Hey Kl519, I hope the break from tripping is going well.

Did you ever get to that combination of LSD, 4-HO-MiPT, and 2C-B that you wanted to before you stopped? I'm still jealous that you even have the option!
You know, I have to admit, despite saying before that I felt content having experienced 50 mg of 4-HO-MiPT without feeling the need to go back or push further, I honestly have not been able to stop thinking about it since then. I'm thinking that the strength of it might have just pushed me away at first because it was much greater than I was expecting for that dose... but now that some time has passed since then, I find myself becoming more and more curious about what I would get out of that level if I actually planned for it, or for going even deeper with it.
I would like to make one more observation on the variability of personal responses: I find it very interesting how many people say that it is just like mushrooms, because I think I would actually say that it may have been the least mushroom-like of any 4-substituted tryptamine I've tried so far. There are two very significant structure-activity patterns I have been noticing consistently throughout all of my experiences with these substances, the first being constrained to those with symmetrical but not asymmetrical nitrogen tail substitution patterns, and the second being constrained to those with at least one methyl group on their tail and one other straight but not forked alkyl group. So, in other words, the first group contains the 4-substituted DMTs, DETs, DiPTs, DPTs, and DALTs, whereas the second group contains the DMTs, METs, and MPTs. Notice how psilocin falls into each, but 4-HO-MiPT is not present in either?
The first collection of effects, present within the symmetrical tails, can be very easily identified by a very distinct and obvious visual effect, which appears much more readily with eyes closed or when in a dark room. This involves an extremely large number of arms often in hyperspatial garb reaching out towards me, sometimes attached to full human forms and other times simply acting on their own, and typically arranged into geometric designs such as winding spirals that tunnel back into the distance, projections outward from the center of my view in linear perspective, or in cascades raining down and slightly outward from atop my view. It has been exclusively shown in darker colors like blues, greens, or grays, but, on the other hand, is almost always accompanied by foreground imagery of turning faces that tend to use similar colors but in much lighter shades in the form of eye color, jewelry, or other such things. On the perceptual and behavioral fronts, these visuals have also associated very significantly with a consistent and recognizable effect of feeling like I am stuck in a dissociative whirlwind, with my mind just kind of dreamily flying around on its own, in such a way that seems to lead to immersive visions with the proper setting as well. I have experienced all of this relatively equally on a couple good grams of mushrooms, 25 mg of 4-HO-DET, 30 mg of 4-HO-DiPT, 60 mg of 4-HO-DPT, and 60 mg of 4-AcO-DALT, and I also found 50 mg of 4-AcO-DMT comparable to 100 mg of 4-HO-DPT in this way.
The second collection of effects also begins with a very notable visual effect, which also involves faces but in a different way than from before. Whereas the faces detailed above are very detailed and crisp, at the same time there is often a sort of flatness to them, a photorealistic but still ultimately cartoonish design. On the other hand, the faces I notice in this visual effect feel consistently three-dimensional and far more fully rendered, but notably still slightly sub-realistic, less so than a flat image, but more like maybe a virtual reality world. To follow this theme, it is also almost always accompanied by straight, white grid patterns appearing over surfaces, giving everything a particularly rendered feeling. However, rather than turning or moving in other ways like with the first group, these faces are more often static, occasionally shifting expression but not interacting much, and rather than being extremely vivid and close, they are often somewhat blurred and distant. Though, I should note that mushrooms, falling into both of these groups, do indeed give me a combination of both effects which I believe is probably why their entity perceptions are so much more complete for me than any of these other tryptamines still. Anyway, these visuals tend to be expressed through a wider variety of brighter but still deep colors, with red, green, blue, yellow, and white seeming to make the most common appearances. And finally, to contrast the first group, these visual effects seem to accompanied for me by, rather than an immersion in an inner world, a state of delusion brought about by bringing the mind into the outside world. I have experienced this about the same on a few grams of mushrooms, 50 mg of 4-AcO-DMT, 25 mg of 4-HO-MET, and 50 mg of 4-HO-MPT, and have gotten lesser versions on lower doses of each.
So, now I have to admit something else too.... While I say that these effects seem exclusive to these groups, I really believe that it is likely that each group is just more potent at its effect than the other, but that all of these tryptamines will probably do all of these things at a high enough dose. To that end, I have experienced a much weaker version of the reaching arms and turning faces effect on 50 mg each of 4-HO-MET and 4-HO-MPT, and I also had some of the virtual world and grid lines appearing during meditation on 100 mg of 4-HO-DPT, and I've seen a brief flash of it once on 4-HO-DET and 4-AcO-DET each. However, what makes me divide these groups into these categories is not the total exclusivity, but just the fact that these effects do consistently seem to appear much more often and much more potently at my lowest significantly psychedelic doses of their corresponding substances, and that they both appear together with psilocin. But then, as I pointed out before, I did not include 4-HO-MiPT in either list... because it does not do either of these things significantly for me at doses which produce fully active psychedelia. In fact, even at 50 mg I thought it really only maybe started hinting at either, and neither of them were significant at all compared to how intense the rest of the trip was. By that I mean the typical effects you would attribute to any strong psychedelic, the feeling of ego loss, thought, emotion, and sensory intensification, extreme visual tracers and distortions, and so on, but just not all of those more complex hallucinogenic effects that I tend to associate with other tryptamines. So, given that mushrooms have both of those qualities for me and all the other synthetic 4-substituted tryptamines I've tried had one of them, the one with neither is the one that seems the least like mushrooms to me.
