5-MeO-DMT is the most brutal and intense psychedelic I've ever tried and I doubt there's a more powerful compound (for me, subjectively of course) out there. I had smoked 5-MeO-DMT 50+ times and insufflated it some 20-30 times before smoking N,N-DMT. DMT actually felt benign in comparison. The brutal onslaught of 5-MeO-DMT is just so more powerful, the bodyload is more intense, the word "extreme" doesn't even give an adequate description of 5-MeO-DMT. I have a love-hate relationship with it. Sub-breakthrough experiences can be absolutely terrifying, I just get incapacitated, my heart is racing and I feel like I'm going to die. With breakthrough experiences it's very different because "I" is smashed into pieces in 15 seconds and I only feel absolute bliss, freedom, a strong feeling of profoundness. No other compound completely obliterates my ego, there's always a remnant of my ego left with other compounds. The afterglow is one of the best of all psychedelics, very euphoric, and lasts considerably longer than the afterglow of DMT. 5-MeO-DMT is more physical, the first time I smoked DMT I was surprised how benign it felt, yes it hit me hard and fast but not mercilessly.
I do like DMT more than 5-MeO-DMT, considerably more, but 5-MeO-DMT still has a special place in my heart. However nowadays I smoke it very rarely, and really have to consider if I want to take it. Big doses are my way of taking it, as I want to be sure there's a breakthrough.