any major dude
Bluelight Crew
generally speaking, 4-substituted tryptamines are very safe when used responsibly. However, no serious academic study has been done on this chemical, so if there are any long term effects we don't know. But given that psilocin is all but non-toxic & 4-HO-MET is psilocin with one of its methyl groups extended into an ethyl, it should be reasonably safe.