Not to ramble on for
too long, but there's one last thought of mine to add in now which is where my personal appreciation for 4-HO-MiPT actually comes in strongly.... In regards to those basic psychedelic effects that 4-HO-MiPT has that you could expect from anything, I actually find it incredibly similar to LSD, I think second only to 4-HO-MPT of the 4-substituted tryptamines that I've tried. I have a theory about the general structure of the lysergamides in relation to these tryptamines... which I think is actually a pretty basic one, but I just never see it discussed. Technically, lysergamides can be viewed as conformationally constrained analogues of tryptamines, with LSD in particular being a locked version of MPT with the three hydrogen bonds on the last carbon of the propyl group replaced with a double-bonded oxygen and a nitrogen with two diethyl groups attached to it, whereas for instance LSA would simply be with a nitrogen attached. This would make it even closer to MPT itself, but a step further can actually be found in nature too, in the form of agroclavine, which not only is literally
just a constrained MPT with no further substitutions, but even sometimes occurs in higher amounts than LSA in some morning glory chemical composition analyses. See all of these chemicals, along with 4-HO-MPT, shown below:
So, first of all my thought would be that this clearly might be why 4-HO-MPT was the most LSD-like of the 4-substituted tryptamines for me, but I think it opens up other interesting avenues of speculation as well. For instance, 4-HO-MET is often described as feeling somewhat lysergic as well, and I feel this way about it too, but to me it feels much more like mushrooms but with a little lysergic flavoring, but not really entirely like LSD.... This could seemingly then be because the ethyl group is one carbon less than the propyl, so it's not as close to the LSD structure as 4-HO-MPT, but it is still one step closer than psilocin is. On the other hand, in one sense an isopropyl could even be seen as a step in the wrong direction because it adds a carbon group extended out somewhere where there isn't one on the lysergamide molecules, but however, an isopropyl is the most similar bulk extension to a propyl, it it not? I realized that logically it's probably not best to think about these structure-activity relationship as LSD-centric given that they work by mimicking serotonin, which should mean that it'd be much more logical to have something like psilocin as the starting point. So, from that perspective, I have to ask is it not possible that the "lysergic" feeling is one that is simply added to an N-methyltryptamine by extending the bulk of its other tail substitution, such that when it reaches three carbons a similar effect will be achieved whether it is through a propyl or an isopropyl?
Perhaps notably, MiPT is even more similar to LSD for me than 4-HO-MiPT is, which should make sense if you consider that LSD is a locked version of a tryptamine with no ring substitutions, thereby making a 4-hydroxy group a step away from its structure. On that note though, I think that step may also be very important for adding those effects to 4-HO-MPT that I also get from mushrooms and 4-HO-MET but which seem to be disrupted on 4-HO-MiPT. In reference to that I would also have to assert something about 4-HO-MPT: that even though I do indeed find it to be even more LSD-like than 4-HO-MiPT is, I also find it to be more mushroom-like to an even greater extent. The only explanation that I can come up with for it as that, at least in my brain, that isopropyl group must disrupt psilocin-like receptor binding relative to what the propyl group does much more so than it does the same for LSD-like receptor binding, the end result being a drug which is slightly less LSD-like in that particular style, but ultimately more LSD-like as a whole. Likewise, because neither 4-HO-MPT nor 4-HO-MiPT is
entirely like LSD even in the ways that they are similar, I feel that the lack of more overt mushroom-like effects also allows the subtle differences in its "like LSD but different"-ness to shine through more clearly, which is quite interesting in its own right.
Anyway, all of these thoughts are what have made me start to think that I will actually be attempting to explore more with 4-HO-MiPT in the future again.... Maybe I will find that at an even higher dose these one or both of these two distinct patterns of effect I've noticed in other tryptamines will show up together simply late for the party, and at that moment the distinction between 4-HO-MiPT and other 4-substituted tryptamines will be essentially obliterated? Maybe I'm just not sensitive enough to these effects to get them on doses of 4-HO-MiPT lower than 50 mg, whereas others get their own personal variants of them readily, or, possibly, just get something entirely different.... I'm not complaining though, as this atypical predominantly LSD-likeness is really what has caused my interest in this and other MiPT molecules to suddenly peak, and I wouldn't want to rob them of the thing I find the most unique about them. Quite frankly, I am intending to try 5-MeO-MiPT within the next day or two and am secretly hoping that it will have this special "lysergic" feeling for me as well.
Alrighty, I will shut up now....