methylone does the same reversal of SERT (btw. the T in SERT stands for transporter already ;-))

the current hypothesis on mdma-induced neurotoxicity says that dopamine getting taken up into axon terminals (right word in english?) in absence of serotonin to get taken up and oxidised to a chemical that causes oxidadive stress. so the main components for this mechanism to work are DA release / reuptake inhibition and 5-HT depletion.

so methylone may cause enough serotonin depletion (i doubt it) and surely releases enough dopamine. even if it doesn't cause neurotoxicity like that mdma has shown in animal studies, it could exhibit neurotoxicity similar to methamphetamine and amphetamine as it releases \ "reuptake-inhibits" comparatively more dopamine and noradrenaline than mdma does, and therefore is more of a straight stimulant.
 
it's not proven but highly likely that methylone does the same reversal of SERT (btw. the T in SERT stands for transporter already ;-))

the current hypothesis on mdma-induced neurotoxicity says that dopamine getting taken up into axon terminals (right word in english?) in absence of serotonin to get taken up and oxidised to a chemical that causes oxidadive stress. so the main components for this mechanism to work are DA release / reuptake inhibition and 5-HT depletion.

so methylone may cause enough serotonin depletion (i doubt it) and surely releases enough dopamine. even if it doesn't cause neurotoxicity like that mdma has shown in animal studies, it could exhibit neurotoxicity similar to methamphetamine and amphetamine as it releases \ "reuptake-inhibits" comparatively more dopamine and noradrenaline than mdma does, and therefore is more of a straight stimulant.

Thanks for the thorough explanation! I have been using methylone quite alot, a bit too much probably, almost weekly in one whole year now, and haven't noticed any physical or mental side effects whatsoever, either in creativity, studies or socially, so my guess is that it's much more benign that MDMA. I'm taking melatonin, 5-htp (not consistantly, but pre/post-loading) and piracetam. I hope this has countered some of the potential neurotoxicity.
I'm still rarely moving past the 200 mg on one night, and the magic is still there, sometimes I even feel overwhelmed! Wonderful social enhancer, very talkative and friendly.
I have nothing bad to say about this drug.
 
^ I have also been (ab)using this chemical on and of for almost two years. Usually being on it almost every weekend for a period of a month or two, then taking brakes.
If I have been taking it a lot I can feel the loved up feeling diminish and getting a more pure stimulant feel, but after a month break it seems to work just as fine again.
I do use it a bit to much I think, but a positive effect is that I do not drink nearly as much when I use it compared to when I don't.

I always take vitamin C and magnesium before/during sessions and 5-htp for 2-3 days after.
A weekend of heavy drinking effects me a lot more, both physically and mentally, than a weekend on methylone.
 
it could exhibit neurotoxicity similar to methamphetamine and amphetamine as it releases \ "reuptake-inhibits" comparatively more dopamine and noradrenaline than mdma does, and therefore is more of a straight stimulant.

i think it is more of a good stimulant than anything else. I unintentionally lost 12 lbs over the course of 3 months using it.
 
i think it is more of a good stimulant than anything else. I unintentionally lost 12 lbs over the course of 3 months using it.

sounds nice. that's something like 5 kg and therfore exactly the amount of weight that i'd need to lose to get back to my ideal weight that i had previously unintentionally achieved after taking amphetamine every weekend for a year ;)=D
 
It is researched and said that a beer or too with MDMA dampens the nervous excitements (I think) and at least it prevents hyperthermia... would GHB with methylone do something similar?
I have my doubts about the research though since alcohol dehydrates you so I don't see how positive it can be...
 
Does methylone have less tolerance problems then MDMA?

From my experience, MDMC tolerance buildup is not as immediate or steep as MDMA. I have been using Methylone for 3 days (sleep in between each day) strait and have only increased my initial dose 100mg from the first day. Bumps were increased 25mg on the 3rd day.

I have a feeling the tolerance may creep and hit hard, which is one of the reasons why I'm going to take a break for a month or two.
 
That is also what I hear from others and experience myself naginnudej.
 
I have read alot of reports on M1, and it seems the consensus is that 250mg bombed is the way to go. When I was experimenting with this substance, I was using 100mg bomb, with another 100mg at about the 2 hour mark. The euphoria is lovely with my dose, but am I missing the real peak by not taking 200-250mgs?
 
naginnudej and Solipsis do you guys notice that you can only redose once? or dont you notice much tolerance from redosing either?
 
I find that the second redose is only effective if accompanied by marijuana. Otherwise, Erowid's dosage page says it all:

Some say that taking a booster dose more than 2 hours after the initial dose will not result in extending the desired effects.
 
Hmm I notice relatively less each subsequent redose but it's still pretty worthwhile.
It seems that you need to redose on the peak to extend that, if you are too late it doesn't do a lot of good.
I heard each redose you do is about 30% heavier on your body per same mg. Nonetheless bombing an attack dose is not something I think I'd prefer since it will be over pretty soon...
 
I've noticed that waiting about 6 hours from the last time you bombed your withering and pleading sanity with M1 is long enough to make the 2nd time qualitatively the same as the first.

But as everyone else agrees, something about the pathways it strikes makes it impossible to feel this particular brand of euphoria any longer than an hour or two.

I'm still of the opinion that this stuff emulates the same neuronal satiation routine one gets during/after a good piss. And that extending it over an hour is already pushing the system way over the length of time it's built to reward you for.

But that's partly because, for my part, while on Methylone I've found it almost impossible to squeeze out any offerings to the porcelain god unless you really *really* need to :p It's kind of like your brain keeps insisting to you "yeah, I know you think you need to pee right now, but as far as I'm concerned you're already getting the rewards from that task as we speak, so what's the problem?"
 
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I'm still of the opinion that this stuff emulates the same neuronal satiation routine one gets during/after a good piss. And that extending it over an hour is already pushing the system way over the length of time it's built to reward you for.

That's both interesting and hilarious. My wife and I were planning to try methylone for the first time on New Year's, but perhaps we'll just drink and piss a lot instead. ;)
 
When I took methylone yesterday I user Maalox with it (magnesium aluminium oxide). It basifies the stomache helping with absorption of these kinds of compounds. It worked! The comeup was noticeably faster and harder, there was no nausea whatsoever.

Only, enough magnesium can give you the shits... it's no bother though.
 
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